scholarly journals Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction

2017 ◽  
Vol 187 (11) ◽  
pp. 2413-2429 ◽  
Author(s):  
Stephanie Schwalm ◽  
Sandra Beyer ◽  
Helena Frey ◽  
Riad Haceni ◽  
Georgios Grammatikos ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ureteral Obstruction ◽  
Sphingosine Kinase ◽  
Unilateral Ureteral Obstruction ◽  
Kidney Fibrosis ◽  
Sphingosine Kinase 2

scholarly journals Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0194053 ◽  
Author(s):  
Mallika Ghosh ◽  
Shobha Thangada ◽  
Oisharya Dasgupta ◽  
Kamal M. Khanna ◽  
Harold T. Yamase ◽  
...  
Keyword(s):  
Ureteral Obstruction ◽  
Macrophage Polarization ◽  
Sphingosine Kinase ◽  
Unilateral Ureteral Obstruction ◽  
Renal Inflammation ◽  
Sphingosine Kinase 2

The antifibrotic and anti-inflammatory effects of icariin on the kidney in a unilateral ureteral obstruction mouse model

Phytomedicine ◽  
2019 ◽  
Vol 59 ◽  
pp. 152917 ◽  
Author(s):  
Hsin‐An Chen ◽  
Chang-Mu Chen ◽  
Siao-Syun Guan ◽  
Chih-Kang Chiang ◽  
Cheng-Tien Wu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ureteral Obstruction ◽  
Unilateral Ureteral Obstruction ◽  
Anti Inflammatory

scholarly journals Matrix Metalloproteinase-2 Knockout and Heterozygote Mice Are Protected from Hydronephrosis and Kidney Fibrosis after Unilateral Ureteral Obstruction

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0143390 ◽  
Author(s):  
Maria K. Tveitarås ◽  
Trude Skogstrand ◽  
Sabine Leh ◽  
Frank Helle ◽  
Bjarne M. Iversen ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Ureteral Obstruction ◽  
Unilateral Ureteral Obstruction ◽  
Matrix Metalloproteinase 2 ◽  
Kidney Fibrosis

Fate alteration of bone marrow-derived macrophages ameliorates kidney fibrosis in murine model of unilateral ureteral obstruction

2018 ◽  
Vol 34 (10) ◽  
pp. 1657-1668 ◽  
Author(s):  
Ying Yang ◽  
Xiaojian Feng ◽  
Xinyan Liu ◽  
Ying Wang ◽  
Min Hu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Ureteral Obstruction ◽  
Renal Fibrosis ◽  
Kidney Diseases ◽  
Unilateral Ureteral Obstruction ◽  
Immunofluorescent Staining ◽  
Enzyme Linked Immunosorbent Assay ◽  
Pathological Feature ◽  
Kidney Fibrosis ◽  
Anti Inflammatory

AbstractBackgroundRenal fibrosis is a key pathological feature and final common pathway leading to end-stage kidney failure in many chronic kidney diseases. Myofibroblast is the master player in renal fibrosis. However, myofibroblasts are heterogeneous. Recent studies show that bone marrow-derived macrophages transform into myofibroblasts by transforming growth factor (TGF)-β-induced macrophage–myofibroblast transition (MMT) in renal fibrosis.MethodsTGF-β signaling was redirected by inhibition of β-catenin/T-cell factor (TCF) to increase β-catenin/Foxo in bone marrow-derived macrophages. A kidney fibrosis model of unilateral ureteral obstruction was performed in EGFP bone marrow chimera mouse. MMT was examined by flow cytometry analysis of GFP+F4/80+α-SMA+ cells from unilateral ureteral obstruction (UUO) kidney, and by immunofluorescent staining of bone marrow-derived macrophages in vitro. Inflammatory and anti-inflammatory cytokines were analysis by enzyme-linked immunosorbent assay.ResultsInhibition of β-catenin/TCF by ICG-001 combined with TGF-β1 treatment increased β-catenin/Foxo1, reduced the MMT and inflammatory cytokine production by bone marrow-derived macrophages, and thereby, reduced kidney fibrosis in the UUO model.ConclusionsOur results demonstrate that diversion of β-catenin from TCF to Foxo1-mediated transcription not only inhibits the β-catenin/TCF-mediated fibrotic effect of TGF-β, but also enhances its anti-inflammatory action, allowing therapeutic use of TGF-β to reduce both inflammation and fibrosis at least partially by changing the fate of bone marrow-derived macrophages.

scholarly journals Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis

2021 ◽  
Vol 79 ◽  
pp. 109881
Author(s):  
Stephanie Schwalm ◽  
Sandra Beyer ◽  
Redona Hafizi ◽  
Sandra Trautmann ◽  
Gerd Geisslinger ◽  
...  
Keyword(s):  
Mouse Model ◽  
Treatment Options ◽  
Sphingosine Kinase ◽  
Tubulointerstitial Fibrosis ◽  
Sphingosine Kinase 2

Longitudinal changes in MRI markers in a reversible unilateral ureteral obstruction mouse model: Preliminary experience

2013 ◽  
Vol 39 (4) ◽  
pp. 835-841 ◽  
Author(s):  
Muhammad E. Haque ◽  
Tammy Franklin ◽  
Ujala Bokhary ◽  
Liby Mathew ◽  
Bradley K. Hack ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ureteral Obstruction ◽  
Unilateral Ureteral Obstruction ◽  
Longitudinal Changes

A UNILATERAL URETERAL OBSTRUCTION MOUSE MODEL IS APPLIED TO INVESTIGATE THE PATHOPHYSIOLOGY OF OBSTRUCTED URETERS

2009 ◽  
Vol 181 (4S) ◽  
pp. 721-721 ◽  
Author(s):  
Kwadwo Owusu-Ofori ◽  
Eric Wilkinson ◽  
William S Mellon ◽  
Stephen Y Nakada
Keyword(s):  
Mouse Model ◽  
Ureteral Obstruction ◽  
Unilateral Ureteral Obstruction
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