A case of Epstein-Barr virus-positive mucocutaneous ulcer in the right tongue that disappeared after treatment for oral candidiasis

2021 ◽  
Author(s):  
Tomoyo Nozato ◽  
Tomomichi Ozawa ◽  
Mikio Ozawa ◽  
Kohei Osawa ◽  
Makoto Hirota ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Oral Candidiasis ◽  
Barr Virus ◽  
Epstein Barr ◽  
The Right

scholarly journals Epstein-Barr virus meningoencephalitis in a immunocompetent child

2021 ◽  
Author(s):  
Gustavo Carvalho Costa ◽  
Alicia Carolina Coraspe Gonçalves ◽  
Thayse Indira Bonadio Simões ◽  
Flavia Andrade Rocha Borrelli
Keyword(s):  
Epstein Barr Virus ◽  
Transverse Myelitis ◽  
Barr Virus ◽  
Level Of Consciousness ◽  
Midbrain Region ◽  
Left Caudate ◽  
Diagnostic Hypothesis ◽  
Dystonic Posture ◽  
Epstein Barr ◽  
The Right

Introduction: Meningoencephalitis caused by the Epstein-Barr virus (EBV) is a rare neurological entity, most often related to the latent reactivation of thevirus associated with immunosuppression. The clinic varies between encephalitis, meningitis, cerebellitis, neuritis and transverse myelitis. The prognosis is good, with 85% of patients returning to baseline levels. Case report: We attend to a 11-month-old male patient, proper neuropsychomotor development, with reports of fever and odynophagia, without improvement with antibiotic therapy. He had a focal epileptic seizure. Upon admission, he presented a new similar event, with control after use of diazepam and intravenous phenobarbital. At the neurological examination carried out after improving the level of consciousness, the patient was alert. He presented axial hypotonia, dystonic posture in flexion of the right upper limb, with preserved strength. He showed no meningeal signs. The cerebrospinal fluid revealed 61 mg/dL of glucose, 57 mg/dL of proteins and 65/mm³ of leukocytes (90% of lymphocytes). Acyclovir, ceftriaxone, and dexamethasone were started, with improvement. Magnetic resonance imaging revealed: FLAIR hyper signal injury, with diffusion restriction, in the left caudate nucleus, left lentiform and ipsilateral anterior midbrain region. Electroencephalogram with diffuse attenuation of baseline electrical activity. The main diagnostic hypothesis was meningoencephalitis secondary to EBV infection, with confirmatory PCR-DNA. Conclusion: The report illustrates the need for attention to a rare infectious etiology in atypical presentation of meningoencephalitis.

scholarly journals Primary Intraocular Lymphoma in a Patient with Bilateral Epstein-Barr Virus Panuveitis: A Case Report

2021 ◽  
Author(s):  
Seyedeh Maryam Hosseini ◽  
Mojtaba Abrishami ◽  
Elham Barashki ◽  
Ghodsieh Zamani
Keyword(s):  
B Cell ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
Antiviral Treatment ◽  
B Cell Lymphoma ◽  
Intraocular Lymphoma ◽  
Primary Intraocular Lymphoma ◽  
Barr Virus ◽  
Epstein Barr ◽  
The Right

Abstract Purpose: Herein, we report a case of primary intraocular lymphoma (PIOL) with the first presentation of bilateral Epstein-Barr virus (EBV)-associated panuveitis and retinitis.Case presentation: A 69-year-old male was referred with a three-day history of blurred vision and pain and redness in his left eye following cataract surgery. Ophthalmic examination revealed panuveitis, vitritis, and necrotizing retinitis with retinal hemorrhage. A month later, the right eye was also involved. Initially, the clinical diagnosis of acute retinal necrosis was made based on clinical manifestation; however, the partial response to intravenous and intravitreal antiviral treatment in the left eye and involvement of the right eye resulted in further investigation of masquerade syndromes. Polymerase chain reaction-based analysis of vitreous sample was positive for EBV, and cytological evaluation was compatible with the diagnosis of B-cell lymphoma. A significant improvement was observed following serial intravitreal rituximab and methotrexate injections. The central nervous system and lungs were involved after 6 months, and the patient expired despite treatment with systemic chemotherapy. Conclusion: There may be an association between EBV panuveitis and primary intraocular B-cell lymphoma.

