Stationary solution, extinction and density function for a high-dimensional stochastic SEI epidemic model with general distributed delay

2021 ◽  
Vol 405 ◽  
pp. 126236
Author(s):  
Bingtao Han ◽  
Baoquan Zhou ◽  
Daqing Jiang ◽  
Tasawar Hayat ◽  
Ahmed Alsaedi
2020 ◽  
Vol 133 ◽  
pp. 109643 ◽  
Author(s):  
Tomás Caraballo ◽  
Mohamed El Fatini ◽  
Mohamed El Khalifi ◽  
Richard Gerlach ◽  
Roger Pettersson

Mathematics ◽  
2020 ◽  
Vol 8 (11) ◽  
pp. 2000
Author(s):  
Domingo Benítez ◽  
Gustavo Montero ◽  
Eduardo Rodríguez ◽  
David Greiner ◽  
Albert Oliver ◽  
...  

A novel phenomenological epidemic model is proposed to characterize the state of infectious diseases and predict their behaviors. This model is given by a new stochastic partial differential equation that is derived from foundations of statistical physics. The analytical solution of this equation describes the spatio-temporal evolution of a Gaussian probability density function. Our proposal can be applied to several epidemic variables such as infected, deaths, or admitted-to-the-Intensive Care Unit (ICU). To measure model performance, we quantify the error of the model fit to real time-series datasets and generate forecasts for all the phases of the COVID-19, Ebola, and Zika epidemics. All parameters and model uncertainties are numerically quantified. The new model is compared with other phenomenological models such as Logistic Grow, Original, and Generalized Richards Growth models. When the models are used to describe epidemic trajectories that register infected individuals, this comparison shows that the median RMSE error and standard deviation of the residuals of the new model fit to the data are lower than the best of these growing models by, on average, 19.6% and 35.7%, respectively. Using three forecasting experiments for the COVID-19 outbreak, the median RMSE error and standard deviation of residuals are improved by the performance of our model, on average by 31.0% and 27.9%, respectively, concerning the best performance of the growth models.


2015 ◽  
Vol 08 (02) ◽  
pp. 1550027 ◽  
Author(s):  
Aadil Lahrouz

An epidemic model with a class of nonlinear incidence rates and distributed delay is analyzed. The nonlinear incidence is used to describe the saturated or the psychological effect of certain serious epidemics on the community when the number of infectives is getting larger. The distributed delay is derived to describe the dynamics of infectious diseases with varying immunity. Lyapunov functionals are used to show that the disease-free equilibrium state is globally asymptotically stable when the basic reproduction number is less than or equal to one. Moreover, it is shown that the disease is permanent if the basic reproduction number is greater than one. Furthermore, the sufficient conditions under which the endemic equilibrium is locally and globally asymptotically stable are obtained.


2018 ◽  
Author(s):  
Mingxu Hu ◽  
Hongkun Yu ◽  
Kai Gu ◽  
Kunpeng Wang ◽  
Siyuan Ren ◽  
...  

AbstractElectron cryo-microscopy (cryoEM) is now a powerful tool in determining atomic structures of biological macromolecules under nearly natural conditions. The major task of single-particle cryoEM is to estimate a set of parameters for each input particle image to reconstruct the three-dimensional structure of the macromolecules. As future large-scale applications require increasingly higher resolution and automation, robust high-dimensional parameter estimation algorithms need to be developed in the presence of various image qualities. In this paper, we introduced a particle-filter algorithm for cryoEM, which was a sequential Monte Carlo method for robust and fast high-dimensional parameter estimation. The cryoEM parameter estimation problem was described by a probability density function of the estimated parameters. The particle filter uses a set of random and weighted support points to represent such a probability density function. The statistical properties of the support points not only enhance the parameter estimation with self-adaptive accuracy but also provide the belief of estimated parameters, which is essential for the reconstruction phase. The implementation of these features showed strong tolerance to bad particles and enabled robust defocus refinement, demonstrated by the remarkable resolution improvement at the atomic level.


2019 ◽  
Vol 17 (03) ◽  
pp. 1850140 ◽  
Author(s):  
Aadil Lahrouz ◽  
Adel Settati ◽  
Mohamed El Fatini ◽  
Roger Pettersson ◽  
Regragui Taki

This paper is devoted to a continuous-time stochastic differential system which is derived by incorporating white noise to a deterministic [Formula: see text] epidemic model with mass action incidence, cure and relapse. We focus on the impact of a relapse on the asymptotic properties of the stochastic system. We show that the relapse encourages the persistence of the disease in the population and we determine the threshold of the relapse rate, above the threshold the disease prevails in the population. Furthermore, we show that there exists a unique density function of solutions which converges in [Formula: see text], under certain conditions of the parameters to an invariant density.


Author(s):  
N.V. Pertsev ◽  
B.Yu. Pichugin ◽  
A.N. Pichugina

Some results are presented of application of M-matrices to the study the stability problem of the equilibriums of differential equations used in models of living systems. The models studied are described by differential equations with several delays, including distributed delay, and by high-dimensional systems of differential equations. To study the stability of the equilibriums the linearization method is used. Emerging systems of linear differential equations have a specific structure of the right-hand parts, which allows to effectively use the properties of M-matrices. As examples, the results of studies of models arising in immunology, epidemiology and ecology are presented.


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