Physical parameters of neutrality in the work of an osteopathic physician

An osteopathic practitioner often meets the problem of physical fatigue, which is caused by a forced posture, excessive tension of the muscles of the trunk and arms, irrational biomechanical patterns of posture and movements, lack of support points, or switching points of mechanical energy of movement (fulcrum). These factors lead together to fatigue, which is felt as weariness and prevents the development of a pathophysiological state of overwork. Prevention of overwork by an osteopathic doctor can consist of a number of measures of labor organization and ergonomics, one of which is building a state of physical neutrality — a spatial position of the body that allows working with the patient as efficiently as possible and minimizing fatigue.

O APARELHO BUROCRÁTICO EDUCACIONAL: A ORGANIZAÇÃO DO ENSINO PARA O MUNDO DO TRABALHO

ResumoTomando como ponto de partida a noção de burocracia no campo do marxismo tem-se como tema central deste artigo a apresentação e análise da legislação educacional brasileira como forma de compreensão até mesmo do lugar da História neste cenário, além do entendimento do currículo desta disciplina no ensino básico. A hipótese que se pretende sustentar aponta para a centralidade das alterações constantes em benefício dos interesses das frações burguesas que têm influência no aparelho burocrático do Estado, neste caso, no aparelho burocrático educacional, sobretudo por meio da alteração da noção de planos de Estado para planos de governo.Palavras-Chave: Educação; Ensino de História; Burocracia; Legislação. AbstractTaking as a starting point the notion of bureaucracy in the Marxism, the central theme of this article is the presentation and analysis of Brazilian educational legislation as a way of understanding the place of history in this scenario, in addition for understanding the curriculum of this discipline in basic education. The hypothesis that we intend to support points to the centrality of the constant changes in favor of the interests of the bourgeois fractions that have an influence on the bureaucratic apparatus of the State, in this case, on the educational bureaucratic apparatus, mainly by changing the notion of State plans to plans of government.Key-Words: Education; History teaching; Bureaucracy; Legislation.

Cefepime precision dosing tool: From Standard to Precise Dose Using Nonparametric Population Pharmacokinetics

Cefepime is the second most common cephalosporin used in U.S. hospitals. We aim to develop and validate cefepime population pharmacokinetic (PK) model and integrate into precision dosing tool for implementation. Two datasets (680 patients) were used to build cefepime PK model in Pmetrics, and three datasets (34 patients) were used for the validation. A separate application dataset (115 patients) was used for the implementation and validation of a precision dosing tool. The model support points and covariates were used to generate the optimal initial dose (OID). Cefepime PK was described by a two-compartment model including weight and creatinine clearance (CrCl) as covariates. The median rate of elimination was 0.30 hr −1 (adults) and 0.96 hr −1 (pediatrics), central volume of distribution 13.85 L, and rate of transfer from the central to the peripheral compartments 1.22 hr −1 and from the peripheral to the central compartments 1.38 hr −1 . After integration in BestDose, the observed vs. predicted cefepime concentration fit using the application dataset was excellent (R 2 >0.98) and the median difference between observed and what BestDose predicted in a second occasion was 4%. For OID, cefepime 0.5-1g 4-hour infusion q8-24hr with CrCl<70 mL/min was needed to achieve a target range of free trough:MIC 1-4 at MIC 8 mg/L, while continuous infusion was needed for higher CrCl and weight values. In conclusion, we developed and validated a cefepime model for clinical application. The model was integrated in a precision dosing tool for implementation and the median concentration prediction bias was 4%. OID algorithm was provided.

CONSTRUÇÃO DE IMAGENS PANORÂMICAS EM MÚLTIPLAS FAIXAS DE ALTURA E LARGURA USANDO ALGORITMOS WATERSHED E GRAPH-CUT

In this work we developed an algorithm for building panoramas with multiple height and width ranges. For multilinear stitching, images were initially placed in a matrix and partial panoramas with images from the same column are generated. To complete the final panorama, the columns were divided with the help of support points and the neighboring columns were stitched, being reassembled at the end of the process. The stitching was performed with a graph cut algorithm in conjunction with the Watershed algorithm.

