Field-amplified sample injection coupled with pseudo-isotachophoresis technique for sensitive determination of selected psychiatric drugs in human urine samples after dispersive liquid–liquid microextraction

2014 ◽  
Vol 811 ◽  
pp. 88-93 ◽  
Author(s):  
Szymon Dziomba ◽  
Piotr Kowalski ◽  
Agata Słomińska ◽  
Tomasz Bączek
Keyword(s):  
Human Urine ◽  
Urine Samples ◽  
Sample Injection ◽  
Human Urine Samples ◽  
Psychiatric Drugs ◽  
Sensitive Determination ◽  
Dispersive Liquid Liquid Microextraction ◽  
Liquid Microextraction

Determination of tetracyclines in human urine samples by capillary electrophoresis in combination with field amplified sample injection

2017 ◽  
Vol 39 (4) ◽  
pp. 608-615 ◽  
Author(s):  
David Moreno-González ◽  
Markéta Krulišová ◽  
Laura Gámiz-Gracia ◽  
Ana M. García-Campaña
Keyword(s):  
Capillary Electrophoresis ◽  
Human Urine ◽  
Urine Samples ◽  
Sample Injection ◽  
Human Urine Samples

scholarly journals Analysis of chlorpheniramine in human urine samples using dispersive liquid-liquid microextraction combined with high-performance liquid chromatography

2014 ◽  
Vol 50 (3) ◽  
pp. 551-557 ◽  
Author(s):  
Mehdi Maham ◽  
Vahid Kiarostami ◽  
Syed Waqif-Husain ◽  
Malihe Khoeini Sharifabadi
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Human Urine ◽  
High Performance ◽  
Low Cost ◽  
Test Tube ◽  
Urine Samples ◽  
Human Urine Samples ◽  
Dispersive Liquid Liquid Microextraction ◽  
Liquid Microextraction

A simple and environmentally friendly microextraction technique was used for determination of chlorpheniramine (CPM), an antihistamine drug, in human urine samples using dispersive liquid-liquid microextraction (DLLME) followed by high performance liquid chromatography with diode array detection (HPLC-DAD). In this extraction technique, an appropriate mixture of acetonitrile (disperser solvent) and carbon tetrachloride (extraction solvent) was rapidly injected into the urine sample containing the target analyte. Tiny droplets of extractant were formed and dispersed into the sample solution and then sedimented at the bottom of the conical test tube by centrifugation. Under optimal conditions, the calibration curve was linear in the range of 0.055-5.5 µg mL-1, with a detection limit of 16.5 ng mL-1. This proposed method was successfully applied to the analysis of real urine samples. Low consumption of toxic organic solvents, simplicity of operation, low cost and acceptable figures of merit are the main advantages of the proposed technique.

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