scholarly journals A new therapy in Epstein-Barr virus-associated lymphoproliferative disease: a case report and a revision of the literature

2019 ◽  
Vol 45 (1) ◽  
Author(s):  
Lingling Xu ◽  
Hongjun Ba ◽  
Hongrong Lin ◽  
Liangying Zhong ◽  
Suping Li ◽  
...  
Keyword(s):  
Virus Infection ◽  
Lymphoproliferative Disorder ◽  
Epstein Barr Virus ◽  
Internal Carotid ◽  
Lymphoproliferative Disease ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection ◽  
The Right

Abstract Background Systemic chronic active Epstein-Barr virus infection is an extremely rare childhood disease. Since chronic active Epstein-Barr virus infection can trigger the onset of Epstein-Barr virus-associated lymphoproliferative disease. The clinical manifestations of the disease vary according to the site of involvement; therefore, management may be challenging. Currently, there are no standardized guidelines for treating Chronic active Epstein-Barr virus infection effectively. Case presentation We report a case of chronic active Epstein-Barr virus infection in a 5-year-old Chinese boy with intestinal, vascular, and neurological involvement. At age of 2 years and 7 months old, he had hepatomegaly and been diagnosed with Epstein-Barr virus infection. After treatment, he showed some clinical improvement. At age of 3 years and 3 months old, he presented with recurrent fever and diarrhea. Then he received methylprednisolone for 1 year and his symptoms ameliorated. At the age of 5 years, his symptoms recurred and had gastrointestinal hemorrhage and developed polyuria, frequent convulsions and hyponatremia. He was transferred to our hospital for further management. He was unconscious on admission and was diagnosised Epstein-Barr virus-lymphoproliferative disorder, based on the results in situ hybridization of EBV-encoded miRNA in sigmoid colon. Three-dimensional CT angiography demonstrated an aneurysm in the right internal carotid artery. Abdominal CT showed dilatation of vessels in part of the intestinal wall. He was also diagnosised Epstein-Barr virus encephalitis based on the elevated Epstein-Barr virus antibody titers and presence of Epstein-Barr virus DNA in the Cerebrospinal Fluid. A repeated duodenal artery embolization and symptomatic therapy could not control the hemorrhage after admission. He subsequently received treatment with ganciclovir, glucocorticoid, thalidomide, and propranolol. Hemorrhage was controlled in 5 days; his symptoms improved. The fever did not recur and the CSF pressure was also normalized. A follow-up CT at 3 months after admission showed regression of the aneurysm in the right internal carotid artery and the vascular lesion in the duodenum. Discussion and conclusions A new treatment protocol including thalidomide and propranolol resulted in a marked improvement in his clinical symptoms, and shows promise as a novel and effective therapeutic approach for Chronic active Epstein-Barr virus infection-associated lymphoproliferative disorder.

Epstein-Barr Virus-Positive Pyothorax-Associated Lymphoma Arising from a Posttraumatic Empyema

2015 ◽  
Vol 134 (3) ◽  
pp. 155-160 ◽  
Author(s):  
Ayuko Taniguchi ◽  
Yumiko Hashida ◽  
Yuiko Nemoto ◽  
Hisanori Machida ◽  
SungGi Chi ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Phenotypic Change ◽  
Barr Virus ◽  
Phenotypic Alteration ◽  
Lung Tuberculosis ◽  
First Case ◽  
Resected Tumor ◽  
Artificial Pneumothorax ◽  
Epstein Barr ◽  
The Right

