Low cardiac output in pregnancy and risk of intrauterine growth restriction

2003 ◽  
Vol 189 (6) ◽  
pp. S94
Author(s):  
Jeffrey Ridgeway ◽  
Darcy Carr ◽  
Thomas Easterling
Keyword(s):  
Cardiac Output ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Low Cardiac Output ◽  
Intrauterine Growth ◽  
In Pregnancy

NT-proBNP levels in preeclampsia, intrauterine growth restriction as well as in the prediction on an imminent delivery

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Paula Lafuente-Ganuza ◽  
Fran Carretero ◽  
Paloma Lequerica-Fernández ◽  
Ana Fernandez-Bernardo ◽  
Ana I. Escudero ◽  
...  
Keyword(s):  
Cardiac Output ◽  
Early Onset ◽  
Intrauterine Growth Restriction ◽  
Left Atrial ◽  
Late Onset ◽  
Growth Restriction ◽  
Low Cardiac Output ◽  
Intrauterine Growth ◽  
High Positive Predictive Value ◽  
Early Onset Preeclampsia

Abstract Objectives Studies of cardiovascular function in pregnancy have shown inconsistent and, in some cases, contradictory results, particularly regarding cardiac output. While some studies report preeclampsia associated with high cardiac output, other studies suggest that preeclampsia should be further subdivided into women with high or low cardiac output. This study was conducted to examine the NT-proBNP levels in preeclampsia, intrauterine growth restriction, and hypertensive pregnancies without preeclampsia. We also examined N-terminal pro-B natriuretic peptide (NT-proBNP) levels three to four months after delivery, in preeclamptic women as well as the prediction of delivery within 10 days. In a reduced number of preeclamptic women and controls we performed echocardiograms to study their diastolic function. Methods We investigated the NT-proBNP levels in 213 subjects with preeclampsia only, 73 with intrauterine growth restriction, 44 with preeclampsia and intrauterine growth restriction, 211 who were hypertensive and 662 unaffected pregnancies (controls). We also performed echocardiograms on 36 preeclampsia and 19 controls before delivery and three to five months after delivery. Results NT-proBNP levels are higher in early onset preeclampsia than in late onset preeclampsia. Intrauterine growth restriction pregnancies showed a NT-proBNP levels similar to hypertensive and unaffected pregnancies. Compared with healthy pregnancies, women with preterm preeclampsia (<37 gestational weeks) had altered left atrial segments. Conclusions We observed that NT-proBNP levels are higher in early onset preeclampsia than in late onset. Moreover, diastolic dysfunction is higher in early onset than in late-onset term preeclampsia. An NT-proBNP value >136 pg/mL has a high positive predictive value for an imminent delivery within 10 days.

scholarly journals Maternal and perinatal outcomes of hyperthyroidsm in pregnancy at Dr. Cipto Mangunkusumo Hospital, Jakarta, period of January 2015 - December 2016

2021 ◽  
Vol 29 (1) ◽  
pp. 36
Author(s):  
Fita Maulina ◽  
M Adya F F Dilmy ◽  
Ali Sungkar
Keyword(s):  
Pregnant Women ◽  
Preterm Delivery ◽  
Intrauterine Growth Restriction ◽  
Fetal Death ◽  
Perinatal Outcomes ◽  
Growth Restriction ◽  
Intrauterine Fetal Death ◽  
Adequate Treatment ◽  
Intrauterine Growth ◽  
In Pregnancy

Objectives: To report maternal and perinatal outcomes of hyperthyroidsm in pregnancy.Case Report: There were 3622 cases of delivering pregnant women during the period of the study. From this number, the prevalence of pregnant women with hyperthyroid was 0.2 %. We reported 9 cases of hyperthyroid in pregnancy. The number of pregnancy complication and outcome on pregnant women with hyperthyroidism were preterm labor (44%) and preeclampsia (22%), both were found in group of mother who did taking antihyperthyroid therapy. In those who did not take antihyperthyroid therapy 11% had spontaneous abortion and 11% had preterm delivery. Fetal complications were intrauterine growth restriction (11%) and intrauterine fetal death (23%), both of these complication were on the group who did not take antihyperthyroid. On the contrary, 44% babies were born with normal birthweight in group who took antihyperthyroid.Conclusion: There were differences noted between the group that took adequate treatment and the group that did not take antihyperthyroid. The incidence of intrauterine growth restriction and intrauterine fetal death were high in group that did not took antihyperthyroid therapy but the incidence of preterm delivery as the maternal complication was high in group that did take the antihyperthyroid therapy.  

scholarly journals Selenium is a functional component of the female reproductive system. Its role in pregnancy complications

