Noninvasive Prenatal Testing by Cell-Free DNA: Technology, Biology, Clinical Utility, and Limitations

2019 ◽  
pp. 627-652
Author(s):  
Francesca Romana Grati ◽  
Komal Bajaj ◽  
Giuseppe Simoni ◽  
Federico Maggi ◽  
Susan J. Gross ◽  
...  
Keyword(s):  
Clinical Utility ◽  
Prenatal Testing ◽  
Noninvasive Prenatal Testing ◽  
Cell Free Dna ◽  
Free Dna ◽  
Dna Technology

Nonreportable rates and cell‐free DNA profiles in noninvasive prenatal testing among women with heparin treatment

2020 ◽  
Vol 40 (7) ◽  
pp. 838-845
Author(s):  
Noriyuki Nakamura ◽  
Aiko Sasaki ◽  
Masashi Mikami ◽  
Miyuki Nishiyama ◽  
Rina Akaishi ◽  
...  
Keyword(s):  
Prenatal Testing ◽  
Noninvasive Prenatal Testing ◽  
Cell Free Dna ◽  
Free Dna ◽  
Heparin Treatment ◽  
Dna Profiles

scholarly journals An online tool for fetal fraction prediction based on direct size distribution analysis of maternal cell-free DNA

BioTechniques ◽  
2020 ◽  
Author(s):  
Luca Bedon ◽  
Josef Vuch ◽  
Simeone Dal Monego ◽  
Germana Meroni ◽  
Vanna Pecile ◽  
...  
Keyword(s):  
Size Distribution ◽  
Prenatal Testing ◽  
Distribution Analysis ◽  
Blood Draw ◽  
Noninvasive Prenatal Testing ◽  
Cell Free Dna ◽  
Maternal Cell ◽  
Fetal Dna ◽  
Free Dna ◽  
Fetal Fraction

The discovery of circulating fetal DNA in the plasma of pregnant women has greatly promoted advances in noninvasive prenatal testing. Screening performance is enhanced with higher fetal fraction and analysis of samples whose fetal DNA fraction is lower than 4% are unreliable. Although current approaches to fetal fraction measurement are accurate, most of them are expensive and time consuming. Here we present a simple and cost-effective solution that provides a quick and reasonably accurate fetal fraction by directly evaluating the size distribution of circulating DNA fragments in the extracted maternal cell-free DNA. The presented approach could be useful in the presequencing stage of noninvasive prenatal testing to evaluate whether the sample is suitable for the test or a repeat blood draw is recommended.

scholarly journals Noninvasive prenatal testing from cell-free DNA

2014 ◽  
Vol 186 (12) ◽  
pp. 934-934
Author(s):  
C. M. Armour ◽  
S. M. Nikkel
Keyword(s):  
Prenatal Testing ◽  
Noninvasive Prenatal Testing ◽  
Cell Free Dna ◽  
Free Dna

scholarly journals Value of increased nuchal translucency in the era of noninvasive prenatal testing with cell‐free DNA

2019 ◽  
Vol 145 (3) ◽  
pp. 319-323 ◽  
Author(s):  
Iris Holzer ◽  
Peter W. Husslein ◽  
Dieter Bettelheim ◽  
Julia Scheidl ◽  
Herbert Kiss ◽  
...  
Keyword(s):  
Prenatal Testing ◽  
Nuchal Translucency ◽  
Noninvasive Prenatal Testing ◽  
Cell Free Dna ◽  
Free Dna ◽  
Increased Nuchal Translucency

scholarly journals Microarray-Based Cell-Free DNA Analysis Improves Noninvasive Prenatal Testing

2014 ◽  
Vol 36 (4) ◽  
pp. 282-286 ◽  
Author(s):  
Kara Juneau ◽  
Patrick E. Bogard ◽  
Stephanie Huang ◽  
Morassa Mohseni ◽  
Eric T. Wang ◽  
...  
Keyword(s):  
Dna Analysis ◽  
Prenatal Testing ◽  
Noninvasive Prenatal Testing ◽  
Cell Free Dna ◽  
Free Dna
Sign in / Sign up

Export Citation Format

Share Document