Metastatic Malignant Melanoma of the Inguinal Lymph Node with Unknown Primary Lesion

Background. Malignant melanoma could present with metastasis with unknown primary (MUP) and this happens in 2-3% according to the studies. Around 90% of melanomas have cutaneous origin, but still there are melanomas that could be found in visceral organs or lymph nodes with unknown primary site. Spontaneous regression of the primary site could be an explanation.Case Report. We report a 58-year-old Caucasian male who presented with a right sided swelling in the inguinal region. Surgery was performed and biopsy showed metastatic malignant melanoma. No cutaneous lesions were identified by history or physical examination. Work up could not detect the primary lesion and patient was started on radiotherapy and immunotherapy.Conclusion. We present a case of malignant melanoma of unknown primary presenting in an unusual place which is the inguinal lymph node. Theories try to explain the pathway of development of such tumors and one of the theories mentions that it could be a spontaneous regression of the primary cutaneous lesion. Another theory is that it could be from transformation of aberrant melanocyte within the lymph node. Prognosis is postulated to be better in this case than in melanoma with a known primary.

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Metastatic Malignant Melanoma of the Inguinal Lymph Node with Unknown Primary Lesion: A Case Report

International Journal of Contemporary Pathology ◽

10.5958/2395-1184.2017.00013.4 ◽

2017 ◽

Vol 3 (2) ◽

pp. 13

Author(s):

Guddi Rani Singh ◽

Jiut Ram Keshari ◽

Bhim Ram ◽

Vijayanand choudhary ◽

Ravi Bhushan Raman

Keyword(s):

Case Report ◽

Lymph Node ◽

Malignant Melanoma ◽

Inguinal Lymph Node ◽

Metastatic Malignant Melanoma ◽

Primary Lesion ◽

Unknown Primary

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Isolated Metastatic Malignant Melanoma of the Right Inguinal Lymph Node with Unknown Primary Lesion

Journal of Enam Medical College ◽

10.3329/jemc.v8i3.38370 ◽

2018 ◽

Vol 8 (3) ◽

pp. 174-176

Author(s):

Debasish Das ◽

Deb Prosad Paul ◽

Kazi Sohel Iqbal

Keyword(s):

Lymph Node ◽

Malignant Melanoma ◽

Inguinal Lymph Node ◽

Uv Light ◽

Light Exposure ◽

Metastatic Malignant Melanoma ◽

Lymph Node Biopsy ◽

Primary Lesion ◽

Unknown Primary ◽

Complete Excision

Malignant melanoma develops from the pigment containing cells known as melanocytes. Melanoma is more common in men than in women. It is found typically in the skin. It is also found in the mouth, intestine, eye and other sites. Melanoma may develop from a mole with changes including an increasing in size, irregular edges, changes in color, itchiness or skin breakdown. Prognosis is poor if it is not treated early. The primary cause of melanoma is UV light exposure. Patients with history of affected family members and poor immune function are at greater risk. Diagnosis is by biopsy from any affected skin lesion. Recurrence is common even many years after the initial diagnosis. Here we present a case of malignant melanoma of the inguinal lymph node with unknown primary lesion. Surgery was done with complete excision of inguinal lymph node. Biopsy report showed metastatic malignant melanoma.J Enam Med Col 2018; 8(3): 174-176

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Challenges in the differential diagnosis of interdigitating dendritic cell sarcoma of intraparotid lymph node vs. metastatic malignant melanoma with unknown primary site

International Journal of Surgical Pathology ◽

10.1177/1066896914567333 ◽

2015 ◽

Vol 23 (3) ◽

pp. 248-252 ◽

Cited By ~ 6

Author(s):

Fernando Galli ◽

Viktorija Petraitiene ◽

Senthil Kumar Muthu ◽

Sophie James ◽

Venkata Rao Koppana ◽

...

Keyword(s):

Differential Diagnosis ◽

Lymph Node ◽

Malignant Melanoma ◽

Metastatic Malignant Melanoma ◽

Primary Site ◽

Unknown Primary ◽

Unknown Primary Site ◽

Cell Sarcoma ◽

Dendritic Cell Sarcoma ◽

Interdigitating Dendritic Cell Sarcoma

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Inguinal Lymph Node Squamous Cell Carcinoma of Unknown Primary Site

Cirugía Andaluza ◽

10.37351/2021323.14 ◽

2021 ◽

Vol 32 (3) ◽

pp. 411-414

Author(s):

L Pina ◽

D Sinagra ◽

ME Paradedao ◽

MA Juárez ◽

F Muñoz Pozo

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Cell Carcinoma ◽

Squamous Cell ◽

Inguinal Lymph Node ◽

Primary Site ◽

Unknown Primary ◽

Unknown Primary Site ◽

Carcinoma Of Unknown Primary

Resumen El carcinoma escamoso de piel y mucosas presenta un riesgo potencial de metástasis ganglionares, con la posibilidad de que este suceso preceda la presentación clínica del tumor primario. El objetivo del presente trabajo es describir un caso de linfadenectomía inguinal por metástasis de carcinoma escamoso de origen primario desconocido y realizar una revisión bibliográfica de los casos presentados en la literatura médica. Se describió el caso de un hombre de 84 años con una tumoración inguinal correspondiente a una neoplasia escamosa, se le realizó una evaluación multidisciplinaria con dermatología, urología y coloproctología, sin encontrar el tumor primario. Se efectuó un vaciamiento inguinal con radioterapia postoperatoria. En la base de datos de Medline informaron solo 49 casos en los últimos 10 años. Las metástasis inguinales de carcinomas escamosos representan un grupo heterogéneo de neoplasias que pueden originarse a partir de la región anogenital o de territorios cutáneos de la zona perineal, miembros inferiores o parte baja del tronco. El manejo diagnóstico y terapéutico de estas lesiones continúa siendo un desafío al que se debe enfrentar con todas las herramientas disponibles y de forma multidisciplinaria.

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