2021 ◽  
Vol 4 (4) ◽  
pp. 328-332
Author(s):  
G.K. Sadykova ◽  
◽  
A.A. Olina ◽  
◽  
Keyword(s):  
Reproductive System ◽  
Pregnancy Complications ◽  
Premature Birth ◽  
Intrauterine Growth Restriction ◽  
Placental Insufficiency ◽  
Growth Restriction ◽  
Female Reproductive System ◽  
Functional Component ◽  
Intrauterine Growth ◽  
In Pregnancy

This paper reviews studies on selenium (Se) in human reproduction. Low Se intake is associated with the development of gestational hypertension, miscarriage, premature birth, intrauterine growth restriction, and thyroid gland dysfunction. Therefore, studies on the association between Se deficiency and impaired folliculogenesis, steroidogenesis, and infertility in women are of great interest. Unfortunately, these studies are scarce, and further studies are needed. A significant antioxidant activity of Se-containing enzymes allows for minimizing risks of obstetrical complications associated with placental insufficiency. Therefore, selenium is vital for realizing female reproductive function. However, even given potential risks of insufficient Se-containing product intake, the authors find it unacceptable to recommend Se dotation in the population since toxic effects of Se excess are yet to be fully explored. Further studies on Se biological effects will extend the scope of its use in obstetrics and gynecology in terms of a preventive approach. KEYWORDS: selenium, placental insufficiency, folliculogenesis, steroidogenesis, antioxidant, miscarriage, premature birth, intrauterine growth restriction. FOR CITATION: Sadykova G.K., Olina A.A. Selenium is a functional component of the female reproductive system. Its role in pregnancy complications. Russian Journal of Woman and Child Health. 2021;4(4):328–332 (in Russ.). DOI: 10.32364/2618-8430-2021-4-4- 328-332.

scholarly journals Placental growth factor reverses decreased vascular and uteroplacental MMP-2 and MMP-9 and increased MMP-1 and MMP-7 and collagen types I and IV in hypertensive pregnancy

2018 ◽  
Vol 315 (1) ◽  
pp. H33-H47 ◽  
Author(s):  
Zongli Ren ◽  
Ning Cui ◽  
Minglin Zhu ◽  
Raouf A. Khalil
Keyword(s):  
Growth Factor ◽  
Tyrosine Kinase ◽  
Intrauterine Growth Restriction ◽  
Placental Growth Factor ◽  
Angiogenic Factors ◽  
Growth Restriction ◽  
Collagen Types ◽  
Intrauterine Growth ◽  
Placental Ischemia ◽  
In Pregnancy

Preeclampsia is a complication of pregnancy manifested as maternal hypertension (HTN) and fetal intrauterine growth restriction, with unclear mechanisms. Placental ischemia increases antiangiogenic soluble fms-like tyrosine kinase-1 (sFlt-1) relative to angiogenic placental growth factor (PlGF); however, the molecular targets are unclear. To test the hypothesis that placental ischemia-induced changes in sFlt-1 and PlGF target vascular and uteroplacental matrix metalloproteinases (MMPs), we tested whether raising the sFlt-1-to-PlGF ratio by infusing sFlt-1 (10 µg·kg−1·day−1) in pregnant (Preg) rats increases blood pressure (BP) and alters MMPs and whether correcting sFlt-1/PlGF by infusing PlGF (20 µg·kg−1·day−1) in Preg rats with reduced uterine perfusion pressure (RUPP) improves BP and reverses the changes in MMPs. On gestational day 19, BP was higher and the litter size and uterine, placenta, and pup weight were less in Preg + sFlt-1 and RUPP than Preg rats and restored in RUPP + PlGF versus RUPP rats. Gelatin and casein zymography and Western blots revealed decreases in MMP-2 and MMP-9 and increases in MMP-1 and MMP-7 in the aorta, uterine artery, uterus, and placenta of Preg + sFlt-1 and RUPP versus Preg rats, which were reversed in RUPP + PlGF versus RUPP rats. Collagen types I and IV were more abundant in Preg + sFlt-1 and RUPP versus Preg rats and were reversed in RUPP + PlGF versus RUPP rats. Thus, PlGF reverses decreased vascular and uteroplacental MMP-2 and MMP-9 and increased MMP-1, MMP-7, and collagen types I and IV induced by placental ischemia and sFlt-1 in HTN in pregnancy. Angiogenic factors and MMP modulators could rectify changes in MMPs and collagen, restore vascular and uteroplacental remodeling, and improve HTN and intrauterine growth restriction in preeclampsia. NEW & NOTEWORTHY Understanding the mechanisms of preeclampsia could help in its prevention and management. This study shows that correcting soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) imbalance by infusing PlGF reverses the decreases in vascular and uteroplacental matrix metalloproteinase (MMP)-2 and MMP-9 and the increases in MMP-1, MMP-7, and collagen types I and IV induced by placental ischemia and antiangiogenic sFlt-1 in hypertension in pregnancy. Angiogenic factors and MMP modulators could rectify changes in vascular and uteroplacental MMPs and collagen content and ameliorate hypertension and intrauterine growth restriction in preeclampsia.

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