O133. Fetal renal vascularisation in pregnancy induced hypertension complicated by gestational diabetes or intrauterine growth restriction

2015 ◽  
Vol 5 (3) ◽  
pp. 241-242
Author(s):  
Andrea Surányi ◽  
Ábel Altorjay ◽  
Gábor Németh
Keyword(s):  
Gestational Diabetes ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Pregnancy Induced Hypertension ◽  
Intrauterine Growth ◽  
Induced Hypertension ◽  
In Pregnancy

scholarly journals Role of Umbilical Artery Doppler in Predicting Intrauterine Growth Restriction and Foetal Outcome in Pregnant Ladies with Pregnancy Induced Hypertension

2018 ◽  
Vol 7 (1-2) ◽  
pp. 3-8
Author(s):  
Prakash Sharma ◽  
Merina Gyawali ◽  
Sangita Devi Gurung
Keyword(s):  
Intrauterine Growth Restriction ◽  
Umbilical Artery ◽  
Clinical Suspicion ◽  
Growth Restriction ◽  
Pregnancy Induced Hypertension ◽  
Intrauterine Growth ◽  
Induced Hypertension ◽  
Umbilical Artery Doppler ◽  
Foetal Outcome

Introduction: Umbilical artery Doppler is a noninvasive tool in the evaluation of the foetal and uteroplacental circulation. The aim of this study was to evaluate the role of umbilical artery Doppler in pregnancy induced hypertension (PIH) ladies with clinical suspicion of intrauterine growth restriction (IUGR) and to predict the fetal outcome.Methods: A total of 44 singleton pregnancies beyond 34 weeks of pregnancy complicated with pregnancy induced hypertension and clinical suspicion of intrauterine growth restriction were evaluated using ultrasonography and Doppler. Six pregnant ladies were excluded from the study. The umbilical artery systolic/diastolic (S/D) ratio was calculated from a free loop of cord midway between the placenta and insertion of cord. All the pregnant ladies were followed up till delivery. Birth weight, adverse foetal outcome were recorded. Babies were divided into two groups, small for gestational age (SGA) and appropriate for gestational age (AGA) based on Lubchenco growth chart. SGA was considered as IUGR.Results: Abnormal S/D in umbilical artery was seen in 26 pregnant ladies, out of which 22 had an abnormal resistive index (RI). Umbilical artery S/D ratio had a sensitivity of 66.7% and specificity of 28.57%, in diagnosing IUGR. Umbilical artery RI had a sensitivity of 50% and specificity of 28.6% in diagnosing IUGR. Similarly, S/D ratio of the umbilical artery had a sensitivity of 100 %, specificity of 46.2%, in diagnosing adverse foetal outcome. RI was 100% sensitive in diagnosing foetal outcome.Conclusion: Umbilical artery Doppler plays an important role in PIH in diagnosing IUGR and predicting a foetal outcome.

scholarly journals Oxidative Stress Markers Differ in Two Placental Dysfunction Pathologies: Pregnancy-Induced Hypertension and Intrauterine Growth Restriction

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Aleksandra Zygula ◽  
Przemyslaw Kosinski ◽  
Piotr Wroczynski ◽  
Magdalena Makarewicz-Wujec ◽  
Bronislawa Pietrzak ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oral Health ◽  
Oral Cavity ◽  
Intrauterine Growth Restriction ◽  
The State ◽  
Growth Restriction ◽  
Control Group ◽  
Pregnancy Induced Hypertension ◽  
Intrauterine Growth ◽  
Induced Hypertension

Aim. Pregnancy-induced hypertension (PIH) and intrauterine growth restriction (IUGR) are both multisystemic disorders of pregnancy that cause perinatal morbidity and mortality. Recently, researchers focused on the role of oxidative stress (OS) as a pathophysiological mechanism in the development of these pathologies. The aim of this study was to compare OS in placental-related pathologies (PIH and IUGR) and uncomplicated pregnancies. We also investigated which salivary OS markers reflect systemic oxidative status and which only reflect the state of the oral cavity. Material and Methods. A total of 104 pregnant women (n=104; 27 with PIH, 30 with IUGR, and 47 controls) were evaluated. Malondialdehyde (MDA), total antioxidant capacity (ORAC), aldehyde dehydrogenase (ALDH), and activity of glutathione peroxidase (GPx) and glutathione transferase (GST) in plasma/whole blood and/or saliva were analysed. Dietary nutrient intake was calculated using a Semiquantitative Food Frequency Questionnaire (SFFQ). Oral health was assessed to eliminate patients with bleeding, severe periodontitis, and other dental pathologies. Results. In the IUGR group, increased concentration of ORAC was observed both in saliva and plasma. Also, lower plasma levels of MDA in IUGR compared to the control group was detected. No sign of oxidative stress was confirmed in the PIH group. The examined groups did not differ regarding diet and markers of inflammation. ORAC in saliva was correlated with its level in plasma. No such correlations for MDA were observed. In the IUGR group, there were no differences in OS markers in plasma, but there was a lower ALDH level in the blood compared to the control group. It confirms OS occurrence in IUGR. In IUGR, a higher activity of salivary ALDH was probably due to worse oral health. Conclusion. Oxidative stress differs between IUGR and PIH groups: the presence of oxidative stress was confirmed only in the IUGR group. Salivary ORAC can be used to estimate ORAC in plasma. The activity of salivary ALDH reflects the state of the oral cavity.

