scholarly journals A New Imaging Marker to Predict Incident Heart Failure: Annual Change in Left Atrioventricular Coupling Index. A cardiovascular MRI report from the Multi-Ethnic Study of Atherosclerosis (MESA)

2022 ◽  
Vol 14 (1) ◽  
pp. 28-29
Author(s):  
T. Pezel ◽  
B.A. Venkatesh ◽  
Y. Kato ◽  
H. De Vasconcellos ◽  
S.R. Heckbert ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiovascular Mri ◽  
Annual Change ◽  
Ethnic Study ◽  
Coupling Index ◽  
Incident Heart Failure

scholarly journals Left atrioventricular coupling index to predict incident heart failure: The Multi-Ethnic Study of Atherosclerosis (MESA)

2021 ◽  
Vol 13 (3) ◽  
pp. 239
Author(s):  
T. Pezel ◽  
B. Ambale Venkatesh ◽  
Y. Kato ◽  
H.D. De Vasconcellos ◽  
S.R. Heckbert ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ethnic Study ◽  
Coupling Index ◽  
Incident Heart Failure

scholarly journals Incident heart failure prediction: left atrioventricular functional coupling index (LAFCI) from the multi-ethnic study of atherosclerosis (MESA)

2021 ◽  
Vol 13 (1) ◽  
pp. 36-37
Author(s):  
T. Pezel ◽  
B. Ambale Venkatesh ◽  
H.D. De Vasconcellos ◽  
Y. Kato ◽  
M. Shabani ◽  
...  
Keyword(s):  
Heart Failure ◽  
Failure Prediction ◽  
Functional Coupling ◽  
Ethnic Study ◽  
Coupling Index ◽  
Incident Heart Failure

scholarly journals PROGRESSION OF VALVULAR CALCIFICATION IS ASSOCIATED WITH 10-YEAR CHANGE IN LEFT VENTRICULAR STRUCTURE AND INCIDENT HEART FAILURE: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS

2020 ◽  
Vol 75 (11) ◽  
pp. 874
Author(s):  
Oluwaseun E. Fashanu ◽  
Sireesha Upadhrasta ◽  
Di Zhao ◽  
Matthew J. Budoff ◽  
Ambarish Pandey ◽  
...  
Keyword(s):  
Heart Failure ◽  
Left Ventricular ◽  
Left Ventricular Structure ◽  
Ethnic Study ◽  
Valvular Calcification ◽  
Ventricular Structure ◽  
Incident Heart Failure

scholarly journals Serum Bicarbonate Is Associated with Heart Failure in the Multi-Ethnic Study of Atherosclerosis

2016 ◽  
Vol 45 (2) ◽  
pp. 118-126 ◽  
Author(s):  
Jessica B. Kendrick ◽  
Leila Zelnick ◽  
Michel B. Chonchol ◽  
David Siscovick ◽  
Andrew N. Hoofnagle ◽  
...  
Keyword(s):  
Heart Failure ◽  
Left Ventricular ◽  
Serum Bicarbonate ◽  
Community Based ◽  
Baseline Serum ◽  
Ethnic Study ◽  
Adult Participants ◽  
Kidney Disease Progression ◽  
Incident Heart Failure ◽  
Subclinical Cvd

Background: Low serum bicarbonate concentrations are associated with mortality and kidney disease progression. Data regarding associations between bicarbonate and cardiovascular disease (CVD) are scarce. Methods: We performed a cohort study of 6,229 adult participants from the Multi-Ethnic Study of Atherosclerosis, a community-based cohort free of CVD at baseline. Serum bicarbonate was measured at baseline. Cardiovascular outcomes were defined as: (1) subclinical CVD (left ventricular mass [LVM] and aortic pulse pressure [PP] measured at baseline), (2) incident atherosclerotic cardiovascular events (CVE; composite of myocardial infarction, resuscitated cardiac arrest, stroke, coronary heart disease death, and stroke death), and (3) incident heart failure. Results: During a median (interquartile range) follow-up of 8.5 (7.7-8.6) years, 331 (5.3%) participants had an incident CVE and 174 (2.8%) developed incident heart failure. We stratified analyses by use of diuretics because we observed a significant interaction between diuretic use and bicarbonate with study outcomes. Among diuretic nonusers, with adjustment, bicarbonate ≥25 mEq/L was associated with an estimated 3.0 g greater LVM (95% CI 0.5-5.0) and 1.0 mm Hg higher aortic PP (95% CI 0.4-2.0) compared to bicarbonate 23-24 mEq/L. Each 1 mEq/L of bicarbonate increase was associated with a 13% higher risk of incident heart failure (hazards ratio 1.13, 95% CI 1.01-2.11). Among diuretic users, higher bicarbonate was not associated with CVD. Bicarbonate was not associated with incident atherosclerotic CVE irrespective of diuretic use. Conclusion: Among nonusers of diuretics in a large community-based study, higher serum bicarbonate concentrations are associated with subclinical CVD and new heart failure.

