scholarly journals Dry skin manifestations in Sjögren syndrome and atopic dermatitis related to aberrant sudomotor function in inflammatory allergic skin diseases

2018 ◽  
Vol 67 (4) ◽  
pp. 448-454 ◽  
Author(s):  
Ichiro Katayama
Keyword(s):  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Dry Skin ◽  
Sudomotor Function ◽  
Skin Manifestations ◽  
Allergic Skin

Calcineurin Inhibitors: A Novel Approach to Canine Atopic Dermatitis

2005 ◽  
Vol 41 (2) ◽  
pp. 92-97 ◽  
Author(s):  
Rosanna Marsella
Keyword(s):  
Atopic Dermatitis ◽  
Adverse Effects ◽  
Mechanism Of Action ◽  
Broad Spectrum ◽  
Skin Diseases ◽  
Calcineurin Inhibitors ◽  
Relevant Information ◽  
Novel Approach ◽  
Allergic Skin ◽  
Traditional Therapies

The introduction of calcineurin inhibitors represents a major addition to the armamentarium of drugs available to veterinary clinicians for the management of allergic skin diseases. Both cyclosporine and tacrolimus have been proven to be well tolerated and effective for the treatment of atopic dermatitis in dogs. Although broad spectrum in their mechanism of action, they lack the major adverse effects of glucocorticoids and provide an appealing alternative to traditional therapies. The purposes of this article are to review clinically relevant information regarding these agents and to provide tips for maximizing the benefit obtained from these therapies.

scholarly journals Intertwined vascular skin manifestations in a patient with Sjögren syndrome: A case report

2021 ◽  
Author(s):  
Masakazu Kakurai ◽  
Naoko Okiyama ◽  
Tatsuya Ogawa ◽  
Maki Fukuzono ◽  
Noriko Kubota ◽  
...  
Keyword(s):  
Case Report ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Skin Manifestations

scholarly journals The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch

2021 ◽  
Vol 118 (13) ◽  
pp. e2022087118
Author(s):  
Tiphaine Voisin ◽  
Caroline Perner ◽  
Marie-Angele Messou ◽  
Stephanie Shiers ◽  
Saltanat Ualiyeva ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Skin Diseases ◽  
Chronic Phase ◽  
Drg Neurons ◽  
Dry Skin ◽  
Chronic Itch ◽  
Allergic Skin ◽  
Dose Dependent ◽  
Type 2 Inflammation

Acute and chronic itch are burdensome manifestations of skin pathologies including allergic skin diseases and atopic dermatitis, but the underlying molecular mechanisms are not well understood. Cysteinyl leukotrienes (CysLTs), comprising LTC4, LTD4, and LTE4, are produced by immune cells during type 2 inflammation. Here, we uncover a role for LTC4 and its signaling through the CysLT receptor 2 (CysLT2R) in itch. Cysltr2 transcript is highly expressed in dorsal root ganglia (DRG) neurons linked to itch in mice. We also detected CYSLTR2 in a broad population of human DRG neurons. Injection of leukotriene C4 (LTC4) or its nonhydrolyzable form NMLTC4, but neither LTD4 nor LTE4, induced dose-dependent itch but not pain behaviors in mice. LTC4-mediated itch differed in bout duration and kinetics from pruritogens histamine, compound 48/80, and chloroquine. NMLTC4-induced itch was abrogated in mice deficient for Cysltr2 or when deficiency was restricted to radioresistant cells. Itch was unaffected in mice deficient for Cysltr1, Trpv1, or mast cells (WSh mice). CysLT2R played a role in itch in the MC903 mouse model of chronic itch and dermatitis, but not in models of dry skin or compound 48/80- or Alternaria-induced itch. In MC903-treated mice, CysLT levels increased in skin over time, and Cysltr2−/− mice showed decreased itch in the chronic phase of inflammation. Collectively, our study reveals that LTC4 acts through CysLT2R as its physiological receptor to induce itch, and CysLT2R contributes to itch in a model of dermatitis. Therefore, targeting CysLT signaling may be a promising approach to treat inflammatory itch.

scholarly journals CLINICAL AND DIAGNOSTIC VALUE OF DETERMINATION OF NEOPTERIN IN ATOPIC DERMATITIS IN CHILDREN

2018 ◽  
Vol 25 (3) ◽  
pp. 24-27
Author(s):  
M. M. BEN ◽  
E. YU. YANCHEVSKAYA ◽  
O. A. MESNYANKINA
Keyword(s):  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Secondary Infection ◽  
Clinical Manifestations ◽  
Diagnostic Value ◽  
Laboratory Method ◽  
Control Group ◽  
Allergic Skin ◽  
Monitoring And Forecasting

