Molecular aspects of Ewing's sarcomas

2022 ◽  
pp. 617-630
Author(s):  
Franck Tirode ◽  
Thomas G.P. Grünewald
Keyword(s):  
1977 ◽  
Vol 38 (03) ◽  
pp. 0724-0727 ◽  
Author(s):  
H Graeff ◽  
R Hafter ◽  
R von Hugo

2018 ◽  
Vol 22 (5) ◽  
pp. 9-16 ◽  
Author(s):  
M. Z. Gasanov

In recent decades, the main pathogenetic mechanisms for maintaining muscle mass and strength have been discovered. Most of the scientific papers on the molecular aspects of the  pathogenesis of sarcopenia were focused on the Akt-signaling  pathway. The subject of the study were people of elderly and senile  age, immobilized patients, patients with CKD 1-4 stages, animals. However, recently more attention has been paid to the role  of protein – the mammalian target of rapamycin mTOR. It seems to be a key link in the control of muscle mass and is a promising  marker in understanding the mechanisms of the pathogenesis of  sarcopenia. Its importance in protein metabolism in patients with  end stage kidney disease is not studied and requires further research. The presented scientific review contains  information on the role of mTOR and its components – mTORC1 and mTORC2 in maintaining muscle mass and strength in a healthy  person and in the formation of sarcopenia in patients with CKD. The  general aid of mTORC1 complex is regulation of protein production  which is necessary for cell growth and differentiation. mTORC2  complex functions are not enough studied. It is established that it  plays important role in such biological processes as cytoskeleton  organization, intracellular homeostasis maintaining, so it provides  cell resistance and cell survivability in negative external and internal  impulses. mTOR protein can be considered as promising molecular  marker in diagnostics of protein metabolism early disturbances in  patients with CKD and also as additory factor of sarcopenia severity assessment.


HortScience ◽  
1998 ◽  
Vol 33 (3) ◽  
pp. 555d-555
Author(s):  
J.L. Olsen ◽  
S.A. Mehlenbacher ◽  
A.N. Azarenko

Hazelnuts are wind-pollinated, monoecious, mostly dichogamous, and self-incompatible of the sporophytic type. About 90% of the cultivars studied are protandrous. Anthesis of the pistillate flower is temperature-dependent and occurs from December through February, with its peak in January. Stigmatic surfaces may remain receptive for up to 3 months. Four to 5 months separate pollination and fertilization of the ovule, which usually occurs between mid-May and the end of June in Oregon. A 10% pollinizer density has been the standard, with a recommended distance of <20 m between the main cultivar and the nearest pollinizer. Two or three different pollinizer varieties with different times of pollen shed are recommended. The Oregon hazelnut industry is presently combating the fungal disease, Eastern Filbert Blight, Anisogramma anomala. Part of the current management recommendations are to reduce the susceptible pollinizer varieties to a density of around 5%, and then gradually replace those left with immune or more-resistant genotypes. Recent research by S.A. Mehlenbacher refined methods of using fluorescense microscopy to quickly determine genotype compatibility. The self-incompatiblity is controlled by a single gene with multiple alleles. The biochemical, physiological, and molecular aspects of sporophytic self-incompatiblity are being research by A.N. Azarenko.


2015 ◽  
Vol 9 (2) ◽  
pp. 141-147 ◽  
Author(s):  
Anna D'Angelillo ◽  
Stefania Staibano ◽  
Michele Russo ◽  
Maria F. Romano ◽  
Simona Romano
Keyword(s):  

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