Multidrug resistant Vibrio cholerae O1 El Tor carrying classical ctxB allele involved in a cholera outbreak in South Western India

Acta Tropica ◽  
2011 ◽  
Vol 117 (2) ◽  
pp. 152-156 ◽  
Author(s):  
M. Jain ◽  
A.K. Goel ◽  
P. Bhattacharya ◽  
M. Ghatole ◽  
D.V. Kamboj
Keyword(s):  
Vibrio Cholerae ◽  
Multidrug Resistant ◽  
Western India ◽  
Cholera Outbreak ◽  
Vibrio Cholerae O1 ◽  
El Tor

scholarly journals Emergence of Multidrug-Resistant Vibrio cholerae O1 Biotype El Tor in Port Blair, India

2012 ◽  
Vol 86 (6) ◽  
pp. 1015-1017 ◽  
Author(s):  
Debdutta Bhattacharya ◽  
D. S. Sayi ◽  
Haimanti Bhattacharjee ◽  
R. Thamizhmani ◽  
A. P. Bharadwaj ◽  
...  
Keyword(s):  
Vibrio Cholerae ◽  
Multidrug Resistant ◽  
Vibrio Cholerae O1 ◽  
El Tor

scholarly journals Origin and Dissemination of Altered El Tor Vibrio cholerae O1 Causing Cholera in Odisha, India: Two and Half Decade’s View

2021 ◽  
Vol 12 ◽  
Author(s):  
Bibhuti Bhusan Pal ◽  
Dipti Ranjan Behera ◽  
Smruti Ranjan Nayak ◽  
Ashish Kumar Nayak
Keyword(s):  
Vibrio Cholerae ◽  
Clonal Evolution ◽  
Coastal Region ◽  
Multidrug Resistant ◽  
Pulse Field ◽  
Asian Countries ◽  
Pulse Field Gel Electrophoresis ◽  
Vibrio Cholerae O1 ◽  
El Tor ◽  
Tribal Areas

The origin, spread and molecular epidemiology of altered El Tor Vibrio cholerae O1 strains isolated from cholera outbreaks/surveillance studies between 1995 and 2019 from different district of Odisha were analyzed. The stock cultures of V. cholerae O1 strains from 1995 to 2019 were analyzed through molecular analysis using different PCR assays and pulse field gel electrophoresis (PFGE) analysis. The spread map (month, year and place) was constructed to locate the dissemination of altered El Tor variants of V. cholerae O1 in this region. A total of 13 cholera outbreaks were caused by V. cholerae O1 Ogawa biotype El Tor carrying ctxB1 and ctxB7 genotypes. The ctxB1 alleles of V. cholerae O1 mostly confined to the coastal areas, whereas the ctxB7 genotypes, though originating in the coastal region of Odisha, concentrated more in the tribal areas. The positive correlation between virulence-associated genes (VAGs) was found through Pearson’s correlation model, indicative of a stronger association between the VAGs. The clonal relationship through PFGE between ctxB1 and ctxB7 genotypes of V. cholerae O1 strains exhibited 80% similarity indicating single- or multi-clonal evolution. It is evident from this study that the spread of multidrug-resistant V. cholerae O1-altered El Tor was dominant over the prototype El Tor strains in this region. The origin of altered El Tor variants of V. cholerae O1 occurred in the East Coast of Odisha established that the origin of cholera happened in the Gangetic belts of Bay of Bengal where all new variants of V. cholerae O1 might have originated from the Asian countries.

Antibiotic Resistance Conferred by a Conjugative Plasmid and a Class I Integron in Vibrio cholerae O1 El Tor Strains Isolated in Albania and Italy

1999 ◽  
Vol 43 (3) ◽  
pp. 693-696 ◽  
Author(s):  
Vincenzo Falbo ◽  
Alessandra Carattoli ◽  
Fabio Tosini ◽  
Cristina Pezzella ◽  
Anna Maria Dionisi ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Vibrio Cholerae ◽  
Molecular Basis ◽  
Gene Cassette ◽  
Multidrug Resistant ◽  
Conjugative Plasmid ◽  
Class 1 Integron ◽  
Class 1 ◽  
Vibrio Cholerae O1 ◽  
El Tor

ABSTRACT Multidrug-resistant Vibrio cholerae O1 El Tor strains isolated during the 1994 outbreak of cholera in Albania and Italy were characterized for the molecular basis of antibiotic resistance. All strains were found to be resistant to tetracycline, streptomycin, spectinomycin, trimethoprim, sulfathiazole, and the vibriostatic compound O/129 (2,4-diamino-6,7-diisopropylteridine). Resistance genes were self-transferable by a conjugative plasmid of about 60 MDa, with the exception of spectinomycin resistance, which was conferred by theaadA1 gene cassette located in the bacterial chromosome within a class 1 integron. The resistance to trimethoprim and O/129 was conferred by the dfrA1 gene, which was present on the plasmid. Although the dfrA1 gene is known to be borne on an integron cassette, class 1, 2, or 3 intI genes were not detected as part of the plasmid DNA from the strains studied.

