Cutaneous Solitary Fibrous Tumor: A Spindle Cell Neoplasm With Distinctive Immunohistochemical Features

2018 ◽  
Vol 109 (2) ◽  
pp. 183-185
Author(s):  
J. Santos-Juanes ◽  
B. García-García ◽  
Y. Hidalgo ◽  
B. Vivanco
Keyword(s):  
Solitary Fibrous Tumor ◽  
Spindle Cell ◽  
Spindle Cell Neoplasm ◽  
Cell Neoplasm ◽  
Fibrous Tumor

Solitary Fibrous Tumor of the Kidney. A Propos of a Case

2009 ◽  
Vol 76 (2) ◽  
pp. 112-114 ◽  
Author(s):  
M. Marzi ◽  
M. D'Alpaos ◽  
P. Piras ◽  
A. Paiusco ◽  
M.S. Minervini ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Renal Pelvis ◽  
Spindle Cell ◽  
Left Kidney ◽  
Clinical Behavior ◽  
Spindle Cell Neoplasm ◽  
Solitary Fibrous Tumors ◽  
Genital Apparatus ◽  
Cell Neoplasm ◽  
Fibrous Tumor

Solitary Fibrous Tumors (SFT) are rare spindle cell neoplasm that typically originate from the pleura. However, cases of the SFT are described with origin in other organs, including the urinary and genital apparatus. Within the kidney, except from the renal pelvis, only 19 cases of SFT are described and such rarity of localization makes the histogenesis and the prognosis of the tumor rather unknown. We report the case of a 72-year-old lady who attended our Unit for a mass that was clinically palpable at the level of the left hemiabdomen. The tomodensitographic test indicated a 19cm-diameter mass of likely pertinence of the middle bystender of the left kidney. She had undergone left radical nephrectomy. The histological examination highlighted a solitary fibrous tumor (SFT): the presence of hypercellularity, of cellular pleiomorphism and of a high number of mitosis has led to a histological diagnosis of malignancy for the neoplasm analyzed. The SFT are of rare clinical comparison: this does not allow for a deep knowledge of the lesion histogenesis and prognosis; moreover, the clinical behavior should be more precisely defined.

scholarly journals Solitary Fibrous Tumor of the Kidney: A Case Report

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Abdullah Demirtaş ◽  
Volkan Sabur ◽  
Hülya Akgün ◽  
Emre Can Akınsal ◽  
Deniz Demirci
Keyword(s):  
Solitary Fibrous Tumor ◽  
Cystic Lesion ◽  
Spindle Cell ◽  
Left Kidney ◽  
Ki 67 ◽  
Spindle Cell Neoplasm ◽  
Cell Neoplasm ◽  
Fibrous Tumor ◽  
Immunohistochemical Studies ◽  
Hmb 45

Solitary fibrous tumor is a spindle cell neoplasm mostly originating from pleura; however, it has also recently been reported to be extrapleural. A 57-year-old man presented with left lumbal pain. Ultrasonography and computed tomography showed a cystic lesion of 14 × 11 cm with solid areas and septations in middle and lower poles of the left kidney. Radical nephrectomy was performed. Immunohistochemical studies showed strong reactions with CD34 and CD99. A nuclear positivity with Ki-67 was observed in less than 1% of cells. Despite repeated stainings with vimentin, no clear tumor evaluation could be made due to artifacts. The tumor was negative with Bcl-2, desmin, HMB-45, S100, FVIII, and CD31. Histopathological and molecular studies made the diagnosis of a solitary fibrous tumor. The patient is now currently free of disease at the 26th month of followup.

scholarly journals Solitary Fibrous Tumor of the Sigmoid Colon Masquerading as an Adnexal Neoplasm

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Laura Bratton ◽  
Rabih Salloum ◽  
Wenqing Cao ◽  
Aaron R. Huber
Keyword(s):  
Sigmoid Colon ◽  
Solitary Fibrous Tumor ◽  
High Power ◽  
Spindle Cell ◽  
Cytologic Atypia ◽  
Spindle Cell Neoplasm ◽  
Solitary Fibrous Tumors ◽  
Cell Neoplasm ◽  
Mitotic Figures ◽  
Fibrous Tumor

Solitary fibrous tumor is a rare, benign spindle cell neoplasm that was first described in the thoracic pleura. This tumor is now known to occur at many extrapleural sites. There are established criteria for the diagnosis of malignant solitary fibrous tumor including ≥4 mitotic figures per 10 high-power fields, increased cellularity, cytologic atypia, infiltrative margins, and/or necrosis. Although all solitary fibrous tumors have the potential to recur or metastasize, those with malignant histologic features tend to behave more aggressively. We report a case of solitary fibrous tumor, with malignant histologic features, in a 21-year-old woman which arose from the serosal surface of the sigmoid colon.

