Effects of potassium supplementation on the recovery of thyrotoxic periodic paralysis

2004 ◽  
Vol 22 (7) ◽  
pp. 544-547 ◽  
Author(s):  
Kuo-Cheng Lu ◽  
Yu-Juei Hsu ◽  
Jainn-Shiun Chiu ◽  
Yaw-Don Hsu ◽  
Shih-Hua Lin
2016 ◽  
Vol 15 (4) ◽  
pp. 209-211
Author(s):  
Suzanne R Harrogate ◽  
◽  
Edouard Mills ◽  
Asjid Qureshi ◽  
Jacob F de Wolff ◽  
...  

A previously healthy 35-year old man presented to hospital with acute leg weakness following an alcohol binge. On assessment, tachycardia, urinary retention and bilateral upper and lower limb proximal weakness with preserved peripheral power were noted. Biochemistry revealed marked hypokalaemia, which responded to intravenous replacement, and biochemical thyrotoxicosis, leading to the diagnosis of Thyrotoxic Periodic Paralysis (TPP). Anti-thyroid therapy and beta-blockers were commenced and his neurological symptomatology resolved as he became progressively euthyroid. TPP is a rare acquired subtype of hypokalaemic periodic paralysis, typically causing proximal muscle weakness associated with thyrotoxicosis. It is most common in young Asian males. Acute treatment requires cautious oral potassium supplementation, beta-blockade, and anti-thyroid therapy. TPP is prevented by maintaining euthyroidism; otherwise recurrence is likely.


2021 ◽  
Vol 16 (2) ◽  
pp. 49-54
Author(s):  
Shirley Shuster ◽  
Caitlyn Vlasschaert ◽  
Sara Awad

Thyrotoxic periodic paralysis (TPP) is characterized by muscle weakness, areflexia, and hypokalemia in the setting of thyrotoxicosis. We present the case of a 32-year-old male with multiple presentations to the emergency department for lower limb weakness, tremors, diaphoresis, and tachycardia. His initial blood work revealed T3-toxicosis and hypokalemia, and he was treated for TPP with intravenous fluids and potassium supplementation. He had been ingesting weight loss supplements containing iodine, kelp, licorice, and likely undeclared thyroid hormones or mimics. Following discontinuation of supplements, all laboratory investigations normalized and thyrotoxicosis symptoms resolved. This case illustrates that ingestion of thyroid hormone-based nutraceuticals should be considered as a cause of thyrotoxicosis and TPP. RésuméLa paralysie périodique thyréotoxique (PPT) se caractérise par de la faiblesse musculaire, une aréflexie et une hypokaliémie dans le contexte de la thyréotoxicose. Nous exposons le cas d’un homme de 32 ans qui s’est présenté au service des urgences pour de multiples symptômes, soit une faiblesse des membres inférieurs, des tremblements, une diaphorèse et une tachycardie. Son bilan sanguin initial a révélé une toxicose-T3 et une hypokaliémie, et il a été traité contre la PPT par des solutés intraveineux et une recharge en potassium. Il ingérait des suppléments pour la perte de poids contenant de l’iode, de la laminaire, de la réglisse et probablement des hormones thyroïdiennes ou leurs analogues non déclarés. Après l’arrêt des suppléments, tous les examens de laboratoire sont revenus à la normale et les symptômes de thyréotoxicose ont disparu. Ce cas montre que l’ingestion de nutraceutiques à base d’hormones thyroïdiennes devrait être considérée comme une cause de la thyréotoxicose et de la PPT.


2019 ◽  
Author(s):  
Sing Yee Sim ◽  
Michael Pierides ◽  
Kishor Patel ◽  
Hamidreza Mani

Author(s):  
Ayca Inci ◽  
Ali Rıza Caliskan ◽  
Melahat Coban ◽  
Refik Olmaz ◽  
Suheyla Ayca Gulenay ◽  
...  

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