The bone organ system: form and function

Author(s):  
Elise F. Morgan ◽  
Louis C. Gerstenfeld
Osteoporosis ◽  
2008 ◽  
pp. 3-25 ◽  
Author(s):  
ELISE F. MORGAN ◽  
GEORGE L. BARNES ◽  
THOMAS A. EINHORN

Author(s):  
Elise F. Morgan ◽  
George L. Barnes ◽  
Thomas A. Einhorn

<em>Abstract</em>.—Fish embryos and larvae are developing, not static, organisms before metamorphosis or transformation to the juvenile form. The means by which embryos and larvae meet physiological challenges posed by their environments and the extent to which evolution shapes the outcome of development is only partially understood. An understanding of these issues can only be approached by coupling the development of form and function over the broad phylogenetic span of fishes. Much work has come forward that describes the development of body form and organ systems, while equally valuable, but often separate, work has emerged that describes the physiology of embryos and larvae. Far fewer composite studies that couple developing form with function are available, and fewer yet have addressed such questions as when, and in what capacity, do developing organs or organ systems function. The evolutionary question also requires a phylogenetic perspective. The reviews that follow this introduction will present current thought that reflects upon the following questions: (1) when is the onset of organ (or organ system) development, and in what physiological capacity do these systems operate among fish embryos and larvae; and (2) are there morphological and physiological specializations that are unique to embryonic and larval fishes, and what are these specializations?


2015 ◽  
Vol 64 ◽  
pp. 81-86 ◽  
Author(s):  
Kentaro Oki ◽  
Timothy D. Law ◽  
Anne B. Loucks ◽  
Brian C. Clark

2014 ◽  
Vol 34 (46) ◽  
pp. 15170-15177 ◽  
Author(s):  
J. S. Satterlee ◽  
M. Basanta-Sanchez ◽  
S. Blanco ◽  
J. B. Li ◽  
K. Meyer ◽  
...  

Author(s):  
Patricia G. Arscott ◽  
Gil Lee ◽  
Victor A. Bloomfield ◽  
D. Fennell Evans

STM is one of the most promising techniques available for visualizing the fine details of biomolecular structure. It has been used to map the surface topography of inorganic materials in atomic dimensions, and thus has the resolving power not only to determine the conformation of small molecules but to distinguish site-specific features within a molecule. That level of detail is of critical importance in understanding the relationship between form and function in biological systems. The size, shape, and accessibility of molecular structures can be determined much more accurately by STM than by electron microscopy since no staining, shadowing or labeling with heavy metals is required, and there is no exposure to damaging radiation by electrons. Crystallography and most other physical techniques do not give information about individual molecules.We have obtained striking images of DNA and RNA, using calf thymus DNA and two synthetic polynucleotides, poly(dG-me5dC)·poly(dG-me5dC) and poly(rA)·poly(rU).


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