Microsponge drug delivery system (MDDS) technology holds a remarkable promise for achieving the aim of controlled and site-specific drug delivery which reduce systemic exposure and minimize local cutaneous reactions to active drug and as a result, has attracted huge interest of researchers. Microsponges consist of microporus beads, typically 10-25 microns in diameter, loaded with active agent. When carried out to the skin, the microsponge releases its active element on a time mode and also in reaction to different stimuli (rubbing, temperature, pH, and many others) which can be used ordinarily for topical and lately for oral management. This article gives a extensive assessment of Microsponges drug transport system discussing the concepts and practise methods. Appropriate analytical techniques for characterization of microsponges like particle size and its distribution, surface morphology, porosity, density, In Vitro drug release studies as well as applications of microsponge and future prospects are covered. Advantages/Potential functions, limitations and their possible remedies of the microsponge and programmable parameters are also mentioned. The microsponge are used in the sunscreens, creams, ointments, over the counter skin care preparations, which are meant for topical application. microsponge drug delivery can provide increased efficacy for topical active agent with enhanced safety, extended product stability.
Exploring interactions between extracellular vesicles and cells for innovative drug delivery system design
