Review of the research programme on the Mortella III wreck (2010-2020, Corsica, France): A contribution to the knowledge of the Mediterranean naval architecture and material culture of the Renaissance.

The Mortella wrecks are the remains of two navi, Genoese seagoing merchant ships, sunk in 1527 in the Bay of Saint-Florent (Upper-Corsica, France) during the Seventh Italian War. A programme of archaeological excavations and historical research has been held on one of them, Mortella III, between 2010 and 2020. It has involved a multidisciplinary team around a European research project called ModernShip (Horizon 2020), whose objective is to shed light on Mediterranean shipbuilding during the Renaissance, a field still little known to this day. At the end of these 10 years, the aim of the present article is to conclude this research programme with the presentation of a scientific review that complements a recently published monograph on the Mortella III wreck. This study presents the latest results on the ship's architecture obtained during the excavation of the wreck in 2019, including a study of the wood of the framework. Finally, this article broadens our understanding of the nave presenting the results of a collaborative line of research on material culture with three studies in close connection with the ship architecture: artillery, anchors and ceramics.

Importance of using a pharmacogenetic approach to predict individual pharmacokinetics and safety profile of apixaban

In recent years, there has been a trend towards increased prescribing of direct-acting oral anticoagulants (DOACs) due to favourable pharmacokinetics and pharmacodynamics without the need for regular coagulation monitoring. However, recent studies have documented individual variability in plasma DOAC levels. DOAC pharmacogenetics is a relatively new area of research. There is a need to understand the role of pharmacogenetics in the adaptation of anticoagulant therapy according to a patient’s genetic characteristics. This scientific review of current data on the impact of different gene polymorphisms on apixaban pharmacokinetics broadens the understanding of the clinical relevance of genotyping for treatment efficacy and safety.

Botulinum Toxins for Aesthetic Facial Injections – A scientific review to support evidence-based best practice.

Botulinum Toxins (BoNT) are complex biological products. Each licensed BoNTA has its own individual characteristics resulting into different attributes, some of them being of clinical relevance. Besides profound anatomical knowledge and understanding of aesthetic principles, the responsible injecting physician should be aware of those pharmaceutical and clinical properties. Especially against the background of new BoNTA formulations receiving approval by the authorities a critical and dedicated discussion on the individual characteristics should take place and the potential relevance on the treatment outcome should be taken into consideration.

Awareness on COVID 19 vaccination among public: a questionnaire surveys

Background: Coronavirus disease 2019 or Coronavirus disease 2019 (COVID-19) is caused by a newly discovered coronavirus, Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2 become the major threat to public health. Several vaccines have been approved for use against coronavirus disease and distributed globally in different regions. Thus, the study aimed to assess the knowledge, attitudes and awareness towards COVID-19 vaccination among the general population in Chengalpet district, Tamil nadu.Methods: A cross sectional study was conducted in the year of 2021 from department of Public Health Dentistry, among 274 participants who are residing in Chengalpet district. Study approval is being obtained from Institutional Scientific Review Board Asan Memorial Dental College and Hospital. People above 18 years of age were included in the study. Self administered validated questionnaire which consists of data on demographic profile followed by assessing COVID-19 related information, acceptance, attitude and awareness on COVID-19 vaccine were assessed.Results: A questionnaire survey was conducted among N=274 adults, aged above 18 years, in the present study, n=142 (51.8%) were male and n=132 (48.2%) were female. The majority of n=225 (82.1%) participants showed good knowledge, awareness and attitude towards covid-19 vaccine and almost n=210 (76.6%) were willing to take the vaccine without hesitation. Although maximum respondents demonstrated a good level of knowledge and acceptance, significant differences were observed across gender.Conclusions: The findings reflect satisfactory knowledge and positive attitudes towards COVID-19 vaccine among the general population. Awareness campaigns, feedback from vaccinated individuals about the safety will encourage the COVID-19 vaccine acceptance.

