scholarly journals Microsponge Technology for Innovative Drug Delivery System

2020 ◽  
pp. 63-75
Author(s):  
Lendave A. S.
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Transport ◽  
Active Agent ◽  
Systemic Exposure ◽  
Analytical Techniques ◽  
Innovative Drug ◽  
Cutaneous Reactions

Microsponge drug delivery system (MDDS) technology holds a remarkable promise for achieving the aim of controlled and site-specific drug delivery which reduce systemic exposure and minimize local cutaneous reactions to active drug and as a result, has attracted huge interest of researchers. Microsponges consist of microporus beads, typically 10-25 microns in diameter, loaded with active agent. When carried out to the skin, the microsponge releases its active element on a time mode and also in reaction to different stimuli (rubbing, temperature, pH, and many others) which can be used ordinarily for topical and lately for oral management. This article gives a extensive assessment of Microsponges drug transport system discussing the concepts and practise methods. Appropriate analytical techniques for characterization of microsponges like particle size and its distribution, surface morphology, porosity, density, In Vitro drug release studies as well as applications of microsponge and future prospects are covered. Advantages/Potential functions, limitations and their possible remedies of the microsponge and programmable parameters are also mentioned. The microsponge are used in the sunscreens, creams, ointments, over the counter skin care preparations, which are meant for topical application. microsponge drug delivery can provide increased efficacy for topical active agent with enhanced safety, extended product stability.

A Review on Novel Drug Delivery System: Microsponges

2017 ◽  
Vol 7 (04) ◽  
Author(s):  
Soumya Singh ◽  
Dherendra Sahu
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery System ◽  
Delivery System ◽  
Active Ingredient ◽  
Suspension Polymerization ◽  
Rapid Evolution ◽  
Active Agent ◽  
Systemic Exposure ◽  
Emulsion System

Recent research on idealizing drug delivery system which is progressing at a prodigious rate and aims at development of drug delivery system (DDS), with maximum therapeutic advantages of drug delivery, thus resulting in safe and effective management of disease. More and more developments in delivery systems are being integrated to optimize the efficacy and cost effectiveness of the therapy. New classes of pharmaceuticals, biopharmaceuticals are fueling the rapid evolution of drug delivery technology. Microsponge technology has been introduced in topical drug products to facilitate the controlled release of active drug into the skin in order to reduce systemic exposure and minimize local cutaneous reactions to active drugs. Microsponge consists of microporous beads loaded with active agent. When applied to the skin, the microsponge releases its active ingredient on a time mode and also in response to other stimuli (rubbing, temperature, pH etc.) that are used mostly for topical and recently for oral administration Microsponges are porous, polymeric microspheres that are mostly used for prolonged topical administration. Microsponges are designed to deliver a pharmaceutically active ingredient efficiently at minimum dose and also to enhance stability, reduce side effects, and modify drug release profiles. Microsponges are prepared by several methods utilizing emulsion system or by suspension polymerization in a liquid–liquid system. The most common emulsion system used is oil-in-water (o/w), with the microsponges being produced by the emulsion solvent diffusion (ESD) method. Microsponge delivery system (MDS) can provide increased efficacy for topically active agents with enhanced safety, extended product stability, enhanced formulation flexibility, reduced side effects and improved aesthetic properties in an efficient and novel manner. In addition these are non-irritating, non-mutagenic, non-allergenic, and nontoxic. The present review introduces microsponge technology in great detail.

scholarly journals Formulation development of an albendazole self-emulsifying drug delivery system (SEDDS) with enhanced systemic exposure / Razvoj samoemulzifirajućeg sustava za isporuku albendazola (SEDDS) s pojačanom sistemskom apsorpcijom

2012 ◽  
Vol 62 (4) ◽  
pp. 563-580 ◽  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Systemic Exposure ◽  
Tween 80 ◽  
Water Soluble ◽  
Formulation Development ◽  
Suspension Formulation ◽  
Water Soluble Drugs

