Treatment with Aβ42 Binding d-Amino Acid Peptides Reduce Amyloid Deposition and Inflammation in APP/PS1 Double Transgenic Mice

2012 ◽  
pp. 133-152 ◽  
Author(s):  
Thomas van Groen ◽  
Inga Kadish ◽  
Aileen Funke ◽  
Dirk Bartnik ◽  
Dieter Willbold
Keyword(s):  
Amino Acid ◽  
Transgenic Mice ◽  
Amyloid Deposition ◽  
Double Transgenic Mice

Fimbria–Fornix Lesion Does Not Affect APP Levels and Amyloid Deposition in the Hippocampus of APP+PS1 Double Transgenic Mice

2002 ◽  
Vol 177 (2) ◽  
pp. 565-574 ◽  
Author(s):  
Li Liu ◽  
Sami Ikonen ◽  
Tero Tapiola ◽  
Heikki Tanila ◽  
Thomas van Groen
Keyword(s):  
Transgenic Mice ◽  
Amyloid Deposition ◽  
Double Transgenic Mice

O3-06-01: Oral treatment with an Aβ 42 oligomer modulating D-amino acid peptide improves cognitive behavior of APP/ PS1 double transgenic mice

2009 ◽  
Vol 5 (4S_Part_5) ◽  
pp. P137-P137
Author(s):  
Dieter Willbold ◽  
Thomas van Groen ◽  
Inga Kadish ◽  
Dirk Bartnik ◽  
Luitgard Nagel-Steger ◽  
...  
Keyword(s):  
Amino Acid ◽  
Transgenic Mice ◽  
Oral Treatment ◽  
Cognitive Behavior ◽  
Amino Acid Peptide ◽  
Double Transgenic Mice

Oral treatment with an Abeta42 oligomer modulating D-amino acid peptide modulates memory deficits of APP/ PS1 double transgenic mice

2009 ◽  
Vol 2009 (Spring) ◽  
Author(s):  
Dieter Willbold ◽  
Susanne Aileen Funke ◽  
Thomas van Groen ◽  
Inga Kadish ◽  
Dirk Bartnik ◽  
...  
Keyword(s):  
Amino Acid ◽  
Transgenic Mice ◽  
Oral Treatment ◽  
Memory Deficits ◽  
Amino Acid Peptide ◽  
Double Transgenic Mice

Modulation of T-Cell Functions in KIR2DL3 (CD158b) Transgenic Mice

Blood ◽  
1999 ◽  
Vol 94 (7) ◽  
pp. 2396-2402 ◽  
Author(s):  
Anna Cambiaggi ◽  
Sylvie Darche ◽  
Sophie Guia ◽  
Philippe Kourilsky ◽  
Jean-Pierre Abastado ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Transgenic Mice ◽  
T Cell Activation ◽  
Cell Activation ◽  
Killer Cell ◽  
In Vitro Proliferation ◽  
Cell Functions ◽  
Double Transgenic Mice

In humans, a minor subset of T cells express killer cell Ig-like receptors (KIRs) at their surface. In vitro data obtained with KIR+ β and γδ T-cell clones showed that engagement of KIR molecules can extinguish T-cell activation signals induced via the CD3/T-cell receptor (TCR) complex. We analyzed the T-cell compartment in mice transgenic for KIR2DL3 (Tg-KIR2DL3), an inhibitory receptor for HLA-Cw3. As expected, mixed lymphocyte reaction and anti-CD3 monoclonal antibody (MoAb)-redirected cytotoxicity exerted by freshly isolated splenocytes can be inhibited by engagement of transgenic KIR2DL3 molecules. In contrast, antigen and anti-CD3 MoAb-induced cytotoxicity exerted by alloreactive cytotoxic T lymphocytes cannot be inhibited by KIR2DL3 engagement. In double transgenic mice, Tg-KIR2DL3 × Tg-HLA-Cw3, no alteration of thymic differentiation could be documented. Immunization of double transgenic mice with Hen egg white lysozime (HEL) or Pigeon Cytochrome-C (PCC) was indistinguishable from immunization of control mice, as judged by recall antigen-induced in vitro proliferation and TCR repertoire analysis. These results indicate that KIR effect on T cells varies upon cell activation stage and show unexpected complexity in the biological function of KIRs in vivo.

scholarly journals Evidence for Premature Lipid Raft Aging in APP/PS1 Double-Transgenic Mice, a Model of Familial Alzheimer Disease

2012 ◽  
Vol 71 (10) ◽  
pp. 868-881 ◽  
Author(s):  
Noemí Fabelo ◽  
Virginia Martín ◽  
Raquel Marín ◽  
Gabriel Santpere ◽  
Ester Aso ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Transgenic Mice ◽  
Lipid Raft ◽  
Familial Alzheimer Disease ◽  
Double Transgenic Mice

Gender differences in the amount and deposition of amyloidβ in APPswe and PS1 double transgenic mice

2003 ◽  
Vol 14 (3) ◽  
pp. 318-327 ◽  
Author(s):  
Jun Wang ◽  
Heikki Tanila ◽  
Jukka Puoliväli ◽  
Inga Kadish ◽  
Thomas van Groen
Keyword(s):  
Gender Differences ◽  
Transgenic Mice ◽  
Double Transgenic Mice
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