The place of the discipline “Fundamentals of Stage Movement: Historical Etiquette” in the professional training of a modern actor and its connection with the subjects of professional and practical cycle

The actor’s flexibility and stretching expressiveness is one of the most important skills in acquiring professional knowledge, which is taken into account in the structure of the pedagogical process of theatrical performances, where a significant role is given to the disciplines of the flexibility and stretching cycle, in particular the basics of stage movement, one of the components of which is historical etiquette, which develops the psychophysical apparatus of the actor in the way necessary for stage activities, trains a sense of beauty and elegance of movement, form and style. However, for today the specific character of mastering stylistic behaviour requires careful scientific review in order to create a modern study of the role of historical etiquette in the flexibility and stretching culture of the actor and the place of discipline in the cycle of professional and practical training, which determines the relevance of this article. The purpose of the paper is to substantiate the importance of mastering stylistic behaviour by a future professional actor in the context of the discipline “Fundamentals of Stage Movement” and general professional training. The methodology. In this article we applied the methods of abstraction and structuring, analytical and comparative methods within the pedagogical approach. The results. The subject “Fundamentals of Stage Movement: Historical Etiquette” is an important component of the system of modern professional training of the future actor, which meets the requirements of modern theatrical art that tends to flexibility and stretching means of expression and nonverbal language. By mastering the specific features of stylistic behaviour and flexibility and stretching of different historical epochs, the future actor acquires appropriate professional competencies and is able not only to accurately embody any historical image, but also to improve the unity of interior and exterior technology, increase the overall level of flexibility and stretching culture, expand the range techniques, to acquire skills of creating flexibility and stretching characteristic features of contemporary images, to reveal creative potential and to realize it more widely while mastering related disciplines (“Actor’s Skill”, “Dance”, “Stage Fight”, “Fencing”, “Stage Language”, “Vocal”) , which will make it in demand in further professional activities in both theatre and film industries. The scientific novelty. The paper is the first attempt for substantiating the necessity of studying the stylistic behaviour and historical etiquette by future actors in the context of further realization of their creative potential in professional activity. The practical significance. The materials of the article can be used in the practical activities of teachers of stage movement and in creating further research in this area.

Attitude and Views towards Mental Health among Dental Students

Introduction: Stress can be a feeling of emotional or physical tension. It can come from any event or thought that can make us feel frustrated, angry, or nervous. Stress is your body's reaction to a challenge or demands. Aim: The aim of the study is to assess attitude and views towards mental health and psychiatry among dental students. Materials and Methods: Study Setting is prospective observational study.The advantages of this study was economical, easy to create, wide reach, and gathering larger data Quick Interpretation . It was approved by the scientific review Board Saveetha Dental college Chennai .Number of participants involved in this study are 138 college students .The responses from the google sheet were transferred into excel. Inferential statistics was done using Chi square test and exported to SPSS software, version 25 Results: From the survey conducted among dental students on mental health and psychiatry.Majority of dental students were female participants compared male participants.Interpretation was based on a p value less than 0.05, which was considered to be statistically significant. Conclusion: The findings of the present study proves that the majority of dental students have awareness of attitudes and views of mental health .Among dental students, females are the major participants compared to males. In order to develop psychiatric and mental health services, public acceptance is necessary.

Exploring the experiences of stroke survivors, informal caregivers and healthcare providers in Sierra Leone: a qualitative study protocol

IntroductionStroke is now the second leading cause of adult death in Sub-Saharan Africa. Developed in dialogue with stroke survivors and caregivers in Sierra Leone, this will be the first study to explore the experience of stroke as well as the perceptions of the barriers and facilitators to accessing stroke care among stroke survivors, informal caregivers and healthcare providers. Findings will inform future stroke research and care in Sierra Leone.Methods and analysisA cross-sectional qualitative study employing semistructured interviews that will be audiorecorded, translated, transcribed and coded.SettingFreetown, Sierra Leone.ParticipantsInterviews with a purposive sample of stroke survivors, informal caregivers and healthcare providers.AnalysisInterviews will be coded by two authors and inductively analysed using thematic analysis.Ethics and disseminationThis study has received ethical approval from the Sierra Leone Ethics and Scientific Review Committee (8 December 2020) and the KCL Biomedical & Health Sciences, Dentistry, Medicine and Natural & Mathematical Sciences Research Ethics Subcommittee (reference: HR-20/21-21050). The findings of the study and learning in terms of the process of coproduction and involvement of stroke survivors will be disseminated via peer-reviewed publications, conferences, media and lay reports.

Shining a Light Inside the “Black Box” of NIH Application Submission and Review

What happens to applications after they are submitted to the National Institutes of Health, and how can you better prepare yourself and your application for the process of peer review? The Center for Scientific Review (CSR) works closely with the 24 funding institutes and centers at the National Institutes of Health that provide funding support for projects of high scientific merit and high potential impact. CSR conducts the first level of review for the majority of grant applications submitted to the NIH, which includes 90% of R01s, 85% of Fellowships, and 95% of Small Business Innovation Research (SBIR) applications as well as many other research and training opportunity activities. In this capacity, CSR helps to identify the most meritorious projects, cutting-edge research, and future scientists who will advance the mission of the NIH: to enhance health, lengthen life, and reduce illness and disability. The purpose of this project is to provide an overview of 1) what happens to NIH applications before, during, and after peer review at CSR; 2) a summary of new and current peer review policies and practices that impact investigators and their submitted applications; and 3) strategies for developing a strong NIH grant application. Peer review is the cornerstone of the NIH grant supporting process, and an insider’s view can shine a light inside the “Black Box” of how the most meritorious projects are identified.

