The epidermal growth factor system in Caenorhabditis elegans

2003 ◽  
pp. 157-166
Author(s):  
Nadeem Moghal ◽  
Paul W. Sternberg
Keyword(s):  
Caenorhabditis Elegans ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Epidermal Growth ◽  
Factor System

Expression of the Epidermal Growth Factor System in Eutopic Endometrium from Women with Endometriosis Differs from That in Endometrium from Healthy Women

2009 ◽  
Vol 67 (2) ◽  
pp. 118-126 ◽  
Author(s):  
Kirsten Ejskjær ◽  
Boe Sandahl Sorensen ◽  
Steen Seier Poulsen ◽  
Ole Mogensen ◽  
Axel Forman ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Eutopic Endometrium ◽  
Healthy Women ◽  
Epidermal Growth ◽  
Factor System

scholarly journals A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog.

1996 ◽  
Vol 16 (2) ◽  
pp. 529-537 ◽  
Author(s):  
W S Katz ◽  
G M Lesa ◽  
D Yannoukakos ◽  
T R Clandinin ◽  
J Schlessinger ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Caenorhabditis Elegans ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Point Mutation ◽  
Growth Factor Receptor ◽  
Extracellular Domain ◽  
Cysteine Residue ◽  
Loss Of Function ◽  
Epidermal Growth

The let-23 gene encodes a Caenorhabditis elegans homolog of the epidermal growth factor receptor (EGFR) necessary for vulval development. We have characterized a mutation of let-23 that activates the receptor and downstream signal transduction, leading to excess vulval differentiation. This mutation alters a conserved cysteine residue in the extracellular domain and is the first such point mutation in the EGFR subfamily of tyrosine kinases. Mutation of a different cysteine in the same subdomain causes a strong loss-of-function phenotype, suggesting that cysteines in this region are important for function and nonequivalent. Vulval precursor cells can generate either of two subsets of vulval cells (distinct fates) in response to sa62 activity. The fates produced depended on the copy number of the mutation, suggesting that quantitative differences in receptor activity influence the decision between these two fates.

Expression of the epidermal growth factor system in human middle ear cholesteatoma

2013 ◽  
Vol 134 (2) ◽  
pp. 124-134 ◽  
Author(s):  
Mette Bendixen Thorup ◽  
Mathias Munk ◽  
Steen Seier Poulsen ◽  
Michael Gaihede ◽  
Ebba Nexo ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Middle Ear ◽  
Middle Ear Cholesteatoma ◽  
Epidermal Growth ◽  
Factor System ◽  
Human Middle Ear

Expression of the epidermal growth factor system in endometrioid endometrial cancer

2007 ◽  
Vol 104 (1) ◽  
pp. 158-167 ◽  
Author(s):  
Kirsten Ejskjær ◽  
Boe Sandahl Sørensen ◽  
Steen Seier Poulsen ◽  
Axel Forman ◽  
Ebba Nexø ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Epidermal Growth ◽  
Endometrioid Endometrial Cancer ◽  
Factor System

scholarly journals Polarized epidermal growth factor secretion ensures robust vulval cell fate specification in Caenorhabditis elegans

Development ◽  
2020 ◽  
Vol 147 (11) ◽  
pp. dev175760
Author(s):  
Louisa Mereu ◽  
Matthias K. Morf ◽  
Silvan Spiri ◽  
Peter Gutierrez ◽  
Juan M. Escobar-Restrepo ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cell Fate ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Epidermal Growth ◽  
Factor Secretion ◽  
Growth Factor Secretion
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