scholarly journals Left ventricular dysfunction in asymptomatic patients with systemic lupus erythematosus

2011 ◽  
Vol 104 (4) ◽  
pp. 276 ◽  
Author(s):  
T. Filali ◽  
M. Gzara ◽  
F. Ajili ◽  
D. Lahidheb ◽  
M. Gommidh ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Left Ventricular Dysfunction ◽  
Lupus Erythematosus ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
Systemic Lupus ◽  
Asymptomatic Patients

Speckle tracking echocardiography for the evaluation of left ventricular function in children with systemic lupus erythematosus

Lupus ◽  
2020 ◽  
Vol 29 (11) ◽  
pp. 1449-1455
Author(s):  
Mai Emara ◽  
Maher Abdel Hafez ◽  
Aml El-Bendary ◽  
Osama El Razaky
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Natriuretic Peptide ◽  
Left Ventricular Dysfunction ◽  
Lupus Erythematosus ◽  
Speckle Tracking ◽  
Ventricular Dysfunction ◽  
Speckle Tracking Echocardiography ◽  
Left Ventricular ◽  
Systemic Lupus

Background Many studies in adult patients with systemic lupus erythematosus (SLE) have demonstrated that myocardial dysfunction was significantly associated with enhanced disease activity. However, similar studies in paediatric patients with SLE are limited. The aim of this study was to evaluate the role of speckle tracking echocardiography (STE) to detect left ventricular dysfunction in children with active and inactive SLE. Methods This prospective case–control study was carried out on 50 children with SLE. Thirty healthy age- and sex-matched children comprised the control group. The patients were further subdivided into two subgroups: active SLE and inactive SLE. Laboratory investigations undertaken included complete blood count, renal function, C3, C4, ANA, anti-dsDNA and serum N-terminal pro-B type natriuretic peptide. Echocardiographic examinations were performed on all children and included conventional echocardiography, tissue Doppler imaging (TDI) and two- and three-dimensional STE. Results There was no statistically significant difference in N-terminal pro B natriuretic peptide between the studied groups. The myocardial performance index by TDI was statistically significantly higher in SLE patients compared to controls. STE parameters were statistically significantly lower in SLE patients compared to controls. There was no correlation between STE parameters and disease activity. Conclusions STE could be a promising technique in the early detection of subclinical left ventricular dysfunction in children with SLE.

Systemic Lupus Erythematosus Cardiomyopathy-A Case Series Demonstrating a Reversible Form of Left Ventricular Dysfunction

2013 ◽  
Vol 31 (5) ◽  
pp. 563-568 ◽  
Author(s):  
Mariko L. Ishimori ◽  
Megha Agarwal ◽  
Roy Beigel ◽  
Rita K. Ng ◽  
Nazanin Firooz ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Left Ventricular Dysfunction ◽  
Lupus Erythematosus ◽  
Ventricular Dysfunction ◽  
Case Series ◽  
Left Ventricular ◽  
Systemic Lupus

scholarly journals Optical Coherence Tomography Angiography as a New Tool for Evaluation of the Subclinical Retinal Involvement in Patients with Systemic Lupus Erythematosus—A Review

2021 ◽  
Vol 10 (13) ◽  
pp. 2887
Author(s):  
Małgorzata Mimier-Janczak ◽  
Dorota Kaczmarek ◽  
Dawid Janczak ◽  
Radosław Kaczmarek
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Optical Coherence Tomography ◽  
Lupus Erythematosus ◽  
Optical Coherence Tomography Angiography ◽  
Diagnostic Process ◽  
Optical Coherence ◽  
Systemic Lupus ◽  
Asymptomatic Patients ◽  
Pubmed Database ◽  
Lupus Retinopathy

Knowing the proven relationship between lupus retinopathy and systemic changes and disease activity, it is crucial to find the possibility of early diagnosis of retinal changes at a subclinical level in order to provide faster medical intervention and protect the patient from irreversible changes in the eye and other organs. The aim of this review is an analysis of studies investigating early pathological changes in retinal vascularization obtained by optical coherence tomography angiography (OCTA) and their relationship to the systemic lupus erythematosus (SLE). A literature search was performed to identify all relevant articles, regarding detection of subclinical retinal changes using OCTA in systemic lupus erythematosus listed in PubMed database. Seven out of seven papers found showed a decrease in superficial capillary plexus in ocular asymptomatic patients diagnosed with SLE. A decrease in retinal vessel density measured by OCTA may be a good marker of SLE activity and poor prognosis. OCTA in a safe manner can give clinicians a new perspective on processes of vessel remodeling and answer the question of how SLE might impact the eye from a structural point of view. Adding OCTA to the standard diagnostic process of SLE patients, may detect systemic changes early and prevent further visual deterioration by stopping progression of lupus retinopathy.

scholarly journals Involvement of the wrist and hand joints and tendons in an Egyptian systemic lupus erythematosus cohort

2020 ◽  
Vol 47 (1) ◽  
Author(s):  
Omneya Mohamed-Ayman Abdel-Moniem ◽  
Sherine El-Sherif ◽  
Mohamed Sami Barakat ◽  
Diaa Fahmy Mohasseb ◽  
Yousra Hisham Abdel-Fattah
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Negative Correlation ◽  
Lupus Erythematosus ◽  
Power Doppler ◽  
Pinch Strength ◽  
Systemic Lupus ◽  
Hand Grip ◽  
Asymptomatic Patients ◽  
Subclinical Synovitis

Abstract Background Systemic lupus erythematosus (SLE) patients often suffer hand function limitations even in the absence of symptoms related to joint or tendon disorders. Recent researches reported the presence of ultrasonographic (US) subclinical synovitis and tendon involvement in asymptomatic patients. We aimed to assess US patterns in SLE patients and determine their relationship with clinical assessment, disease activity and hand functional status using handheld dynamometry. Results We assessed 30 SLE patients (60 hands) using US; 21 (70%) patient had synovial hypertrophy, 8 (26%) showed a power Doppler (PD) activity, 6 (20%) had erosions and 11 (36.6%) had tendon US abnormality. Both patients with hand arthralgia/arthritis (symptomatic) and patients without arthralgia/arthritis (asymptomatic) had a statistically insignificant difference regarding the global synovitis score (p = 0.2) and disease activity (p = 0.3). However, the symptomatic group had a significantly increased number of joints with effusion (p = 0.04) and tendons involved (p = 0.04). The mean grip strength had a significant negative correlation with SLEDAI-2 K score (rs = − 0.4, p = 0.02) in the total patient group. In the asymptomatic group, a negative correlation was found between both mean grip (rs = − 0.5, p = 0.04) and pinch strength (rs = − 0.6, p = 0.01) with PD index, and mean pinch strength with the Jaccoud’s arthropathy index (rs = − 0.49, p = 0.05). Conclusions SLE patients may have higher subclinical synovitis, erosions and tendon involvement than expected, which may in turn reduce hand grip and pinch strength. Disease activity may also have a negative impact on the hand grip functional strength.

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