scholarly journals Molecular characterization reveals involvement of altered el tor biotype Vibrio cholerae O1 strains in cholera outbreak at Hyderabad, India

2011 ◽  
Vol 49 (2) ◽  
pp. 280-284 ◽  
Author(s):  
Ajay Kumar Goel ◽  
Meenu Jain ◽  
Pramod Kumar ◽  
Pennagaram Sarguna ◽  
Meera Bai ◽  
...  
Keyword(s):  
Vibrio Cholerae ◽  
Molecular Characterization ◽  
Cholera Outbreak ◽  
Vibrio Cholerae O1 ◽  
El Tor

Vibrio cholerae O1 Ogawa El Tor strains with the ctxB7 allele driving cholera outbreaks in south-western India in 2012

2014 ◽  
Vol 25 ◽  
pp. 93-96 ◽  
Author(s):  
P. Kumar ◽  
D.K. Mishra ◽  
D.G. Deshmukh ◽  
M. Jain ◽  
A.M. Zade ◽  
...  
Keyword(s):  
Vibrio Cholerae ◽  
Western India ◽  
Vibrio Cholerae O1 ◽  
El Tor

Antibiotic Susceptibility Profile of ‘Vibrio Cholerae O1 Biotype El Tor Serotype Ogawa’ Outbreak in North Delhi, India

2018 ◽  
Vol 13 (04) ◽  
pp. 277-282
Author(s):  
Pragnya Jena ◽  
Abha Sharma ◽  
Shalini Duggal ◽  
Tanisha Bharara ◽  
Renu Gur
Keyword(s):  
Vibrio Cholerae ◽  
World Health ◽  
Resistance Pattern ◽  
Public Health Issue ◽  
Cholera Outbreak ◽  
Improved Sanitation ◽  
Vibrio Cholerae O1 ◽  
Stool Samples ◽  
Health Organization ◽  
El Tor

Background Cholera remains a public health issue, especially in developing countries. We report a cholera outbreak in North Delhi. Objective To report the causative agent of outbreak and to characterize, biotype, and analyze antimicrobial resistance pattern of V. cholerae isolated from cholera patients admitted to our hospital. The outbreak occurred from July 2016 to August 2016. Materials and Methods A total of 179 stool samples from pediatrics department were received and processed according to the current Clinical and Laboratory Standards Institute (CLSI) guidelines. Results Out of 179 stool samples received by the laboratory, 26 samples grew Vibrio cholerae O1 Biotype El Tor. Cefotaxime and ceftriaxone were the most sensitive drugs. All isolates were resistant to cotrimoxazole followed by tetracycline. Conclusion According to the World Health Organization (WHO), cholera is becoming endemic in Delhi. Emergence of multiple antibiotic-resistant cholera isolates is a concern. Prompt identification and notification of cholera are the key measures to avert cholera outbreak. Clean water supply and improved sanitation measures should be taken for prevention of cholera.

scholarly journals An outbreak of diarrhoeal disease of El Tor Vibrio cholerae O1 Ogawa in and around Yavatmal district, Maharashtra, India in 2018

2020 ◽  
Vol 7 (4) ◽  
pp. 1297
Author(s):  
Swati S. Kale ◽  
Pragati A. Bulle ◽  
Durgesh G. Deshmukh ◽  
Supriya S. Tankhiwale ◽  
Vivek M. Gujar
Keyword(s):  
Vibrio Cholerae ◽  
Diarrhoeal Disease ◽  
Cholera Outbreak ◽  
Vibrio Cholerae O1 ◽  
Stool Samples ◽  
El Tor

Background: Epidemics of cholera have been reported from various parts of India. We investigated the epidemic of cholera that occurred in and around Yavatmal district in Maharashtra, India 2018, reported during March to July.Methods: 711 stool samples collected from diarrhea patients were bacteriologically analyzed for their identification and antibiogram of Vibrio cholera.Results: The cholera outbreak was caused by V. cholerae O1 Ogawa biotype El Tor. All the V. cholerae isolates from the stool samples were sensitive to tetracycline, doxycycline, ofloxacin, ciprofloxacin gentamycin, cotrimoxazole and resistant to ampicillin and ceftazidime.Conclusions: The present outbreak was due to V. cholerae O1 Ogawa El Tor which seems to have completely replaced O139 serogroup of the previous outbreaks during the last decade.

scholarly journals A Cholera Outbreak of the Vibrio cholerae O1 El Tor Variant Carrying Classical CtxB in Northeastern Thailand in 2007

2010 ◽  
Vol 82 (5) ◽  
pp. 875-878 ◽  
Author(s):  
Kazuhisa Okada ◽  
Siriporn Chantaroj ◽  
Pathom Sawanpanyalert ◽  
Shigeyuki Hamada ◽  
Amonrattana Roobthaisong
Keyword(s):  
Vibrio Cholerae ◽  
Cholera Outbreak ◽  
Vibrio Cholerae O1 ◽  
El Tor ◽  
Northeastern Thailand
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