The specificity of p53 mutation spectra in sunlight induced human cancers

1995 ◽  
Vol 28 (2) ◽  
pp. 115-124 ◽  
Author(s):  
Leela Daya-Grosjean ◽  
Nicolas Dumaz ◽  
Alain Sarasin
Keyword(s):  
P53 Mutation ◽  
Human Cancers ◽  
Mutation Spectra

scholarly journals p53 mutations as fingerprints of environmental carcinogens

2000 ◽  
Vol 72 (6) ◽  
pp. 995-999 ◽  
Author(s):  
Rengul Cetin-Atalay ◽  
Mehmet Ozturk
Keyword(s):  
Great Majority ◽  
P53 Gene ◽  
Suppressor Gene ◽  
Protein Product ◽  
P53 Mutation ◽  
P53 Mutations ◽  
Environmental Carcinogens ◽  
Molecular Fingerprints ◽  
Human Cancers ◽  
Mutation Spectra

Mutations of the p53 tumor suppressor gene occur in a great majority of human cancers. The protein product of p53 gene is involved in DNA damage response. Consequently, p53 gene may be a preferred target for environmental carcinogens, which also act as DNA-damaging agents. This is probably why p53 mutations are frequent in cancers linked to environmental carcinogens. Moreover, these carcinogens leave molecular fingerprints on the p53 gene. Thus, the study of p53 mutation spectra has been a useful approach to implicate suspected carcinogens to different human cancers. This review provides further insight into the significance of p53 mutation spectra in ten common human malignancies (skin, liver, lung, bladder, breast, head and neck, esophagus, stomach and colorectal cancers, and hematological malignancies), in relation with environmental carcinogens.

scholarly journals Etiologic value of p53 mutation spectra and differences with histology in lung cancers

2008 ◽  
Vol 99 (2) ◽  
pp. 287-295 ◽  
Author(s):  
Takuo Shimmyo ◽  
Akira Okada ◽  
Takehisa Hashimoto ◽  
Yasuhito Kobayashi ◽  
Youhei Miyagi ◽  
...  
Keyword(s):  
P53 Mutation ◽  
Lung Cancers ◽  
Mutation Spectra

p53 mutation spectra for squamous cell carcinomas at different levels of human bronchial branches

2006 ◽  
Vol 119 (3) ◽  
pp. 501-507 ◽  
Author(s):  
Takuo Shimmyo ◽  
Takehisa Hashimoto ◽  
Yasuhito Kobayashi ◽  
Youhei Miyagi ◽  
Yuichi Ishikawa ◽  
...  
Keyword(s):  
Squamous Cell ◽  
P53 Mutation ◽  
Squamous Cell Carcinomas ◽  
Mutation Spectra ◽  
Different Levels

THE ROLE OF TGFΒ IN HUMAN CANCERS

Pathology ◽  
2001 ◽  
Vol 33 (1) ◽  
pp. 85-92 ◽  
Author(s):  
Shew-Fung Wong, Leslie C. Lai
Keyword(s):  
Human Cancers

Specific inhbitor of ERK 1/2 AEZS-131: anticancer activity in models of human cancers with and without overactivation of ERK 1/2

2014 ◽  
Vol 74 (S 01) ◽  
Author(s):  
JB Engel ◽  
S Meyer ◽  
J Dietl ◽  
B Kwok ◽  
O Ortmann ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Human Cancers

THE ROLE OF THE GENETIC ABNORMALITIES, EPIGENETIC AND microRNA IN THE PROGNOSIS OF CHRONIC LYMPHOCYTIC LEUKEMIA

2018 ◽  
Vol 40 (4) ◽  
pp. 261-267 ◽  
Author(s):  
K Tari ◽  
Z Shamsi ◽  
H Reza Ghafari ◽  
A Atashi ◽  
M Shahjahani ◽  
...  
Keyword(s):  
B Cells ◽  
Chronic Lymphocytic Leukemia ◽  
Kinase Inhibitors ◽  
Bone Marrow Involvement ◽  
P53 Mutation ◽  
Lymphocytic Leukemia ◽  
Gene Promoters ◽  
Epigenetic Changes ◽  
Genetic Changes ◽  
Trisomy 12

Chronic lymphocytic leukemia (CLL) is increased proliferation of B-cells with peripheral blood and bone marrow involvement, which is usually observed in older people. Genetic mutations, epigenetic changes and miRs play a role in CLL pathogenesis. Del 11q, del l17q, del 6q, trisomy 12, p53 and IgVH mutations are the most important genetic changes in CLL. Deletion of miR-15a and miR-16a can increase bcl2 gene expression, miR-29 and miR-181 deletions decrease the expression of TCL1, and miR-146a deletion prevents tumor metastasis. Epigenetic changes such as hypo- and hypermethylation, ubiquitination, hypo- and hyperacetylation of gene promoters involved in CLL pathogenesis can also play a role in CLL. Expression of CD38 and ZAP70, presence or absence of mutation in IgVH and P53 mutation are among the factors involved in CLL prognosis. Use of monoclonal antibodies against surface markers of B-cells like anti-CD20 as well as tyrosine kinase inhibitors are the most important therapeutic approaches for CLL.

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