FC35 the effect of buffer species on the drug release from beads coated with the cationic acrylic polymer dispersions;, Eudragit RS 30D or RL 30D

1994 ◽  
Vol 2 (1-2) ◽  
pp. 109 ◽  
Author(s):  
R. Bodmeier ◽  
X. Guo
Keyword(s):  
Drug Release ◽  
Acrylic Polymer ◽  
Eudragit Rs ◽  
Eudragit Rs 30D ◽  
Polymer Dispersions

scholarly journals In vitro Release Kinetics Study of Ambroxol Hydrochloride Pellets Developed by Extrusion Spheronization Technique Followed by Acrylic Polymer Coating

1970 ◽  
Vol 7 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Ishtiaq Ahmed ◽  
Monzurul Amin Roni ◽  
Golam Kibria ◽  
Muhammad Rashedul Islam ◽  
Reza-ul Jalil
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
In Vitro Dissolution ◽  
Acrylic Polymer ◽  
Eudragit Rs ◽  
Methacrylate Copolymer ◽  
Ambroxol Hydrochloride ◽  
Eudragit Rl ◽  
Extrusion Spheronization

The aim of the present study was to investigate the effect of Ammonio Methacrylate Copolymer Dispersion Type A (Eudragit RL 30 D) and Ammonio Methacrylate Copolymer Dispersion Type B (Eudragit RS 30 D) combination in different weight ratios on the release kinetics of Ambroxol Hydrochloride from coated pellets. Microcrystalline cellulose, lactose, maize starch, hydroxypropyl methylcellulose and the drug was incorporated in the nuclei prepared by Extrusion-Spheronization technique which was coated with Eudragit RL 30D and Eudragit RS 30D in 1:1,1:1.5,1:2,1:2.5 and 1:3 ratios. The in vitro dissolution studies were carried out in 0.1N HCl for 1 hour followed by phosphate buffer (pH 6.8) for 11 h with USP dissolution apparatus Type-II. Drug release decreased with increasing amount of Eudragit RS 30 D in all cases. The drug release followed first order and Higuchi release kinetics. The Korsmeyer plot revealed n=0.50-0.61 or non-Fickian transport mechanism for drug release. From one way ANOVA it was found that the ratio of binary polymer mixer had significant (p < 0.05) effect on drug release. Key words: Aqueous coating, Eudragit, release kinetics, pellet, extrusion-spheronization  DOI = 10.3329/dujps.v7i1.1222 Dhaka Univ. J. Pharm. Sci. 7(1): 75-81, 2008 (June)

Formulation and Evaluation of Luliconazole Microsponges Loaded Gel for Topical Delivery

2021 ◽  
pp. 5775-5780
Author(s):  
Farhana Sultan ◽  
Himansu Chopra ◽  
Gyanendra Kumar Sharma
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Ethyl Cellulose ◽  
Entrapment Efficiency ◽  
Topical Delivery ◽  
Production Yield ◽  
In Vitro Drug Release ◽  
Eudragit Rs ◽  
Diffusion Studies

Microsponge containing Luliconazole (LCZ) with different proportion of drug:polymer (Ethyl cellulose and Eudragit RS 100) were obtained efficiently using Quasi-emulsion solvent diffusion method. Luliconazole is an anti-fungal drug used for the topical delivery. The purpose of the microsponge formulation is to control the release of LCZ drug to the skin through Microsponge Delivery System (MDS) known to be the novel technique which overcome the maximum concentration of active ingredient, frequency doses, and skin irritation. The prepared microsponges were examined using drug content, % production yield, % entrapment efficiency and in-vitro drug release. The formulation were subjected to in-vitro drug release studies for 6 hr in which it was concluded that Ethyl cellulose microsponges formulated by drug:polymer (1:1) and Eudragit RS 100 microsponges formulated by drug:polymer (1:3) showed maximum controlled release i.e., Increase in drug:polymer ratio (1:1 to 1:9) increased the production yield and entrapment efficiency of microsponges using Ethyl cellulose with no significant effect for Eudragit RS 100.Therefore, both formulation F1 and F2 was dispersed in carbopol gel preparation for controlled delivery of LCZ to the skin. Various physical parameters like pH, spreadability, viscosity and in-vitro drug diffusion studies were evaluated for the prepared gel formulations. Microsponge gel formulation i.e., FG1 showed better results for controlled release of 89.40% as compared to FG2 i.e., 92.18% over the period of 12 hrs which is performed in Franz Diffusion Cell. On basis of in-vitro diffusion studies for LCZ gel formulation, microsponges using Ethyl cellulose (FG1) was found to be best for its controlled release of LCZ for 12 hrs and followed zero order kinetics. Hence, formulated LCZ loaded gel have potential to treat fungal infections i.e., tinea pedis, tinea cruris and tinea corporis.

