Signaling Pathway of β -Adrenergic Receptor in Astrocytes and its Relevance to Brain Edema

2017 ◽  
pp. 257-271
Author(s):  
Baoman Li ◽  
Dan Song ◽  
Ting Du ◽  
Alexei Verkhratsky ◽  
Liang Peng
Keyword(s):  
Signaling Pathway ◽  
Brain Edema ◽  
Adrenergic Receptor

scholarly journals β-Adrenergic receptor stimulated Ncx1 upregulation is mediated via a CaMKII/AP-1 signaling pathway in adult cardiomyocytes

2010 ◽  
Vol 48 (2) ◽  
pp. 342-351 ◽  
Author(s):  
Santhosh K. Mani ◽  
Erin A. Egan ◽  
Benjamin K. Addy ◽  
Michael Grimm ◽  
Harinath Kasiganesan ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Adrenergic Receptor ◽  
Adult Cardiomyocytes

scholarly journals The Alpha1B-Adrenergic Receptor Subtype Activates the Phospholipase C Signaling Pathway in Rat Myometrium at Parturition1

1997 ◽  
Vol 57 (5) ◽  
pp. 1175-1182 ◽  
Author(s):  
Isabelle Limon-Boulez ◽  
Sakina Mhaouty-Kodja ◽  
Noëlline Coudouel ◽  
Amelie Benoit de Coignac ◽  
Chantal Legrand ◽  
...  
Keyword(s):  
Phospholipase C ◽  
Signaling Pathway ◽  
Adrenergic Receptor ◽  
Receptor Subtype

scholarly journals 17β-Estradiol Attenuates Intracerebral Hemorrhage-Induced Blood–Brain Barrier Injury and Oxidative Stress Through SRC3-Mediated PI3K/Akt Signaling Pathway in a Mouse Model

ASN NEURO ◽  
2021 ◽  
Vol 13 ◽  
pp. 175909142110384
Author(s):  
Han Xiao ◽  
Jianyang Liu ◽  
Jialin He ◽  
Ziwei Lan ◽  
Mingyang Deng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Brain Injury ◽  
Mouse Model ◽  
Intracerebral Hemorrhage ◽  
Signaling Pathway ◽  
Brain Edema ◽  
Akt Signaling ◽  
Neurological Deficits ◽  
Akt Signaling Pathway ◽  
And Oxidative Stress

Estrogen is neuroprotective in brain injury models, and steroid receptor cofactor 3 (SRC3) mediates estrogen signaling. We aimed to investigate whether and how SRC3 is involved in the neuroprotective effects of 17ß-estradiol (E2) in a mouse model of intracerebral hemorrhage (ICH). Ovariectomized female mice were treated with E2 after autologous blood injection-induced ICH. Brain damage was assessed by neurological deficit score, brain water content, and oxidative stress levels. Blood–brain barrier (BBB) integrity was evaluated by Evan's blue extravasation and claudin-5, ZO-1, and occludin levels. SRC3 expression and PI3K/Akt signaling pathway were examined in ICH mice treated with E2. The effect of SRC3 on E2-mediated neuroprotection was determined by examining neurological outcomes in SRC3-deficient mice undergone ICH and E2 treatment. We found that E2 alleviated ICH-induced brain edema and neurological deficits, protected BBB integrity, and suppressed oxidative stress. E2 enhanced SRC3 expression and PI3K-/Akt signaling pathway. SRC3 deficiency abolished the protective effects of E2 on ICH-induced neurological deficits, brain edema, and BBB integrity. Our results suggest that E2 suppresses ICH-induced brain injury and SRC3 plays a critical role in E2-mediated neuroprotection.

scholarly journals A novel signaling pathway for β‐adrenergic receptor‐mediated activation of PI3K in H9c2 cardiomyocytes

2007 ◽  
Vol 21 (6) ◽  
Author(s):  
Yi‐Tang Tseng ◽  
Naohiro Yano ◽  
Vlad Ianus ◽  
Andy Tseng ◽  
Ting C Zhao ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Adrenergic Receptor ◽  
H9c2 Cardiomyocytes

scholarly journals Regulation of the β-Adrenergic Receptor Signaling Pathway in Sustained Ligand-Activated Preconditioning

2019 ◽  
Vol 369 (1) ◽  
pp. 37-46 ◽  
Author(s):  
L. E. See Hoe ◽  
S. R. Foster ◽  
L. Wendt ◽  
H. H. Patel ◽  
J. P. Headrick ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Adrenergic Receptor ◽  
Receptor Signaling ◽  
Receptor Signaling Pathway
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