scholarly journals Maternal and perinatal outcomes of hyperthyroidsm in pregnancy at Dr. Cipto Mangunkusumo Hospital, Jakarta, period of January 2015 - December 2016

2021 ◽  
Vol 29 (1) ◽  
pp. 36
Author(s):  
Fita Maulina ◽  
M Adya F F Dilmy ◽  
Ali Sungkar
Keyword(s):  
Pregnant Women ◽  
Preterm Delivery ◽  
Intrauterine Growth Restriction ◽  
Fetal Death ◽  
Perinatal Outcomes ◽  
Growth Restriction ◽  
Intrauterine Fetal Death ◽  
Adequate Treatment ◽  
Intrauterine Growth ◽  
In Pregnancy

Objectives: To report maternal and perinatal outcomes of hyperthyroidsm in pregnancy.Case Report: There were 3622 cases of delivering pregnant women during the period of the study. From this number, the prevalence of pregnant women with hyperthyroid was 0.2 %. We reported 9 cases of hyperthyroid in pregnancy. The number of pregnancy complication and outcome on pregnant women with hyperthyroidism were preterm labor (44%) and preeclampsia (22%), both were found in group of mother who did taking antihyperthyroid therapy. In those who did not take antihyperthyroid therapy 11% had spontaneous abortion and 11% had preterm delivery. Fetal complications were intrauterine growth restriction (11%) and intrauterine fetal death (23%), both of these complication were on the group who did not take antihyperthyroid. On the contrary, 44% babies were born with normal birthweight in group who took antihyperthyroid.Conclusion: There were differences noted between the group that took adequate treatment and the group that did not take antihyperthyroid. The incidence of intrauterine growth restriction and intrauterine fetal death were high in group that did not took antihyperthyroid therapy but the incidence of preterm delivery as the maternal complication was high in group that did take the antihyperthyroid therapy.  

scholarly journals Exploring Fetal Sex as a Risk Factor for Sleep Disordered Breathing and Its Complications in Pregnancy

2020 ◽  
Vol 4 ◽  
pp. 247028972094807
Author(s):  
Margaret H. Bublitz ◽  
Myriam Salameh ◽  
Laura Sanapo ◽  
Ghada Bourjeily
Keyword(s):  
Gestational Diabetes ◽  
Pregnancy Complications ◽  
Sleep Disordered Breathing ◽  
Pregnancy Induced Hypertension ◽  
Hypertensive Disorders Of Pregnancy ◽  
Fetal Sex ◽  
Hypertensive Disorders ◽  
Induced Hypertension ◽  
In Pregnancy ◽  
Disordered Breathing

Sleep disordered breathing (SDB) is a common, yet under-recognized and undertreated condition in pregnancy. Sleep disordered breathing is associated with pregnancy complications including preeclampsia, gestational diabetes, preterm birth, as well as severe maternal morbidity and mortality. The identification of risk factors for SDB in pregnancy may improve screening, diagnosis, and treatment of SDB prior to the onset of pregnancy complications. The goal of this study was to determine whether fetal sex increases risk of SDB in pregnancy. A cohort of singleton (N = 991) pregnant women were recruited within 24 to 48 hours of delivery and answered questions regarding SDB symptoms by questionnaire. Women who reported frequent loud snoring at least 3 times a week were considered to have SDB. Hospital records were reviewed to extract information on fetal sex and pregnancy complications including preeclampsia, pregnancy-induced hypertension, gestational diabetes, preterm delivery, and low birth weight. Women carrying male fetuses were significantly more likely to have SDB (β = .37, P = .01, OR: 1.45 [95% CI: 1.09-1.94]). Fetal sex was associated with increased risk of hypertensive disorders of pregnancy (defined as preeclampsia and/or pregnancy-induced hypertension) among women with SDB in pregnancy (β = .41, P = .02, OR: 1.51 [95% CI: 1.08-2.11]). Fetal sex did not increase risk of preterm birth, low birth weight, or gestational diabetes among women with SDB in pregnancy. Women carrying male fetuses were approximately 1.5 times more likely to report SDB in pregnancy compared to women carrying female fetuses, and women with pregnancy-onset SDB carrying male fetuses were 1.5 times more likely to have hypertensive disorders of pregnancy compared to women with SDB carrying female fetuses. Confirmation of fetal sex as a risk factor may, with other risk factors, play a role in identifying women at highest risk of SDB complications in pregnancy.

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