The aim of the study was to develop and evaluate a self- -emulsifying drug delivery system (SEDDS) formulation to improve solubility and dissolution and to enhance systemic exposure of a BCS class II anthelmetic drug, albendazole (ABZ). In the present study, solubility of ABZ was determined in various oils, surfactants and co-surfactants to identify the microemulsion components. Pseudoternary phase diagrams were plotted to identify the microemulsification existence area. SEDDS formulation of ABZ was prepared using oil (Labrafac Lipopfile WL1349) and a surfactant/ co-surfactant (Tween 80/PEG 400) mixture and was characterized by appropriate studies, viz., microemulsifying properties, droplet size measurement, in vitro dissolution, etc. Finally, PK of the ABZ SEDDS formulation was performed on rats in parallel with suspension formulation. It was concluded that the SEDDS formulation approach can be used to improve the dissolution and systemic exposure of poorly water-soluble drugs such as ABZ.

scholarly journals Development of Bioadhesive Chitosan Superporous Hydrogel Composite Particles Based Intestinal Drug Delivery System

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Hitesh Chavda ◽  
Ishan Modhia ◽  
Anant Mehta ◽  
Rupal Patel ◽  
Chhagan Patel
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Transport ◽  
Release Kinetics ◽  
Hydrogel Composite ◽  
Intestinal Delivery ◽  
Superporous Hydrogel

Bioadhesive superporous hydrogel composite (SPHC) particles were developed for an intestinal delivery of metoprolol succinate and characterized for density, porosity, swelling, morphology, and bioadhesion studies. Chitosan and HPMC were used as bioadhesive and release retardant polymers, respectively. A 32full factorial design was applied to optimize the concentration of chitosan and HPMC. The drug loaded bioadhesive SPHC particles were filled in capsule, and the capsule was coated with cellulose acetate phthalate and evaluated for drug content,in vitrodrug release, and stability studies. To ascertain the drug release kinetics, the drug release profiles were fitted for mathematical models. The prepared system remains bioadhesive up to eight hours in intestine and showed Hixson-Crowell release with anomalous nonfickian type of drug transport. The application of SPHC polymer particles as a biomaterial carrier opens a new insight into bioadhesive drug delivery system and could be a future platform for other molecules for intestinal delivery.

Preparation and analysis of human medication tablets in drug delivery system

2020 ◽  
Vol 10 (3) ◽  
pp. 59-62
Author(s):  
Soujanya H ◽  
Purushothaman M ◽  
Jagadeeshwari S ◽  
Shiva Kumar K
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Innovative Drug ◽  
Significant Deterioration ◽  
R And D ◽  
Assessment Tests ◽  
Medication Delivery ◽  
Set Up

Presently days, a significant objective medication conveyance study is twisted to the improvement of robust medication conveyance frameworks with previously existing dynamic fixings in the event of new medication disclosure. A considerable lot of remedial drug operators are generally viable when made accessible at steady rates close to assimilation locales. Much exertion has been proceeding to create advanced medication conveyance frameworks, for example, osmotic gadgets for oral request. Oral medication conveyance framework is more preferred on famous measured medication conveyance framework in innovative drug work (R and D) business because of increment in attention to clinical and drug network about the significance of sheltered and viable utilization of medication. In the current examination work, pulsatile drug conveyance arrangement of Zileuton tablets was planned by utilizing pressure covering innovation. At first, the centre tablets were set up by 30% groupings of wonderful crumbles; the figured centre tablets were covered with the polymers by utilizing pressure covering innovation. All the centre and press covered tablet details were exposed to different corporeal and concoction assessment tests for centre and press covered tablets. The hardness, thickness and weight variety appeared by all the tablet definitions were originate inside the authorized pharmacopoeias bounds. In-vitro arrival of Zileuton of centre tablet details F1 demonstrated quicker medication discharge after 15 min. Quicker medication delivery can be connected with significant deterioration, and friability saw in this examination. The enteric covered plans C1, C3 indicated the most significant medication discharge following 4 hours. Time subordinate pulsatile drug conveyance framework has been accomplished from the tablet of definition C3, C6 and C9 with 95.5%, 94.76% and 97.48% separately.

scholarly journals Compartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery System

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1862
Author(s):  
Emily Dosmar ◽  
Gabrielle Vuotto ◽  
Xingqi Su ◽  
Emily Roberts ◽  
Abigail Lannoy ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Transport ◽  
3D Model ◽  
Release Behavior ◽  
Drug Diffusion ◽  
Release Drug ◽  
Antibiotic Drug

