By taking combustion synthesis in high-gravity field to achieve fusion bonding of TiB2-based ceramic, Ti-6Al-4V alloy, the mid-ceramic and 42CrMo steel simultaneously, the ceramic-metal FG multilayer composites with the continuously-graded interfacial microstructures were successfully fabricated. XRD, FESEM and EDS results showed the formation of continuously-graded interfacial microstructures among TiB2-based ceramic, Ti-6Al-4V alloy, the mid-ceramic and 42CrMo steel resulted from thermal explosion reaction caused by high gravity field, liquid fusion of the ceramic, Ti-6Al-4V alloy, the mid-ceramic and 42CrMo steel, so hard-by-soft distribution in the hardness of FG multilayer composite was presented, and the interfacial shear strength of TiB2-based ceramic and Ti-6Al-4V alloy, and the mid-ceramic and 42CrMo steel measured 198 ± 25 MPa and 130 ± 15 MPa, respectively.