C-peptide and the classification of diabetes mellitus patients in the Early treatment diabetic retinopathy study report number 6

Currently no unified generally accepted classification of intraocular changes due to diabetes mellitus (DM), in particular, diabetic retinopathy (DR). The methodological heterogeneity of the existing classifications is largely due to the different directions of their application. Some classifications are optimal for the choice of surgical treatment tactics, others - for laser and / or combined interventions. Obviously, the valuation of any classification lies in the completeness whole palette of available clinical and morphological changes considering staging pathogenetic process. Therefore, the search for optimal classification of DR that meets current possibilities of treating vitreoretinal pathology is the subject of a lively discussion. Key words: classifications, diabetic retinopathy, advantages and limitations.

Download Full-text

Impaired color vision associated with diabetic retinopathy: Early Treatment Diabetic Retinopathy Study Report No. 1511A list of the Early Treatment Diabetic Retinopathy Study investigators appears at the end of Early Treatment Diabetic Retinopathy Study Report No. 7 (Ophthalmology 1991;98:741–756).

American Journal of Ophthalmology ◽

10.1016/s0002-9394(99)00227-5 ◽

1999 ◽

Vol 128 (5) ◽

pp. 612-617 ◽

Cited By ~ 41

Author(s):

Donald S Fong ◽

Franca B Barton ◽

George H Bresnick

Keyword(s):

Diabetic Retinopathy ◽

Color Vision ◽

Early Treatment ◽

Study Report

Download Full-text

Classification of Farnsworth-Munsell 100-hue test results in the early treatment diabetic retinopathy study

American Journal of Ophthalmology ◽

10.1016/j.ajo.2004.02.009 ◽

2004 ◽

Vol 138 (1) ◽

pp. 119-124 ◽

Cited By ~ 14

Author(s):

Franca B. Barton ◽

Donald S. Fong ◽

Genell L. Knatterud

Keyword(s):

Diabetic Retinopathy ◽

Early Treatment ◽

Test Results

Download Full-text

Deep Learning based Method for Multi-class Classification of Diabetic Retinopathy

Journal of Informatics Electrical and Electronics Engineering (JIEEE) ◽

10.54060/jieee/002.02.016 ◽

2021 ◽

Vol 2 (2) ◽

pp. 1-5

Author(s):

Komal Damodara ◽

Keyword(s):

Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Deep Learning ◽

Blood Sugar Level ◽

Retinal Disease ◽

Fundus Imaging ◽

Retinal Blood Vessels ◽

The World ◽

Multi Class Classification

Diabetes mellitus is a form of diabetes with secondary microvascular complication leading to renal dysfunction and retinal loss also termed as diabetic retinopathy. Retinopathy is grave form of retinal disease. It is the leading cause of blindness in the world. Blockage of tiny minute retinal blood vessels due to the high blood sugar level is the reason why retinopathy leads to blindness or loss of vision. This study serves the purpose of deep learning-based diagnosis of Diabetic retinopathy using the fundus imaging of the eye. In this study architectures such as VGG 16 and VGG 19 are deployed in order to classify the images into 5 categories. The performance of the two models were compared. The highest accuracy is 77.67% when using the VGG 16 pre-trained model.

Download Full-text

Ο ρόλος των αντινεοαγγειακών παραγόντων στο διαβητικό οίδημα της ωχράς

10.12681/eadd/35828 ◽

2015 ◽

Author(s):

Ευαγγελία Παπαβασιλείου

Keyword(s):

