scholarly journals Long-term effects of perinatal exposure to low doses of cadmium on the prostate of adult male rats

2016 ◽  
Vol 97 (4) ◽  
pp. 310-316 ◽  
Author(s):  
Viviane P. Santana ◽  
Évila S. Salles ◽  
Deborah E. Correa ◽  
Bianca F. Gonçalves ◽  
Silvana G. Campos ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Rats ◽  
Perinatal Exposure ◽  
Low Doses ◽  
Long Term Effects

Perinatal exposure to parasiticide ivermectin: long-term effects on reproductive parameters of adult male rats

2011 ◽  
Vol 93 (2) ◽  
pp. 345-351
Author(s):  
Eduardo Wladimir Avilés Terneux ◽  
Davi Abeid Pontes ◽  
Carla Dal Bianco Fernandez ◽  
Arielle Cristina Arena ◽  
Elaine Manoela Porto ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Rats ◽  
Perinatal Exposure ◽  
Reproductive Parameters ◽  
Long Term Effects

scholarly journals Prenatal Stress Induces Long-Term Effects in Cell Turnover in the Hippocampus-Hypothalamus-Pituitary Axis in Adult Male Rats

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e27549 ◽  
Author(s):  
Eva Baquedano ◽  
Cristina García-Cáceres ◽  
Yolanda Diz-Chaves ◽  
Natalia Lagunas ◽  
Isabel Calmarza-Font ◽  
...  
Keyword(s):  
Adult Male ◽  
Prenatal Stress ◽  
Male Rats ◽  
Cell Turnover ◽  
Long Term Effects

Semen parameters, fertility and testosterone levels in male rats exposed prenatally to betamethasone

2009 ◽  
Vol 21 (5) ◽  
pp. 634 ◽  
Author(s):  
Renata C. Piffer ◽  
Patrícia C. Garcia ◽  
Daniela C. C. Gerardin ◽  
Wilma G. Kempinas ◽  
Oduvaldo C. M. Pereira
Keyword(s):  
Adult Male ◽  
Sperm Quality ◽  
Male Offspring ◽  
Male Rats ◽  
Semen Parameters ◽  
Plasma Testosterone ◽  
Control Group ◽  
Long Term Effects ◽  
Testosterone Levels

The present study investigated the long-term effects of prenatal betamethasone exposure on sperm quality and count, fertility and plasma testosterone levels in adult male rats. Pregnant rats received 0.1 mg kg–1 betamethasone on Days 12, 13, 18 and 19 of pregnancy. This treatment impaired sperm quality, sperm production, fertility and plasma testosterone levels in adult male offspring compared to the control group. Thus, the results of the present study indicate that the long-term effects of prenatal betamethasone exposure may be deleterious to offspring. The consequent decrease in testosterone production during adulthood, in association with damaged semen parameters, may explain for the observed decrease in the capacity of adult male offspring to themselves generate viable descendants.

Perinatal exposure to insecticide fipronil: effects on the reproductive system in male rats

2017 ◽  
Vol 29 (6) ◽  
pp. 1130 ◽  
Author(s):  
Aline L. de Barros ◽  
Julie H. Bae ◽  
Cibele S. Borges ◽  
Josiane L. Rosa ◽  
Marilia M. Cavariani ◽  
...  
Keyword(s):  
Sperm Motility ◽  
Sperm Quality ◽  
Expression Patterns ◽  
Male Rats ◽  
Perinatal Exposure ◽  
Reproductive Parameters ◽  
Sperm Production ◽  
Long Term Effects ◽  
Pregnant Rats

Fipronil is an insecticide widely used in agriculture, veterinary medicine and public health that has recently been listed as a potential endocrine disrupter. In the present study we evaluated the effects of perinatal exposure to fipronil during the period of sexual brain differentiation and its later repercussions on reproductive parameters in male rats. Pregnant rats were exposed (via gavage) to fipronil (0.03, 0.3 or 3 mg kg–1) from Gestational Day 15 until Postnatal Day 7. Fipronil exposure did not compromise the onset of puberty. In adulthood, there was no effect on organ weight or sperm production. Furthermore, there were no adverse effects on the number of Sertoli cells per seminiferous tubule, testicular and epididymal histomorphometry or histopathology or expression patterns of androgen receptor in the testis. Similarly, no changes were observed in the sexual behaviour or hormone levels. However, in rats exposed to fipronil, changes in sperm motility were observed, with a decrease in motile spermatozoa and an increase in non-mobile spermatozoa, which can compromise sperm quality in these rats. Perinatal exposure to fipronil has long-term effects on sperm parameters, and the epididymis can be a target organ. Additional studies should be undertaken to identify the mechanisms by which fipronil affects sperm motility.

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