scholarly journals Left ventricular area on non-contrast cardiac computed tomography as a predictor of incident heart failure – The Multi-Ethnic Study of Atherosclerosis

2016 ◽  
Vol 10 (6) ◽  
pp. 500-506 ◽  
Author(s):  
Marcio Sommer Bittencourt ◽  
Ron Blankstein ◽  
Songshou Mao ◽  
Juan J. Rivera ◽  
Alain G. Bertoni ◽  
...  
Keyword(s):  
Heart Failure ◽  
Computed Tomography ◽  
Cardiac Computed Tomography ◽  
Left Ventricular ◽  
Ethnic Study ◽  
Incident Heart Failure

scholarly journals Progression of Coronary Artery Calcium and Incident Heart Failure: The Multi‐Ethnic Study of Atherosclerosis

2017 ◽  
Vol 6 (4) ◽  
Author(s):  
Hooman Bakhshi ◽  
Bharath Ambale‐Venkatesh ◽  
Xiaoying Yang ◽  
Mohammad R. Ostovaneh ◽  
Colin O. Wu ◽  
...  
Keyword(s):  
Heart Failure ◽  
Coronary Artery ◽  
Coronary Artery Calcium ◽  
Ethnic Study ◽  
Incident Heart Failure

scholarly journals The relationship between measures of obesity and incident heart failure: The multi-ethnic study of atherosclerosis

Obesity ◽  
2013 ◽  
Vol 21 (9) ◽  
pp. 1915-1922 ◽  
Author(s):  
Imo A. Ebong ◽  
David C. Goff ◽  
Carlos J. Rodriguez ◽  
Haiying Chen ◽  
David A. Bluemke ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ethnic Study ◽  
Incident Heart Failure ◽  
The Relationship

scholarly journals Left atrioventricular coupling index to predict incident heart failure: the multi-ethnic study of atherosclerosis (MESA)

2021 ◽  
Vol 22 (Supplement_2) ◽  
Author(s):  
T Pezel ◽  
B Ambale Venkatesh ◽  
Y Kato ◽  
H De Vasconcellos ◽  
S Heckbert ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Prognostic Value ◽  
Left Ventricular ◽  
Model Discrimination ◽  
Ethnic Study ◽  
Funding Sources ◽  
C Statistic ◽  
Coupling Index ◽  
Score Model

Abstract Funding Acknowledgements Type of funding sources: None. BACKGROUND Although left atrial (LA) and left ventricular (LV) structural and functional parameters have independent prognostic value as predictors of HF, the close physiological relationship between LA and LV suggest that the assessment of LA/LV coupling could better reflect left atrioventricular dysfunction and be a better predictor of heart failure (HF). PURPOSE We investigated the prognostic value of a left atrioventricular coupling index (LACI), measured by cardiovascular magnetic resonance (CMR), as well as change in LACI to predict incident HF in the Multi-Ethnic Study of Atherosclerosis (MESA). METHODS In the MESA, 2,250 study participants, free of clinically recognized HF and cardiovascular disease at baseline, had LACI assessed by CMR imaging at baseline (Exam 1, 2000–2002), and ten years later (Exam 5, 2010–2012). LACI was defined as the ratio of LA to LV end-diastolic volumes. Univariable and multivariable Cox proportional hazard models were used to evaluate the associations of LACI and average annualized change in LACI (ΔLACI) with incident HF after adjustment on traditional HF risk factors. The incremental risk prediction was calculated using C-statistic, categorical net reclassification index (NRI) and integrative discrimination index (IDI). RESULTS Among the 2,250 participants (mean age 59.3 ± 9.3 years and 47.6% male participants), 50 incident HF events occurred over 6.8 ± 1.3 years after the second CMR exam. After adjustment, greater LACI and ΔLACI were independently associated with HF (adjusted HR 1.44, 95% CI [1.25-1.66] and adjusted HR 1.55, 95% CI [1.30-1.85], respectively; both p < 0.0001). Adjusted models for LACI showed significant improvement in model discrimination and reclassification compared to currently used HF risk score model for predicting HF incidence (C-statistic: 0.81 vs. 0.77; NRI = 0.411; IDI = 0.043). After adjustment, ΔLACI showed also significant improvement in model discrimination compared to the multivariable model with traditional HF risk factors for predicting incident HF (C-statistic: 0.82 vs. 0.77; NRI = 0.491; IDI = 0.058). CONCLUSIONS In a multi-ethnic population, atrioventricular coupling (LACI) and coupling change (ΔLACI) are independently associated with incident HF. Both have incremental prognostic value for predicting HF over traditional HF risk factors.

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