Aim. To improve the diagnosis of allergic skin diseases in childrenMaterials and methods. 135 children aged from 2 to 6 with atopic dermatitis were examined during exacerbation. They were on inpatient treatment in the skin and venereologic department of the Regional skin and venereologic dispensary and the Department of Allergology of the Regional children's clinical hospital. At the same time, 103 people (the main group) had uncomplicated course of the disease, 32 patients had complications of atopic dermatitis in the form of secondary infection. The control group consisted of 29 children aged 2 to 6. Neopterin in serum was determined by enzyme-linked immunosorbent analysis using test kits "Neopterin ELISA" (Germany). Statistical reliability of the obtained data was evaluated using The Student's test.Results. Atopic dermatitis in children, regardless of clinical manifestations, is accompanied by an increase in the content of neopterin in serum. The nature of the increase in the level of neopterin is determined by the duration of the disease, while its highest values are characteristic of the prolonged course of the process (over 4 years).Conclusion. The determination of neopterin in children with atopic dermatitis is a promising laboratory method for assessing the severity of dermatosis, monitoring and forecasting the further course of the process, as well as evaluating the effectiveness of therapeutic measures.

scholarly journals ALLERGIC SKIN DISEASES AND SPORT

2012 ◽  
Vol 9 (5) ◽  
pp. 17-25
Author(s):  
N V Shartanova ◽  
O G Elisyutina ◽  
E S Fedenko ◽  
N I Ilina
Keyword(s):  
Physical Activity ◽  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Elite Athletes ◽  
Skin Reactions ◽  
Immunological Mechanisms ◽  
Allergic Skin

According to various authors up to 25% of athletes suffer from allergies. In this review, we are talking about allergodermatoses. Various immunological mechanisms are underlying of skin reactions in elite athletes. Interesting facts about anaphylaxis, associated with physical activity and consumption of some food as well as about contact and atopic dermatitis are presented.

The prevalence of dogs with lymphocyte proliferative responses to food allergens in canine allergic dermatitis

2013 ◽  
Vol 16 (4) ◽  
pp. 735-739 ◽  
Author(s):  
K. Kawano ◽  
K. Oumi ◽  
Y. Ashida ◽  
Y. Horiuchi ◽  
T. Mizuno
Keyword(s):  
Atopic Dermatitis ◽  
Positive Result ◽  
Diagnostic Test ◽  
Skin Disease ◽  
Skin Diseases ◽  
Elimination Diet ◽  
Test Results ◽  
Food Allergens ◽  
Ige Antibodies ◽  
Allergic Skin

Abstract The aim of the present study was to examine the correlation between the results of lymphocyte proliferative test (LPT) specific to food allergens and allergic skin diseases in dogs. Investigations were performed in 138 dogs with allergic skin diseases diagnosed in a private animal hospital. Of the 138 animals, 97 cases had positive reactions in LPT specific to food allergens. Of these 97 dogs, 67 animals were diagnosed with canine atopic dermatitis (CAD), but 30 dogs did not have IgE antibodies to environmental allergens. As 14 dogs out of 30 animals showed a positive result, 12 dogs underwent elimination diet trial based on the test results and all of them showed improvement in the pruritus score. Therefore, we conclude that LPT is an effective diagnostic test for allergic skin disease. Results of the lymphocyte test are useful in the identification of food allergens for the elimination diet trial

scholarly journals THE EFFICIENCY OF LEVOCETIRIZINE IN TREATMENT OF ALLERGIC SKIN DISEASES

2012 ◽  
Vol 9 (5) ◽  
pp. 69-75
Author(s):  
O G Elisyutina ◽  
E S Fedenko ◽  
T G Fedoskova ◽  
L V Luss
Keyword(s):  
Atopic Dermatitis ◽  
Chronic Urticaria ◽  
Skin Diseases ◽  
Clinical Efficiency ◽  
Allergic Skin

In the article the results of supervision over the patients with chronic urticaria (n=32) and atopic dermatitis (n=30), at the age from 2 till 55 years old treated with H^blocker levocetirizine, are presented. High clinical efficiency and safety of levocetirizine treatment of allergic skin diseases were confirmed.

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