scholarly journals Ecotoxicological assessment of nanoparticle-containing acrylic copolymer dispersions in fairy shrimp and zebrafish embryos

2017 ◽  
Vol 4 (10) ◽  
pp. 1981-1997 ◽  
Author(s):  
Tamara S. Galloway ◽  
Yuktee Dogra ◽  
Natalie Garrett ◽  
Darren Rowe ◽  
Charles R. Tyler ◽  
...  
Keyword(s):  
Aquatic Toxicity ◽  
Zebrafish Embryos ◽  
Fairy Shrimp ◽  
Acrylic Copolymer ◽  
Acrylic Polymer ◽  
Ecotoxicological Assessment ◽  
Acute Aquatic Toxicity ◽  
Polymer Dispersions

Nanoparticle-containing acrylic polymer dispersions showed virtually no acute aquatic toxicity in fairy shrimp and zebrafish embryos.

Eudragit RS 100 microparticles containing 2-hydroxypropyl-β-cyclodextrin and glutathione: Physicochemical characterization, drug release and transport studies

2007 ◽  
Vol 30 (1) ◽  
pp. 64-74 ◽  
Author(s):  
Adriana Trapani ◽  
Valentino Laquintana ◽  
Nunzio Denora ◽  
Angela Lopedota ◽  
Annalisa Cutrignelli ◽  
...  
Keyword(s):  
Drug Release ◽  
Physicochemical Characterization ◽  
Eudragit Rs ◽  
Transport Studies

scholarly journals MULTIPARTICULATE FLOATING DRUG DELIVERY SYSTEM OF ANAGLIPTIN: DESIGN AND OPTIMIZATION FOR ITS EFFICACY IN MANAGEMENT OF METABOLIC SYNDROME

2019 ◽  
pp. 171-181
Author(s):  
RAKESH V. MISHRA ◽  
SHASHIKANT N. DHOLE
Keyword(s):  
Metabolic Syndrome ◽  
Drug Release ◽  
Wistar Rats ◽  
Lag Time ◽  
Cafeteria Diet ◽  
High Density Lipoproteins ◽  
Eudragit Rs ◽  
The Metabolic Syndrome ◽  
Male Wistar Rats ◽  
Eudragit Rl

