Background
Macular holes are vitreoretinal interface disorders due to anatomical defects in the
fovea causing poor central vision. The aim of this study was to compare the results of
four different variants of inverted flap (IF) technique, for the closure of macular holes
larger than 400µm.
Methods
This is a prospective comparative case series. Thirty-six eyes with large macular hole
were enrolled: group 1: inserted internal limiting membrane (ILM); group 2: classic IF
ILM; group 3: IF without manipulation (Free Flap technique), group 4: temporal IF
technique. Best-corrected visual acuity (BCVA), anatomical closure rate, and ellipsoid
zone (EZ) and external limiting membrane (ELM) defects were evaluated
preoperatively, at 1 month and 3 months after surgery. Odds ratio (OR) and its 95%
confidence interval (CI) were used to compare the anatomical and functional results
of classic inverted flap ILM peeling (group 2) and modified inverted flap ILM peeling
(Group 1,3 and 4).
Results
Mean BCVA improved in all four groups 3 months after surgery. The improvement
was significant in group 2,3, and 4 (P=0.001). The rate of successful hole closure
ranged from 87.5% to 100% in different groups (P=0.661). The integrity of EZ was
achieved in 65.6% and the restoration of the inner layers of the retina in 71.5%.
Conclusion
Inverted flap ILM technique is efficient for the treatment of large full thickness
macular hole (FTMH). Different modified inverted flap techniques have been
described on the last decade. Through our study, we demonstrated that the inserted
flap, may alter outer retinal layer and compromise final functional results despite final
closure of the macular hole. The classic IF technique, the temporal and the free flap
techniques have finally comparable good functional and anatomical results.
Key words
inverted flap technique, macular hole, surgery, outcomes