Investigation of the mechanism of nicotine demethylation in Nicotiana through 2H and 15N heavy isotope effects: Implication of cytochrome P450 oxidase and hydroxyl ion transfer

2007 ◽  
Vol 458 (2) ◽  
pp. 175-183 ◽  
Author(s):  
Roland Molinié ◽  
Renata A. Kwiecień ◽  
Piotr Paneth ◽  
Wilfried Hatton ◽  
Jacques Lebreton ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Isotope Effects ◽  
Ion Transfer ◽  
Heavy Isotope ◽  
Hydroxyl Ion

Elucidation of the mechanism of N-demethylation catalyzed by cytochrome P450 monooxygenase is facilitated by exploiting nitrogen-15 heavy isotope effects

2011 ◽  
Vol 510 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Renata A. Kwiecień ◽  
Roland Molinié ◽  
Piotr Paneth ◽  
Virginie Silvestre ◽  
Jacques Lebreton ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Isotope Effects ◽  
Cytochrome P450 Monooxygenase ◽  
Heavy Isotope ◽  
P450 Monooxygenase

scholarly journals Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0206279 ◽  
Author(s):  
Hao Sun ◽  
David W. Piotrowski ◽  
Suvi T. M. Orr ◽  
Joseph S. Warmus ◽  
Angela C. Wolford ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Reaction Mechanism ◽  
Isotope Effects ◽  
Substrate Dependence ◽  
Deuterium Isotope Effects ◽  
Drug Pharmacokinetics

Kinetic Isotope Effects in a C−H Bond Dissociation by the Iron-Oxo Species of Cytochrome P450

2000 ◽  
Vol 104 (51) ◽  
pp. 12365-12370 ◽  
Author(s):  
Kazunari Yoshizawa ◽  
Yoshihisa Kagawa ◽  
Yoshihito Shiota
Keyword(s):  
Cytochrome P450 ◽  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Bond Dissociation ◽  
Kinetic Isotope

Cytochrome P450-Catalyzed Hydroxylation of Hydrocarbons: Kinetic Deuterium Isotope Effects for the Hydroxylation of an Ultrafast Radical Clock

Biochemistry ◽  
1994 ◽  
Vol 33 (35) ◽  
pp. 10630-10637 ◽  
Author(s):  
Jeffrey K. Atkinson ◽  
Paul F. Hollenberg ◽  
K. U. Ingold ◽  
Cathy C. Johnson ◽  
Marie-Helene Le Tadic ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Isotope Effects ◽  
Radical Clock ◽  
Deuterium Isotope Effects

scholarly journals Cytochrome P450-catalyzed dealkylation of atrazine byRhodococcussp. strain NI86/21 involves hydrogen atom transfer rather than single electron transfer

2014 ◽  
Vol 43 (32) ◽  
pp. 12175-12186 ◽  
Author(s):  
Armin H. Meyer ◽  
Agnieszka Dybala-Defratyka ◽  
Peter J. Alaimo ◽  
Inacrist Geronimo ◽  
Ariana D. Sanchez ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Cytochrome P450 ◽  
Hydrogen Atom ◽  
Isotope Effects ◽  
Hydrogen Atom Transfer ◽  
Single Electron ◽  
Atom Transfer ◽  
Single Electron Transfer ◽  
Position Specificity

Isotope effects and position-specificity of hydroxylation pinpoint hydrogen atom transfer (HAT) as prevailing mechanism in P450 catalyzed N-dealkylation of atrazine.

Isotope effect on the thermodynamic quantities of gaseous uranium hexafluoride

1976 ◽  
Vol 54 (1) ◽  
pp. 160-165 ◽  
Author(s):  
Jan Bron
Keyword(s):  
Partition Function ◽  
Quantum Correction ◽  
Isotope Effects ◽  
Uranium Atom ◽  
Uranium Hexafluoride ◽  
Thermodynamic Quantities ◽  
Heavy Isotope ◽  
Statistical Mechanical ◽  
Lower Temperature ◽  
The Masses

For gaseous UF6 changes in the thermodynamic quantifies ΔG (= ΔA), ΔH (= ΔU), ΔCp (= ΔCv), and ΔS upon isotopic substitution can be determined by using the spectroscopically determined geometry and force field. The differences ΔG etc. are defined as (G238 – Gx), where 238 and x (x = 235, 234, 233, and 232) are the masses of the central uranium atom. The changes in the thermodynamic quantities are related to the logarithm of the partition function ratio of the UF6 species compared. The logarithm of the partition function ratio can be conveniently expressed as a series in temperature and hence, by using statistical mechanical relationships, the changes in thermodynamic quantities can be expressed as a series in temperature.Since these changes form examples of heavy isotope effects the validity and utility of the first quantum correction can be investigated. Uncertainties and trends in the magnitudes of the differences in the thermodynamic quantities due to uncertainties or changes in spectroscopic parameters are discussed by means of the first quantum correction. It has been found that the first quantum correction has little quantitative value in the lower temperature region, but it can be used in that range to explain some observed trends in the isotope effects. Some of the conclusions can also be applied to kinetic and equilibrium heavy isotope effects.

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