Diabetic Retinopathy ◽

Macular Edema ◽

Diabetic Macular Edema ◽

Research Group ◽

Early Treatment ◽

Laser Photocoagulation ◽

Study Research ◽

Study Report

Η πιο συναρπαστική αλλαγή στη θεραπεία της διαβητικής αμφιβληστροειδοπάθειας ήταν με την έλευση της αντι-VEGF θεραπείας με ranibizumab (Lucentis, Genentech) για το διαβητικό οίδημα της ωχράς κηλίδας (DME) (Brown et al, 2013). Το πιο σημαντικό αποτέλεσμα που έδειξαν οι μελέτες RISE και RIDE είναι ότι οι ασθενείς με ΔOΩ που αφορά το κεντρικό βοθρίο έχουν μια πολύ καλή ευκαιρία να αυξήσουν σημαντικά την όρασή τους σε σχέση με ό,τι ήταν δυνατό να επιτύχουν με τη φωτοπηξία με λέιζερ. (Brown et al, 2013) O παράγοντας αντι-VEGF είναι η θεραπεία πρώτης γραμμής για το ΔOΩ με κεντρική συμμετοχή για πολλούς κλινικούς γιατρούς. Ωστόσο, για τους ασθενείς που παρουσιάζουν εντοπισμένο οίδημα που πληροί τα κριτήρια ETDRS, οι κλινικοί γιατροί θα πρέπει να χρησιμοποιούν το εστιακό laser (Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study report number 1, Early Treatment Diabetic Retinopathy Study research group). Tα στοιχεία της οπτικής οξύτητας κατά τη μελέτη ETDRS έδειξαν ότι περίπου το 15% των ασθενών υπό θεραπεία με λέιζερ βελτιώθηκε κατά 3 γραμμές, ενώ στις μελέτες RIDE και RISE, περίπου σε 40% των ασθενών η οπτική οξύτητα βελτιώθηκε κατά 3 γραμμές με την αντι-VEGF θεραπεία. Στη μελέτη μας μπορέσαμε να δείξουμε ότι η συνδυαστική θεραπεία με λέιζερ και αντινεοαγγειακούς παράγοντες ήταν ανώτερη της μονοθεραπείας με λέιζερ. Ακόμα δείξαμε ότι η συνδυαστική θεραπεία ελάττωσε την ανάγκη για ένεσεις κατά τη διάρκεια του δεύτερου έτους θεραπείας και την ανάγκη για λέιζερ, με καλύτερα αποτελέσματα ως προς τη βέλτιστα διορθούμενη οπτική οξύτητα και το πάχος στην οπτική τομογραφία συνοχής. Προτείνουμε τηνέναρξη με τρεις μηνιαίες ενέσεις και λέιζερ κατά τον τρίτο μήνα. Στη συνέχεια προτείνουμε το συνδυασμό λέιζερ και αντι-VEGF όταν χρειάζεται. Βρήκαμε ότι υπάρχει ακόμα ένας ρόλος για το θερμικό λέιζερ στο ΔOΩ. Για το ΔOΩ που δεν αφορά το βοθρίο, και τα κυκλοτερή σκληρά εξιδρώματα η λέιζερ θεραπεία θεωρείται ακόμα η θεραπεία πρώτης γραμμής.

Download Full-text

Assessing the Severity of Diabetic Retinopathy: Early Treatment Diabetic Retinopathy Study Report Number 10

Ophthalmology ◽

10.1016/j.ophtha.2019.11.028 ◽

2020 ◽

Vol 127 (4) ◽

pp. S97-S98

Author(s):

Srinivas R. Sadda

Keyword(s):

Diabetic Retinopathy ◽

Early Treatment ◽

Study Report

Download Full-text

Prevalence and characteristics of primary open-angle glaucoma in patients with diabetic retinopathy in type 2 diabetes mellitus

Archive of Ukrainian Ophthalmology ◽

10.22141/2309-8147.9.1.2021.229519 ◽

2021 ◽

Vol 9 (1) ◽

pp. 14-20

Author(s):

S.Yu. Mogilevskyy ◽

K.A. Hudzenko

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Stage I ◽

Open Angle

Background. Numerous literature data made it possible to establish the dependence of primary open-angle glaucoma (POAG) in patients with diabetic retinopathy (DR) on type 2 diabetes mellitus (DM2). The purpose was to determine the prevalence and characteristics of primary open-angle glaucoma in patients with diabetic retinopathy in type 2 diabetes mellitus. Material and methods. One thousand four hundred and fifty patients with DM2 were examined, in whom the stage of DR was determined according to the classification of American Academy of Ophthalmology (2002). POAG stage was established according to the classification of A.P. Nesterov and A.Ya. Bunin (1976) and classification of perimetric changes by glaucoma stages. The age of patients, 970 (66.9 %) men and 480 (33.1 %) women, was from 45 to 75 years. The duration of DM2 was from 2 to 15 years. For statistical studies, MedStat and MedCalc v.15.1 (Medcalc Software bvba) were used. Results. In patients with DM2 and DR of different stages, the prevalence of POAG amounted to 20.8 %, which is 4–6 times higher than in the general population. Among individuals with DR stage I (no retinopathy), 71.6 % had POAG stage I and II, among patients with non-proliferative DR, 87.6 % had stages II and III, and among those with proliferative DR, 78.4 % had stages III and IV. Among all patients with DR and POAG, the proportion of normal tension glaucoma was 18.6 %, which did not differ from that in POAG without DM2. 42.9 % of patients initially had the development of DM2 in past medical history, joined by POAG in 1–7 years, and 57.1 % first had POAG, joined by DM2 in 1–8 years. Depending on the duration of the disease, the severity of both DR and POAG increased, which indicated the dependence of DR and POAG severity on disease duration and acceleration of their development if they combined. Conclusions. The results of the study confirmed the wider prevalence and mutual burden of DR course in DM2 and POAG, which justifies the need to study the general mechanisms of their pathogenesis.

Download Full-text