Pyothorax-associated lymphoma (PAL) develops from a pyothorax caused by an artificial pneumothorax created during the treatment of pulmonary tuberculosis or tuberculous pleuritis. We report the first case of Epstein-Barr virus (EBV)-positive PAL arising from a posttraumatic empyema. A 75-year-old woman with chronic posttraumatic empyema presented with a tumor, which was connected to the wall of a pyothorax in the right thoracic cavity. She had a history of trauma to the right chest, which had occurred at the age of 45 years and had caused the chronic posttraumatic empyema. Pathological features of the resected tumor were conclusive for a diagnosis of EBV-positive PAL. Although neither postoperative chemotherapy nor radiotherapy was performed, remission was maintained for 3 years until recurrence in the liver. Combination chemotherapy led to complete remission, and 9 years after the initial diagnosis of PAL, the patient is still alive. An intriguing finding is the phenotypic alteration during the disease course. Although the primary tumor was negative for CD20 and CD3, the recurrent tumor expressed both of these molecules. We discuss this case of PAL, which was not a complication of lung tuberculosis, and the aberrant chronological phenotypic change observed in the lymphoma cells, and compare it with a usual case of PAL.

scholarly journals Burkitt's Lymphoma in a 5 year old Bengali Girl: A Case Report

2011 ◽  
Vol 31 (1) ◽  
pp. 61-63
Author(s):  
I Chatterjee ◽  
A Roy
Keyword(s):  
Epstein Barr Virus ◽  
Malignant Tumors ◽  
Burkitt’S Lymphoma ◽  
Burkitt's Lymphoma ◽  
Indian Children ◽  
Barr Virus ◽  
Poorly Differentiated ◽  
Epstein Barr ◽  
Rare Malignancy ◽  
The Right

Burkitt's lymphoma (BL) is a rare monoclonal proliferation of B-lymphocytes and is classified as a poorly differentiated lymphocytic lymphoma. This tumor was first noted in Africans. The cause of this tumor is debatable, but strong evidence implicates Epstein-Barr virus in its development. This tumor predominantly affects children and is probably the fastest growing tumor in humans, with exuberant proliferation. It is a very rare malignancy accounting for only 0.76% of solid malignant tumors among Indian children. A case of BL of the right hemimandible in a 5-year-old Bengali girl is reported. Key words: Burkitt's lymphoma; Immunohistochemistry; Chemotherapy. DOI: 10.3126/jnps.v31i1.3903J Nep Paedtr Soc 2010;31(1):61-63

scholarly journals The Right Treatment of the Right Patient: Integrating Genetic Profiling Into Clinical Decision Making in Advanced Gastric Cancer in Asia

2021 ◽  
pp. 1-8
Author(s):  
Yoshiaki Nakamura ◽  
Kohei Shitara ◽  
Jeeyun Lee
Keyword(s):  
Gastric Cancer ◽  
Clinical Trials ◽  
Mismatch Repair ◽  
Epstein Barr Virus ◽  
Clinical Decision Making ◽  
Palliative Chemotherapy ◽  
Metastatic Gastric Cancer ◽  
Barr Virus ◽  
Epstein Barr ◽  
The Right

Gastric cancer is a major global health burden, especially when patients are diagnosed with recurrent or metastatic gastric cancer. Despite recent advances in treatment options with palliative chemotherapy, the median overall survival of patients with gastric cancer remains within 1 or 2 years after the diagnosis of metastatic disease. Gastric cancer is significantly more prevalent in eastern Asia (e.g., Japan and Korea). Next-generation sequencing (NGS) is rapidly being adopted as part of clinical practice in Korea and Japan, especially in patients with gastric cancer. Approximately 10% to 15% of the patients with gastric cancer who undergo NGS of their tumor specimen are allocated to target-matched clinical trials in Japan and Korea. In Japan and Korea, a cell-free DNA NGS panel is also actively being investigated as an alternative NGS test for patients with gastric cancer, which may reflect the tumor heterogeneity of gastric cancer. In Japan and Korea, multiple biomarkers, such as HER2, mismatch repair, Epstein-Barr virus, PD-L1 (combined positive score), EGFR, FGFR2, and CLDN18.2, are routinely assessed through immunohistochemistry or in situ hybridization before initiation of the first-line treatment in all patients with gastric cancer. Most tertiary cancer centers in Korea routinely perform HER2, mismatch repair, Epstein-Barr virus, and PD-L1 NGS before palliative chemotherapy in patients with gastric cancer. Biomarker evaluation for all patients with metastatic gastric cancer enables clinicians to identify available biomarker-based clinical trials early during the course of treatment, which expands treatment opportunities while patients are medically fit for clinical trials, if available. Comprehensive genomic profiling using a tissue or circulating tumor DNA NGS panel is considered necessary during second-line or subsequent treatment. It is hoped that a comprehensive molecular profiling strategy will facilitate greater use of precision medicine through molecularly targeted therapies for patients with gastric cancer in the near future.