Visualizing the Knowledge Domain of Motor Speech Disorders: A Scientific Review (2000-2019)

This review visualizes the knowledge domain of motor speech disorders (MSDs) in linguistics between 2000 and 2019 by means of scientometric methods. With topic searches, the study collected 869 bibliographic records and 20, 411 references from Web of Science Core Collection (WoSCC) of Thomson Reuter. The clustered and visualized document co-citation network of the MSDs knowledge domain in CiteSpace identifies 15 research foci in different periods, including apraxia of speech, acoustics, children, technology, aphemia, childhood apraxia of speech, primary progressive aphasia, speech motor delay, Parkinson’s disease, amyotrophic lateral sclerosis, rhythm, foreign accent syndrome, phonation, phonological awareness, dose and speech perception. Revolving around linguistics, these foci could be divided into studies on speech characteristics of MSDs in terms of phonology and phonetics, remedies for MSDs in terms of neurolinguistics and acoustic phonetics, dysarthria secondary to neurological diseases based on pathological linguistics, subtypes of apraxia of speech, methods of MSDs based on auditory phonetics and a newly recognized subtype of MSDs. Meanwhile, the emerging trends of MSDs in linguistics are detected by the analysis of reference citation bursts, suggesting growing research in remedies for MSDs with the focus on assessments and effectiveness of treatments, speech characteristics and indexes of dysarthria secondary to neurological diseases and assistance to diagnose apraxia of speech. To sum up, the review has indicated that the acoustic measures to assess MSDs and acoustic remedies for dysarthria may not only be the past foci but also be future trends.

Meticulous Endorsement of Black Seed and Jambolana: A Scientific Review

The repository of traditional, historical and cultural heritage of natural prophylactic medicine to treat different disease, disorder and its aliment is limitless and time-immemorial. As per the hadith narrated by Ibn Abbas (RA), Prophet Muhammed specifically mentioned about Sulayman (AS) recorded the name and use of many herbal medicinal remedies after construction of his castle (Ibn Asakri’s Mukhtasar Tareekh Dimashq 3.393), in addition to it, Prophet Muhammed use to recommend 65 different herbal prophylactic medicines which are scientifically proved to be highly effective against almost all types of ailments, among this repository of 65, while prescribing the NS Prophet Muhammed narrated “use this black seeds regularly it is having the properties to cure all disease (ailment) except death (An authentic hadith narrated by Abu Hurayrah (RA) and recorded by Bukhari, Muslim Ahmad Ibn Majah). This in-depth review specially articulated to elaborate phytochemical, pharmacological and mechanistic approach to bring out the properties of not only NS but in addition, it focusing on the important properties of EJ. Preliminarily to say NS claim to have anti-inflammatory, analgesic, hepato-protective, neuro-protective, gastro-protective and other useful activity are due to two important constituents Thymoquinone (TQ) and NS oil (NSO). TQ has interaction with human serum albumin. Seeds containing volatile oils mainly Melanthin showed toxicity at larger doses. Whereas, EJ simultaneously proved its effectiveness underutilized fruit, crops are nutritious bearing wide range of pharmaceuticals properties. EJ fruit is highly perishable and is mainly used for the diabetes patients, it is well known as a traditional medicinal plant having essential bioactive compounds which are present in all parts of the plant. The major bioactive compounds present in the EJ roots are phytosterols, flavonoids, carotenoids, myricetin, oxalic acid, gallic acid, citronellol, cyanidin diglucoside, hotrienol, and polyphenols as well as micronutrients having many health benefits. It is also a good source of anthocyanin and effective against numerous health problems and act as chemo-preventive, radioprotective and demonstrating antineoplastic properties. The ripe fruits are pleasant, astringent taste and are eaten either raw or processed into different products mainly vinegar, jam, jellies and squash. The jambolana seed contains alkaloid, jambosine, and glycoside jambolin or antimellin. To be concluded, NS and EJ both bearing similar therapeutic and pharmacological endorsement with different remarkable biological active molecule, which will become future reference to find out the natural way to cure untreatable disease and its disorder such as HIV-Aids, Cancer and recent outbreak, etc. according to narration made by Prophet Muhammed .