scholarly journals Solitary Fibrous Tumor of the Auditory Canal

2004 ◽  
Vol 128 (12) ◽  
pp. e169-e171 ◽  
Author(s):  
Sherif Rezk ◽  
Mohammad Yousef ◽  
Marshall Zamansky ◽  
Ashraf Khan
Keyword(s):  
Salivary Glands ◽  
Solitary Fibrous Tumor ◽  
Paranasal Sinuses ◽  
Spindle Cell ◽  
Immunohistochemical Analysis ◽  
Spindle Cell Neoplasm ◽  
Cell Neoplasm ◽  
Fibrous Tumor

Abstract Solitary fibrous tumor (SFT) is an uncommon spindle cell neoplasm of increasing incidence that was originally described to be of pleural origin; however, more recently, SFT has been reported in extrapleural sites, including the orbit, liver, salivary glands, tongue, nose, paranasal sinuses, larynx, retroperitoneum, meninges, and thyroid. The increase in the number of SFTs does not necessarily mean increased incidence of this tumor but rather an increased understanding of this tumor, especially recognition of this tumor in extrapleural locations, which has been aided by immunohistochemical analysis. We report a case of SFT in the auditory canal, which to our knowledge has not been previously reported, as evident by morphologic findings and immunophenotype.

scholarly journals Solitary Fibrous Tumor of the Kidney with Massive Retroperitoneal Recurrence. A Case Presentation

2012 ◽  
Vol 113 (3) ◽  
pp. 246-250 ◽  
Author(s):  
Stavros Sfoungaristos ◽  
M. Papatheodorou ◽  
A. Kavouras ◽  
P. Perimenis
Keyword(s):  
Solitary Fibrous Tumor ◽  
Tumor Recurrence ◽  
Spindle Cell ◽  
Surgical Excision ◽  
Imaging Findings ◽  
Case Presentation ◽  
Spindle Cell Neoplasm ◽  
Cell Neoplasm ◽  
Fibrous Tumor ◽  
Disease Free

Solitary fibrous tumor is an unusual spindle cell neoplasm that usually occurs in the pleura but has also been described in other sites. Renal presentation is rare and only 38 cases of SFT of the kidney have been described until now. Up to 90% of the tumors have benign characteristics. Local retroperitoneal recurrence is extremely rare. We report a case of a large malignant solitary fibrous tumor recurrence after the surgical excision of the primary tumor. Histological examination of the specimen confirmed the diagnosis by revealing highly positive reaction of the neoplasmatic cells for vimentin, CD34, bcl-2 and moderately positive for actin. The rate of Ki67 lied between 2–7%. No adjuvant therapy was given to the patient and he is disease-free with no imaging findings of recurrence or metastasis 9 months after the re-operation.

scholarly journals Intra-Abdominal Solitary Fibrous Tumor secretes high molecular weight IGF-II, causing Hypoglycemia

2020 ◽  
Vol 5 (5) ◽  
Keyword(s):  
Molecular Weight ◽  
Solitary Fibrous Tumor ◽  
Islet Cell ◽  
Spindle Cell ◽  
Islet Cell Tumor ◽  
Cell Tumor ◽  
Spindle Cell Neoplasm ◽  
Cell Neoplasm ◽  
Fibrous Tumor ◽  
Tumor Hypoglycemia

Hypoglycemia is a common event that has many well-known causes. Nevertheless, Non-islet cell tumor hypoglycemia (NICTH) is not one of them. As a matter of fact, NICTH is a rare but serious paraneoplastic syndrome. Solitary Fibrous tumor (SFT) is a rare spindle cell neoplasm derived from mesenchymal cells that in just 5% of cases releases “The Big” Insulin-like Growth Factor (IGF) II leading to hypoglycemic events [1].

scholarly journals Perbaikan Kualitas Hidup pada Pasien Solitary Fibrous Tumor Mediastinum: Perspektif Kemoterapi Paliatif

2020 ◽  
Vol 5 (2) ◽  
pp. 41
Author(s):  
Aryo Dirgantara Putra ◽  
Winarinani Koesoemoprodjo
Keyword(s):  
Tumor Cell ◽  
Solitary Fibrous Tumor ◽  
Immunohistochemical Staining ◽  
Spindle Cell ◽  
Cell Cytoplasm ◽  
Positive Tumor Cell ◽  
Spindle Cell Neoplasm ◽  
Cell Neoplasm ◽  
Negative Tumor ◽  
Fibrous Tumor