Objective: The present research aims to design and optimize gastroretentive floating pellets of anagliptin (a dipeptidyl peptidase-4 inhibitor), so as to reduce P-Glycoprotein (PGP)–mediated efflux in the intestine hence to improve oral bioavailability. Methods: The drug-containing core pellets were prepared by extrusion and spheronization process followed by subsequent coating with three successive layers i.e. Eudragit RS 100, sodium bicarbonate (NaHCO3): hydroxypropyl methylcellulose E5LV (HPMC E5LV) and Eudragit RL 100 using fluidized bed processor. A 3 level 3 factor box-behnken design was adopted to investigate the effect of Eudragit RS 100, NaHCO3: HPMC E5LVand Eudragit RL 100 on floating lag time and drug release at 10 h. Desirability function under numerical optimization technique was used to identify the optimum formulation. Results: The study reveals the significant effect of the amount of NaHCO3 and coating level of polymers on floating lag time and drug release. The optimum system could float within 4 min and exhibited more than 85% drug release in 10 h. The pharmacokinetic study conducted in male Wistar rats indicated 2.51 fold increase in relative bioavailability of optimized formulation compare to anagliptin drug. Formulated anagliptin pellets were evaluated in cafeteria diet-induced metabolic syndrome model in male Wistar rats. Anagliptin floating pellets treatment compared to cafeteria diet group significantly inhibited increase in body weight (238.79±2.52 g vs. 277.98±3.69 g, P<0.001), calorie intake (2283.99 kcal vs. 3086.05 kcal, P<0.05) and serum levels of total cholesterol (95.19±0.61 mg/dl vs. 110.04±1.31 mg/dl, P<0.01), triglycerides (96.12±1.25 mg/dl vs. 105.99±1.29 mg/dl, P<0.01) while high-density lipoproteins levels were improved (42.15±0.92 mg/dl vs. 30.92±0.77 mg/dl, P<0.01) indicated its hypophagic and anti-hyperlipidemic effects. Conclusion: The gastroretentive floating pellets of anagliptin was obtained and could be a promising technique to deliver anagliptin with improved bioavailability in the management of the metabolic syndrome.

scholarly journals Development and in vitro evaluation of chitosan-Eudragit RS 30D composite wound dressings

2006 ◽  
Vol 7 (1) ◽  
pp. E215-E220 ◽  
Author(s):  
Sakchai Wittaya-areekul ◽  
Chureerat Prahsarn ◽  
Srisagul Sungthongjeen
Keyword(s):  
Wound Dressings ◽  
In Vitro Evaluation ◽  
Eudragit Rs ◽  
Eudragit Rs 30D

scholarly journals The Effect of Thermal-Treating on Drug Release from Sustained Release Alginate-Eudragit RS Matrices

2020 ◽  
Author(s):  
Ehsan Kaffash ◽  
Mohammadreza Abbaspour ◽  
Hadi Afrasiabi Garekani ◽  
Zohreh Jahanian ◽  
Farinaz Saremnejad ◽  
...  
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Eudragit Rs

scholarly journals Liqui-Mass Technology as a Novel Tool to Produce Sustained Release Liqui-Tablet Made from Liqui-Pellets

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1049
Author(s):  
Matthew Lam ◽  
Nour Nashed ◽  
Ali Nokhodchi
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Tween 80 ◽  
Tween 20 ◽  
Release Formulation ◽  
Sustained Release Formulation ◽  
Eudragit Rs ◽  
Release Analysis ◽  
Insoluble Drugs ◽  
Eudragit Rs Po

The Liqui-Mass technology (also known as Liqui-Pellet technology) has shown promising results in terms of enhancing the drug release rate of water insoluble drugs in a simplistic approach. However, there is no current study on sustained-release formulation using the Liqui-Mass technology. In this study, an attempt was made to produce a sustained-release Liqui-Tablet for the first time using a matrix-based approach. The non-volatile co-solvent used in the investigation included Tween 80, Tween 20 and Kolliphor EL. The production of sustained-release propranolol hydrochloride Liqui-Tablet was successful, and data from the saturation solubility test and dissolution test did not show much difference among the mentioned non-volatile co-solvent. The best Liqui-Tablet formulation took 24 h for drug release to reach at around 100%. There seemed to be a synergistic retarding drug release effect when a non-volatile co-solvent and Eudragit RS PO were used together. The increase of Eudragit RS PO concentration increased the retardant effect. Kinetic drug release analysis suggests that the best formulation followed the Higuchi model. The flowability of pre-compressed Liqui-Tablet pellets had no issues and its size distribution was narrow. Liqui-Tablet was generally robust and most formulations passed the friability test. The study revealed that Liqui-Mass technology can be employed to sustain drug release.

Sign in / Sign up

Export Citation Format

Share Document