Impact of helicobacter pylori on human physiology and digestive disorders

Abstract Background Helicobacter pylori is accounted as the most etiologic agent for digestive disorders, in particular, the most important of them i.e. peptic ulcer and gastric cancer. In the recent years, association of vacA genotypes and gastrointestinal disorders has attracted a lot of attention. In present study, we assessed the correlation between vacA genotypes (s1, s2, m1, m2, s1m1, s1m2, s2m1 and s2m2) and development to peptic ulcer in Iranian population. Methods In our study, first, 23 original articles containing of information of 3328 patients were evaluated. Statistical analysis was done by Comprehensive Meta-Analysis version 2.0 software (Biostat, Englewood, NJ, USA). In this regards, we used from fixed-effects model for analysis of data with low heterogeneity, while for analysis of data with high heterogeneity (I2 statistic index > 25%, Cochrane Q statistic p value < 0.05), random-effects model was used. Results Abundance of each of s1, s2, m1, m2, s1m1, s1m2, s2m1, and s2m2 was estimated 36.24%, 28.32%, 42.90% 29.86%, 27.88%, 32.34%, 15.70%, and 25.94%, respectively. According to the results, the m1, s1, and s1m2 genotypes were among the most prevalent genotypes among the Iranian patients, whereas, s2m1 genotype had the lowest frequency. Conclusions Finally, we demonstrated that there is a significant relationship between infection of stomach with m1, s1m1, and s2m1 genotypes and development to peptic ulcer.

Download Full-text

Prevalence of Pathogenic Genes cagA and vacA of Helicobacter pylori Isolated in Patients with Digestive disorders from 5 Azar Hospital in Gorgan city in 2017.

Iranian Journal of Medical Microbiology ◽

10.30699/ijmm.13.1.80 ◽

2019 ◽

Vol 13 (1) ◽

pp. 80-88

Author(s):

Khatoon Heidari ◽

Hamed Kaboosi ◽

Ailar Jamali ◽

Ezzat Allah Ghaemi ◽

Fatemeh Peyravii Ghadikolaii ◽

...

Keyword(s):

Helicobacter Pylori ◽

Pathogenic Genes ◽

Digestive Disorders

Download Full-text

Epidemiological aspects of Helicobacter pylori infection in children

ACTUAL INFECTOLOGY ◽

10.22141/2312-413x.9.1.2021.228824 ◽

2021 ◽

Vol 9 (1) ◽

pp. 28-32

Author(s):

T.V. Sorokman ◽

P.M. Moldovan ◽

N.O. Popelyuk ◽

I.V. Parfyonova

Keyword(s):

Helicobacter Pylori ◽

Bacterial Infections ◽

Statistical Data ◽

Duodenal Mucosa ◽

Annual Reports ◽

Direct Link ◽

Maternal Line ◽

Nodular Gastritis ◽

Digestive Disorders ◽

Ulcerative Lesions

Background. Among bacterial infections those caused by Helicobacter pylori (H.pylori) have a special place. H.pylori infection is more common in childhood and is usually asymptomatic. The study of regional and subregional features of H.pylori infection in children is becoming increasingly important. Materials and methods. A retrospective analysis of statistical data of annual reports for 5 years (2015–2019) was conducted on the basis of gastroenterological hospitals in Chernivtsi. Results. For the last 5 years, gastroduodenal diseases were most common in the structure of digestive disorders. Since 2013, 916 children (45.5 %) have been diagnosed with H.pylori infection, its frequency increases with age and is sex-dependent. It was found that in 759 (82.8 %) children with a positive test for H.pylori, diseases of the stomach and duodenum were diagnosed in first- and second-degree relatives, more often through the maternal line — in 455 (59.9 %) people. There is a direct link between endoscopic nodular gastritis and H.pylori infection. Conclusions. The prevalence of H.pylori among the child population of Chernivtsi region is 45.5 %. H.pylori infection is a disease of different periods of childhood with predominance in girls and is accompanied by lesions of the gastric and duodenal mucosa, its frequency increases with age of children that is accompanied by an increase in erosive-ulcerative lesions.

Download Full-text

The rod-to-coccoid body transformation in cultures of Helicobacter pylori

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100160686 ◽

1990 ◽

Vol 48 (3) ◽

pp. 626-627

Author(s):

A. R. Crooker ◽

W. G. Kraft ◽

T. L. Beard ◽

M. C. Myers

Keyword(s):

Helicobacter Pylori ◽

Growth Cycle ◽

Negative Bacterium ◽

Body Formation ◽

Coccoid Form ◽

Spiral Form ◽

Prolonged Culture ◽

H Pylori ◽

Upper Gastrointestinal

Helicobacter pylori is a microaerophilic, gram-negative bacterium found in the upper gastrointestinal tract of humans. There is strong evidence that H. pylori is important in the etiology of gastritis; the bacterium may also be a major predisposing cause of peptic ulceration. On the gastric mucosa, the organism exists as a spiral form with one to seven sheathed flagella at one (usually) or both poles. Short spirals were seen in the first successful culture of the organism in 1983. In 1984, Marshall and Warren reported a coccoid form in older cultures. Since that time, other workers have observed rod and coccal forms in vitro; coccoid forms predominate in cultures 3-7 days old. We sought to examine the growth cycle of H. pylori in prolonged culture and the mode of coccoid body formation.

Download Full-text