The purpose of this study was to examine antibiotic drug transport from a hydrogel drug delivery system (DDS) using a computational model and a 3D model of the eye. Hydrogel DDSs loaded with vancomycin (VAN) were synthesized and release behavior was characterized in vitro. Four different compartmental and four COMSOL models of the eye were developed to describe transport into the vitreous originating from a DDS placed topically, in the subconjunctiva, subretinally, and intravitreally. The concentration of the simulated DDS was assumed to be the initial concentration of the hydrogel DDS. The simulation was executed over 1500 and 100 h for the compartmental and COMSOL models, respectively. Based on the MATLAB model, topical, subconjunctival, subretinal and vitreous administration took most (~500 h to least (0 h) amount of time to reach peak concentrations in the vitreous, respectively. All routes successfully achieved therapeutic levels of drug (0.007 mg/mL) in the vitreous. These models predict the relative build-up of drug in the vitreous following DDS administration in four different points of origin in the eye. Our model may eventually be used to explore the minimum loading dose of drug required in our DDS leading to reduced drug use and waste.

scholarly journals Acidic microenvironment responsive polymeric MOF-based nanoparticles induce immunogenic cell death for combined cancer therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Xiaoli Zhang ◽  
Yi Lu ◽  
Die Jia ◽  
Wei Qiu ◽  
Xianbin Ma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Death ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Therapy ◽  
Immunogenic Cell Death ◽  
Innovative Drug ◽  
Acidic Microenvironment

Abstract Background The complex tumor microenvironment and non-targeting drugs limit the efficacy of clinical tumor therapy. For ensuring the accurate delivery and maximal effects of anticancer drugs, it is important to develop innovative drug delivery system based on nano-strategies. Result In this study, an intracellular acidity-responsive polymeric metal organic framework nanoparticle (denoted as DIMP) has been constructed, which can co-deliver the chemotherapy agent of doxorubicin (DOX) and phototherapy agent of indocyanine green (ICG) for breast carcinoma theranostics. Specifically, DIMP possesses a suitable and stable nanometer size and can respond to the acidic microenvironment in cells, thus precisely delivering drugs into target tumor sites and igniting the biological reactions towards cell apoptosis. Following in vivo and in vitro results showed that DIMP could be effectively accumulated in tumor sites and induced powerful immunogenic cell death (ICD) effect. Conclusion The designed DIMP displayed its effectiveness in combined photo-chemotherapy with auxiliary of ICD effect under a multimodal imaging monitor. Thus, the present MOF-based strategy may offer a potential paradigm for designing drug-delivery system for image-guided synergistic tumor therapy. Graphical Abstract

scholarly journals FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF LAFUTIDINE

2018 ◽  
Vol 8 (5) ◽  
pp. 393-399
Author(s):  
Ramdas T. Dolas ◽  
Shalindra Sharma ◽  
Madhuraj Sharma
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Active Agent ◽  
Lag Time ◽  
In Vitro Dissolution ◽  
Wet Granulation ◽  
Floating Tablets

The purpose of this research was to develop a novel gastroretentive drug delivery system based on wet granulation technique for sustained delivery of active agent. Quick GI transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to decreased efficacy of the administered dose and thus less patient compliance. Gastroretentive floating tablets, which was designed to provide the desired sustained and complete release of drug for prolonged period of time. Gastroretentive floating tablets of lafutidine were prepared by wet granulation technique using different concentrations of Gum Kondagagu, Gum olibanum and Locust bean Gum. The optimized formulation (LF14) exhibited 99.54% drug release in 12 hrs, while the buoyancy lag time was 33 sec. In-vitro drug release kinetics was found to follow both the Zero order and the possible mechanism of lafutidine release from the optimized formulation might be attributed to super case II transport mechanism. The Optimized formulation (LF14) showed no significant change in physical appearance, drug content, floating lag time, in vitro dissolution studies after 75%±5% RH at 40±20C relative humidity for 6 months. Keyword: Wet granulation, Floating lag Time, Gastroretentive, Lafutidine

Wetting transition in nanochannels for biomimetic free-blocking on-demand drug transport

2018 ◽  
Vol 6 (39) ◽  
pp. 6269-6277 ◽  
Author(s):  
Yaya Cheng ◽  
Xiangyu Jiao ◽  
Liang Zhao ◽  
Yang Liu ◽  
Fang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Transport ◽  
Mesoporous Silica Nanoparticles ◽  
Wetting Transition ◽  
On Demand ◽  
Inner Surface

Inspired by aquaporins in nature, herein, a biomimetic free-blocking on-demand drug delivery system is proposed, which is constructed by controlling the wettability of the inner surface of nanochannels on mesoporous silica nanoparticles (MSNs).

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