Background: Mediastinal solitary fibrous tumor (SFT) is a rare spindle cell neoplasm. Approximately 1 to 8% of these intrathoracic tumors have been reported to occur in the mediastinum. The chief complaints of mediastinal SFT are cough, shortness of breath or chest pain, or may occur as asymptomatic incidental mass. The treatment of choice for SFT is extensive surgical resection. However, when the tumor cannot be removed surgically or when metastases occur, chemotherapy and or radiotherapy can be proposed as palliative treatments. Case: A 19-year-old man with chief complaint of left chest pain and referred to his left back. The complaint is accompanied by cough without sputum and hoarseness. In thoracic CT scan with contrast, we found giant cystic mass suspect malignancy around 17x12x18 cm in left hemithorax, a minimal pericardial effusion, and left pleural effusion. There were positive tumor cell cytoplasm results in vimentin, negative tumor cell cytoplasm in CK, positive tumor cell membrane in CD99, cytoplasm of focal positive tumor cells in EMA, and negative tumor cells in CD34 which supported a solitary fibrous tumor in the immunohistochemical staining analysis. Doxorubicin-Ifosfamide regimen was the choice of chemotherapy palliative treatment in the case report. In the CT scan evaluation of thorax with contrast, we found stable disease (RECIST criteria) with improve quality of life (QOL) according to EQ-5D-3L, 11111 indicated no problems in 5 dimensions, such as mobility, self-care, usual activities, pain or discomfort, and anxiety or depression. Conclusion: Mediastinal SFT is a rare spindle cell neoplasm, and the diagnosis requires pathological and immunohistochemical staining analysis. Doxorubicin-Ifosfamide regimen can be proposed as a palliative chemotherapy regimen, which has been shown to improve QOL patients in Mediastinal SFT. EQ-5D is a simple tool that can be used to measure QOL such as mobility, self-care, usual activities, pain or discomfort, and anxiety or depression.

scholarly journals Malignant solitary fibrous tumor of the thyroid: a case-report and review of the literature

2014 ◽  
Vol 58 (4) ◽  
pp. 402-406 ◽  
Author(s):  
Wellington Alves Filho ◽  
Renata Regina da Graça Lorencetti Mahmoud ◽  
Daniel Marin Ramos ◽  
Vergilius José Furtado de Araujo-Filho ◽  
Patricia Picciarelli de Lima ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Solitary Fibrous Tumor ◽  
Spindle Cell ◽  
Spindle Cell Neoplasm ◽  
Cellular Atypia ◽  
Long Term Follow Up ◽  
History Of ◽  
Fibrous Tumor

Solitary fibrous tumor (SFT) is an uncommon spindle-cell neoplasm that most often involves the pleura, rarely occurring in extra-thoracic locations. Twenty-six cases of SFT arising in the thyroid gland have been described. We report a case of a 60-year-old woman presenting an 8-month history of enlargement of the neck associated with dysphagia. The patient underwent a right hemithyroidectomy and SFT of the thyroid was diagnosed. Immunohistochemistry showed positivity for CD34 marker, and the high number of mitoses and the presence of cellular atypia suggested that the tumor was malignant. To our knowledge, this is the second case of malignant SFT of the thyroid gland ever reported. Due to the rarity of these tumors, the indication of adjuvant therapy and prognosis are uncertain. Long-term follow-up after surgical resection seems to be advisable.

scholarly journals Solitary Fibrous Tumour of Cheek: A Diagnostic Dilemma

2020 ◽  
Vol 7 (6) ◽  
pp. C82-85
Author(s):  
Subhash Yadav ◽  
Shubhada Kane
Keyword(s):  
Spindle Cell ◽  
Mouth Opening ◽  
Young Male ◽  
Neck Region ◽  
Diagnostic Dilemma ◽  
Spindle Cell Neoplasm ◽  
Cell Neoplasm ◽  
Diagnostic Difficulties ◽  
Fibrous Tumor ◽  
Head Neck

Solitary fibrous tumor (SFT), an uncommon spindle cell neoplasm is believed to be of mesenchymal origin and usually presents as pleural based mass. SFT are rare in the head-neck region but are extremely uncommon intra-orally. The patient was a young male who presented with difficulty in mouth opening. Examination revealed a submucosal nodule on the buccal surface which was histologically and immunohistochemically proven to be SFT. Authors wish to discuss the case due to its rarity and diagnostic difficulties due to many common histological mimickers at that site.

Fibromyxomatous spindle cell neoplasm of the ethmoid sinus with extension into the optic cavity: Report of a case and review of the literature

2010 ◽  
Vol 120 (S3) ◽  
pp. S119-S119
Author(s):  
Joshua M Levy ◽  
Christian P Hasney ◽  
Paul L Friedlander ◽  
Michael S Ellis ◽  
Mary A Fazekas-May
Keyword(s):  
Spindle Cell ◽  
Ethmoid Sinus ◽  
Review Of The Literature ◽  
Spindle Cell Neoplasm ◽  
Cell Neoplasm
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