4-nitrobenzoylcoumarin potentiates the antiparasitic, anti-inflammatory and cardioprotective effects of benznidazole in a murine model of acute Trypanosoma cruzi infection

Acta Tropica ◽  
2022 ◽  
pp. 106314
Author(s):  
Diego F. Vilas-Boas ◽  
Raphaela R.G. Oliveira ◽  
Elda Gonçalves-Santos ◽  
Luana S. Silva ◽  
Lívia F. Diniz ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Murine Model ◽  
Cardioprotective Effects ◽  
Anti Inflammatory ◽  
Cruzi Infection

Induction of B- and T-cell responses to cruzipain in the murine model of Trypanosoma cruzi infection

2002 ◽  
Vol 4 (8) ◽  
pp. 805-813 ◽  
Author(s):  
Anita R. Schnapp ◽  
Christopher S. Eickhoff ◽  
Julio Scharfstein ◽  
Daniel F. Hoft
Keyword(s):  
T Cell ◽  
Trypanosoma Cruzi ◽  
Murine Model ◽  
T Cell Responses ◽  
Cell Responses ◽  
Cruzi Infection

Applicability of the use of charcoal for the evaluation of intestinal motility in a murine model of Trypanosoma cruzi infection

2007 ◽  
Vol 102 (4) ◽  
pp. 747-750 ◽  
Author(s):  
Gabriel Melo de Oliveira ◽  
Monica de Melo Medeiros ◽  
Wanderson da Silva Batista ◽  
Renata Santana ◽  
Tania C. Araújo-Jorge ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Murine Model ◽  
Intestinal Motility ◽  
Cruzi Infection

scholarly journals Acute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parameters

2012 ◽  
Vol 107 (2) ◽  
pp. 211-216 ◽  
Author(s):  
Diana Rodrigues da Silva ◽  
Solange Lisboa de Castro ◽  
Monique Castro da Silva Alves ◽  
Wanderson da Silva Batista ◽  
Gabriel Melo de Oliveira
Keyword(s):  
Trypanosoma Cruzi ◽  
Murine Model ◽  
Non Invasive ◽  
Cruzi Infection ◽  
Disease Parameters

scholarly journals Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection

2020 ◽  
Vol 115 ◽  
Author(s):  
Cynthia M Cascabulho ◽  
Marcelo Meuser-Batista ◽  
Kelly Cristina G de Moura ◽  
Maria do Carmo Pinto ◽  
Thabata Lopes Alberto Duque ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Anti Inflammatory ◽  
Cruzi Infection

scholarly journals Prevention of electrocardiographic and histopathologic alterations in the murine model of Chagas' disease by preinoculation of an attenuated Trypanosoma cruzi strain

1989 ◽  
Vol 31 (4) ◽  
pp. 248-255 ◽  
Author(s):  
Carlos Alberto Cuneo ◽  
Emma Molina de Raspi ◽  
Miguel Angel Basombrio
Keyword(s):  
Trypanosoma Cruzi ◽  
Supraventricular Tachycardia ◽  
Chagas Disease ◽  
Atrioventricular Block ◽  
Murine Model ◽  
Sinus Bradycardia ◽  
Pathogenic Strain ◽  
St Elevation ◽  
Group 3 ◽  
Cruzi Infection

The effects of infection with Trypanosoma cruzi on the electrocardiographic tracings of mice were studied in 4.groups of animals: (1) normal; (2) infected with a pathogenic T. cruzi strain (TS COB); (3) immunized with 3 intraperitoneal inocula of 10(6) attenuated T. cruzi epimastigotes (TCC) and (4) immunized-infected, which sequentially received the treatments of groups 3 and 2. Infection and protection were confirmed by xenodiagnosis and histopathology. Isolated alterations such as extrasystolia, 1st degree atrioventricular block, arrhythmia and ST elevation were observed in normal as well as infected mice. However, tracings taken repeatedly on each mouse over a 293 day period revealed a set of alterations which were more frequently seen in infected (14/22) than in normal (4/27) animals (p = 0.00048). These alterations consisted of supraventricular tachycardia, sinus bradycardia and persisting, first degree AV blocks, often associated to pacemaker changes. Inoculation of attenuated T. cruzi (group 3) did not increase these alterations (2/27 mice) but significantly prevented their development after challenge with the pathogenic strain (1/19 versus 14/22 mice, p = 0.000095). Thus, preimmunization reduced not only parasitemia but also a pathogenic consequence of T. cruzi infection. This evidence is relevant for immunoprevention studies against Chagas' disease.

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