LONG TERM EFFECTS OF PERINATAL EXPOSURE TO X-RADIATION OR DRUGS: A MORPHOLOGICAL, BIOCHEMICAL AND FUNCTIONAL STUDY IN RAT

Fipronil is an insecticide widely used in agriculture, veterinary medicine and public health that has recently been listed as a potential endocrine disrupter. In the present study we evaluated the effects of perinatal exposure to fipronil during the period of sexual brain differentiation and its later repercussions on reproductive parameters in male rats. Pregnant rats were exposed (via gavage) to fipronil (0.03, 0.3 or 3 mg kg–1) from Gestational Day 15 until Postnatal Day 7. Fipronil exposure did not compromise the onset of puberty. In adulthood, there was no effect on organ weight or sperm production. Furthermore, there were no adverse effects on the number of Sertoli cells per seminiferous tubule, testicular and epididymal histomorphometry or histopathology or expression patterns of androgen receptor in the testis. Similarly, no changes were observed in the sexual behaviour or hormone levels. However, in rats exposed to fipronil, changes in sperm motility were observed, with a decrease in motile spermatozoa and an increase in non-mobile spermatozoa, which can compromise sperm quality in these rats. Perinatal exposure to fipronil has long-term effects on sperm parameters, and the epididymis can be a target organ. Additional studies should be undertaken to identify the mechanisms by which fipronil affects sperm motility.

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Perinatal exposure to parasiticide ivermectin: long-term effects on reproductive parameters of adult male rats

Toxicological and Environmental Chemistry ◽

10.1080/02772248.2010.523930 ◽

2011 ◽

Vol 93 (2) ◽

pp. 345-351

Author(s):

Eduardo Wladimir Avilés Terneux ◽

Davi Abeid Pontes ◽

Carla Dal Bianco Fernandez ◽

Arielle Cristina Arena ◽

Elaine Manoela Porto ◽

...

Keyword(s):

Adult Male ◽

Male Rats ◽

Perinatal Exposure ◽

Reproductive Parameters ◽

Long Term Effects

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The Short- and Long-Term Effects of Seprafilm®on Peripheral Nerves: A Histological and Functional Study

Journal of Reconstructive Microsurgery ◽

10.1055/s-0029-1215526 ◽

2009 ◽

Vol 25 (06) ◽

pp. 345-354 ◽

Cited By ~ 14

Author(s):

Christina Magill ◽

Sami Tuffaha ◽

Andrew Yee ◽

Janina Luciano ◽

Daniel Hunter ◽

...

Keyword(s):

Peripheral Nerves ◽

Functional Study ◽

Long Term Effects ◽

Short And Long Term

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Ovarian Dysfunction in Fetally Irradiated Beagles

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100080717 ◽

1977 ◽

Vol 35 ◽

pp. 658-659

Author(s):

T. M. Seed ◽

M. H. Sanderson ◽

D. L. Gutzeit ◽

T. E. Fritz ◽

D. V. Tolle ◽

...

Keyword(s):

Gamma Rays ◽

Low Dose ◽

Long Term Effects ◽

Ovarian Dysfunction ◽

Dose Rates ◽

Highly Sensitive ◽

Microscopic Evaluation ◽

Ovarian Pathology ◽

Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

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