scholarly journals Therapeutic management of malignant hypertension: Proof of concept of an entirely oral therapeutic approach

2021 ◽  
Vol 13 (1) ◽  
pp. 104-105
Author(s):  
R. Boulestreau ◽  
C. Brockers ◽  
S. Rubin ◽  
J. Doublet ◽  
J. Halimi ◽  
...  
Keyword(s):  
Therapeutic Approach ◽  
Malignant Hypertension ◽  
Therapeutic Management ◽  
Proof Of Concept ◽  
Oral Therapeutic

Topical and oral therapeutic approach to rosacea

2016 ◽  
Vol 35 (2) ◽  
pp. 74-78 ◽  
Author(s):  
Yolanda Helfrich ◽  
Lisa Maier
Keyword(s):  
Therapeutic Approach ◽  
Oral Therapeutic

scholarly journals Proteoglycans as Target for an Innovative Therapeutic Approach in Chondrosarcoma: Preclinical Proof of Concept

2016 ◽  
Vol 15 (11) ◽  
pp. 2575-2585 ◽  
Author(s):  
Caroline Peyrode ◽  
Valérie Weber ◽  
Aurélien Voissière ◽  
Aurélie Maisonial-Besset ◽  
Aurélien Vidal ◽  
...  
Keyword(s):  
Therapeutic Approach ◽  
Proof Of Concept

scholarly journals Therapeutic approach of human peritoneal carcinomatosis with Dbait in combination with capnoperitoneum: proof of concept

2011 ◽  
Vol 26 (3) ◽  
pp. 847-852 ◽  
Author(s):  
Wiebke Solass ◽  
Aurélie Herbette ◽  
Tina Schwarz ◽  
Alexander Hetzel ◽  
Jian-Sheng Sun ◽  
...  
Keyword(s):  
Peritoneal Carcinomatosis ◽  
Therapeutic Approach ◽  
Proof Of Concept

scholarly journals Has the Data Efflux Regarding the Promising Outcome Following Injection of Deflux Changed the Management of Adult Vesicoureteral Reflux?

2008 ◽  
Vol 2008 ◽  
pp. 1-5 ◽  
Author(s):  
D. E. Zilberman ◽  
Y. Mor
Keyword(s):  
Minimally Invasive ◽  
Vesicoureteral Reflux ◽  
Therapeutic Approach ◽  
Pediatric Population ◽  
Invasive Procedure ◽  
Therapeutic Management ◽  
Conservative Approach ◽  
Minimally Invasive Procedure ◽  
Therapeutic Approaches ◽  
Primary Vesicoureteral Reflux

Primary vesicoureteral reflux (VUR), traditionally considered a problem of childhood, can also be detected during adulthood. However, while the concept regarding the therapeutic management of VUR in children has undergone revolutionary changes, moving from surgical to conservative approach, the optimal therapeutic approach in adult reflux is poorly addressed and is still unknown. Herein, we review clinical and therapeutic approaches of VUR in pediatric population as published throughout the years. With the introduction of Deflux injection as a minimally invasive procedure, we identify a beginning of a new trend that further extends the indications for endoscopic injections, including its introduction to adult patients as well.

scholarly journals Magnetic ligand fishing using immobilized DPP-IV for identification of antidiabetic ligands in lingonberry extract

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0247329
Author(s):  
Rita de Cássia Lemos Lima ◽  
Ulrike Böcker ◽  
Gordon J. McDougall ◽  
J. William Allwood ◽  
Nils Kristian Afseth ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Catalytic Activity ◽  
Inhibitory Activity ◽  
Therapeutic Approach ◽  
Magnetic Beads ◽  
Proof Of Concept ◽  
Fruit Extract ◽  
Dpp Iv ◽  
Ligand Fishing

In this work, a new magnetic ligand fishing probe for discovery of DPP-IV inhibitory ligands was developed and it was tested as a proof of concept on the fruit extract of Vaccinium vitis-idaea (lingonberry). The ligands were shown to have appreciable dipeptidyl peptidase IV (DPP-IV) inhibitory activity (IC50: 31.8 μg mL-1).) Inhibition of DPP-IV is a well-known therapeutic approach for management of type 2 diabetes (T2D). DPP-IV was successfully immobilized onto magnetic beads and was shown to retain its catalytic activity and selectivity over a model mixture. A total of four ligands were successfully fished out and identified as cyanidin-3-galactoside (2), cyanidin-3-arabinoside (3), proanthocynidin A (4), and 10-carboxyl-pyranopeonidin 3-O-(6″-O-p-coumaroyl)-glucoside (5) using HPLC/HRMS.

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