Epigallocatechin gallate (EGCG) inhibits type II phosphatidylinositol 4-kinases: A key component in pathways of phosphoinositide turnover

2011 ◽  
Vol 516 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Ranjeet K. Sinha ◽  
Ronak Y. Patel ◽  
Naveen Bojjireddy ◽  
Anindya Datta ◽  
Gosukonda Subrahmanyam
Keyword(s):  
Epigallocatechin Gallate ◽  
Type Ii ◽  
Phosphoinositide Turnover ◽  
Phosphatidylinositol 4

scholarly journals Biphasic regulation of type II phosphatidylinositol-4 kinase by sphingosine: Cross talk between glycero- and sphingolipids in the kidney

2014 ◽  
Vol 1838 (3) ◽  
pp. 1003-1009 ◽  
Author(s):  
Thiago Lemos ◽  
Karine S. Verdoorn ◽  
Luciana Nogaroli ◽  
Thiago Britto-Borges ◽  
Thaís A. Bonilha ◽  
...  
Keyword(s):  
Cross Talk ◽  
Type Ii ◽  
Phosphatidylinositol 4

Nuclear localization of phosphatidylinositol 4-kinase β

2002 ◽  
Vol 115 (8) ◽  
pp. 1769-1775 ◽  
Author(s):  
Petra de Graaf ◽  
Elsa E. Klapisz ◽  
Thomas K. F. Schulz ◽  
Alfons F. M. Cremers ◽  
Arie J. Verkleij ◽  
...  
Keyword(s):  
Nuclear Export ◽  
Kinase Activity ◽  
Insoluble Fraction ◽  
Type Ii ◽  
3T3 Cells ◽  
Type Iii ◽  
Pore Complexes ◽  
Phosphatidylinositol 4 ◽  
Nih 3T3 ◽  
Nih 3T3 Cells

Whereas most phosphatidylinositol 4-kinase (PtdIns 4-kinase) activity is localized in the cytoplasm, PtdIns 4-kinase activity has also been detected in membranedepleted nuclei of rat liver and mouse NIH 3T3 cells. Here we have characterized the PtdIns 4-kinase that is present in nuclei from NIH 3T3 cells. Both type II and type III PtdIns 4-kinase activity were observed in the detergent-insoluble fraction of NIH 3T3 cells. Dissection of this fraction into cytoplasmic actin filaments and nuclear lamina-pore complexes revealed that the actin filament fraction contains solely type II PtdIns 4-kinase,whereas lamina-pore complexes contain type III PtdIns 4-kinase activity. Using specific antibodies, the nuclear PtdIns 4-kinase was identified as PtdIns 4-kinase β. Inhibition of nuclear export by leptomycin B resulted in an accumulation of PtdIns 4-kinase β in the nucleus. These data demonstrate that PtdIns 4-kinase β is present in the nuclei of NIH 3T3 fibroblasts,suggesting a specific function for this kinase in nuclear processes.

scholarly journals A monoclonal antibody distinguishes two types of phosphatidylinositol 4-kinase

1991 ◽  
Vol 273 (1) ◽  
pp. 63-66 ◽  
Author(s):  
G C Endemann ◽  
A Graziani ◽  
L C Cantley
Keyword(s):  
Monoclonal Antibody ◽  
Rat Brain ◽  
Rat Liver ◽  
Bovine Brain ◽  
Human Erythrocytes ◽  
Gene Products ◽  
Type Ii ◽  
Type Iii ◽  
Distinct Gene ◽  
Phosphatidylinositol 4

A monoclonal antibody has been developed against the type II PtdIns 4-kinase from bovine brain. This antibody, 4C5G, causes greater than 90% inhibition of the type II PtdIns 4-kinase from bovine brain, rat brain and human erythrocytes. However, it fails to inhibit type III PtdIns 4-kinase from bovine brain or PtdIns 3-kinase from rat liver. These results suggest that type II and type III PtdIns 4-kinases are distinct gene products, and that 4C5G will be useful in studying the function of the type II PtdIns 4-kinase.

Type II phosphatidylinositol 4-kinases promote Listeria monocytogenes entry into target cells

2007 ◽  
Vol 9 (10) ◽  
pp. 2381-2390 ◽  
Author(s):  
Javier Pizarro-Cerdá ◽  
Bernard Payrastre ◽  
Ying-Jie Wang ◽  
Esteban Veiga ◽  
Helen L. Yin ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Target Cells ◽  
Type Ii ◽  
Phosphatidylinositol 4

scholarly journals Phosphatidylinositol 4-kinase type II  is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles

2003 ◽  
Vol 100 (7) ◽  
pp. 3995-4000 ◽  
Author(s):  
J. Guo ◽  
M. R. Wenk ◽  
L. Pellegrini ◽  
F. Onofri ◽  
F. Benfenati ◽  
...  
Keyword(s):  
Synaptic Vesicles ◽  
Kinase Activity ◽  
Type Ii ◽  
Phosphatidylinositol 4

scholarly journals Type II phosphatidylinositol 4-kinase regulates nerve terminal growth and synaptic vesicle recycling

2018 ◽  
Vol 32 (3) ◽  
pp. 230-235 ◽  
Author(s):  
Kristyn C. Cantarutti ◽  
Jason Burgess ◽  
Julie A. Brill ◽  
Jeffrey S. Dason
Keyword(s):  
Synaptic Vesicle ◽  
Nerve Terminal ◽  
Type Ii ◽  
Synaptic Vesicle Recycling ◽  
Vesicle Recycling ◽  
Phosphatidylinositol 4

Piperine inhibits type II phosphatidylinositol 4-kinases: a key component in phosphoinositides turnover

2014 ◽  
Vol 393 (1-2) ◽  
pp. 9-15 ◽  
Author(s):  
Naveen Bojjireddy ◽  
Ranjeet Kumar Sinha ◽  
Gosukonda Subrahmanyam
Keyword(s):  
Type Ii ◽  
Phosphatidylinositol 4

scholarly journals Association of Protein Kinase Cμ with Type II Phosphatidylinositol 4-Kinase and Type I Phosphatidylinositol-4-phosphate 5-Kinase

1998 ◽  
Vol 273 (36) ◽  
pp. 23126-23133 ◽  
Author(s):  
Kiyotaka Nishikawa ◽  
Alex Toker ◽  
Karen Wong ◽  
Paola A. Marignani ◽  
Franz-Josef Johannes ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Type I ◽  
Type Ii ◽  
Phosphatidylinositol 4
Sign in / Sign up

Export Citation Format

Share Document