A Quantitative Ultrastructural Study of Peripheral Blood Lymphocytes Containing Parallel Tubular Arrays in Epstein-Barr Virus and Cytomegalo-Virus Mononucleosis

1981 ◽  
Vol 39 ◽  
pp. 454-455
Author(s):  
C. M. Payne ◽  
P. M. Tennican
Keyword(s):  
Peripheral Blood ◽  
Lymphocyte Count ◽  
Epstein Barr Virus ◽  
Absolute Lymphocyte Count ◽  
Peripheral Blood Lymphocytes ◽  
Clinical State ◽  
Barr Virus ◽  
The Absolute ◽  
Epstein Barr ◽  
Tubular Arrays

In the normal peripheral circulation there exists a sub-population of lymphocytes which is ultrastructurally distinct. This lymphocyte is identified under the electron microscope by the presence of cytoplasmic microtubular-like inclusions called parallel tubular arrays (PTA) (Figure 1), and contains Fc-receptors for cytophilic antibody. In this study, lymphocytes containing PTA (PTA-lymphocytes) were quantitated from serial peripheral blood specimens obtained from two patients with Epstein -Barr Virus mononucleosis and two patients with cytomegalovirus mononucleosis. This data was then correlated with the clinical state of the patient.It was determined that both the percentage and absolute number of PTA- lymphocytes was highest during the acute phase of the illness. In follow-up specimens, three of the four patients' absolute lymphocyte count fell to within normal limits before the absolute PTA-lymphocyte count.In one patient who was followed for almost a year, the absolute PTA- lymphocyte count was consistently elevated (Figure 2). The estimation of absolute PTA-lymphocyte counts was determined to be valid after a morphometric analysis of the cellular areas occupied by PTA during the acute and convalescent phases of the disease revealed no statistical differences.

Studies of Epstein-Barr Virus Antigens Using Immunoperoxidase and Immunofluorescence Techniques

1975 ◽  
Vol 33 ◽  
pp. 342-343
Author(s):  
R. Stephens ◽  
K. Traul ◽  
D. Woolf ◽  
P. Gaudreau
Keyword(s):  
Electron Microscopy ◽  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
If Technique ◽  
Infected Cells ◽  
Virus Antigens ◽  
Epstein Barr ◽  
Virus Capsid Antigen ◽  
Antigen Reactivity

A number of antigens have been found associated with persistent EBV infections of lymphoblastoid cells. Identification and localization of these antigens were principally by immunofluorescence (IF) techniques using sera from patients with nasopharyngeal carcinoma (NPC), Burkitt lymphoma (BL), and infectious mononucleosis (IM). Our study was mainly with three of the EBV related antigens, a) virus capsid antigen (VCA), b) membrane antigen (MA), and c) early antigens (EA) using immunoperoxidase (IP) techniques with electron microscopy (EM) to elucidate the sites of reactivity with EBV and EBV infected cells.Prior to labeling with horseradish peroxidase (HRP), sera from NPC, IM, and BL cases were characterized for various reactivities by the indirect IF technique. Modifications of the direct IP procedure described by Shabo and the indirect IP procedure of Leduc were made to enhance penetration of the cells and preservation of antigen reactivity.

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