Impact of Different Components and Boundary Conditions on the Eigenfrequencies of a Magnet–Girder Assembly

Synchrotron radiation facilities are very important in different areas of fundamental and applied science to investigate structures or processes at small scales. Magnet–girder assemblies play a key role for the performance of such accelerator machines. High structural eigenfrequencies of the magnet–girder assemblies are required to assure a sufficient particle beam stability. The objective of the present parametric study was to numerically investigate and quantify the impact of different boundary conditions and components on the magnet–girder eigenfrequencies. As case studies, two 3 m long girder designs following the specifications of the PETRA IV project at DESY (German Electron Synchrotron, Hamburg, Germany) were selected. High magnet–girder assembly eigenfrequencies were achieved by, e.g., positioning the magnets close to the upper girder surface, increasing the connection stiffness between the magnets and the girder and between the girder and the bases, and positioning the girder support points as high as possible in the shape of a large triangle. Comparing the E/ρ ratio (E: Young’s modulus, ρ: material density) of different materials was used as a first approach to evaluate different materials for application to the girder. Based on the findings, general principles are recommended to be considered in the future girder design development processes.

Portolankarten – Aufnahme und Abbildung

Maps are flat images of the earth‘s surface. The basis and prerequisite for their production is the relative spatial definition of the map content on the earth‘s surface, and this is usually done in the context of surveying recording processes. The particular accuracy of the portolan charts, which have passed on since the thirteenth century, suggests that these were also created on the basis of specific measurements, although details of their creation have not yet been clarified. Questions about the data base and especially about the projection of the maps have been the subject of scientific research for over 100 years (Kretschmer 1909; Campbell 2021). Here, for the first time, a method is presented that makes it possible to construct maps of the Mediterranean with simple aids (compasses and ruler) in such a way that they correspond to the accuracy and other properties of the portolan charts. A map projection is used for which there are no mapping equations, but at most a mapping description. As a surveying basis for the mapping, distances are used that have been determined with a high degree of probability since ancient times. Triangles are constructed from these lines and transferred directly to the plane without any reduction in the image. The result is a geometrically unambiguous field of support points of known ports. The missing coastal structures can be supplemented after the construction of the field of support points on the basis of traditional coastal descriptions (Portolani/Periploi).

The Motor Impact of the Static Balance in the Up Plank Position on Three Different Balls in Physical Activities of Physical Education Students

The present study aimed to assess the capacity of stability and motor impact in the development of the balance of student athletes by reducing the support surface on the ball in the up plank position, by using three categories of balls of equal size, but with different elasticity and weight. In this study, the second aim was to investigate the differences in maintaining static balance, on different balls, between those who are practicing individual sports or team sports. The total study sample include 48 students, active athletes (45.8% of individual sports and 54.2% of team sports), age X ± SD 18.74 ± 1.94 years. The research included two test sessions (initial and final) applied in two stages. The static balance tests were performed by measuring the time maintaining the up plank position with two and three points of support on the three balls, with different characteristics of elasticity and ranges of deformation: medical ball, handball ball and fitness ball. The results of the study showed that the superior initial and final results were recorded on the fitness ball, and the inferior results on the medicine ball. The upper difference was recorded at the up plank position with two support points (arms, legs) on the fitness ball, at 4980 s, and the lowest in the same test on the medical ball, at 3420 s. The largest difference was recorded at the up plank position with three support points on the handball ball, at 7.082 s, and the lowest in the same test on the medical ball, at 3.093 s. The subjects of the study perceived that the most difficult position to execute was the up plank position on the medical ball with two support points, with 43.8%, and the easiest stability was registered in the up plank position on the fitness ball with three points of support, of 37.5%. The relevance of the research results from the possibility of using different balls in conditions of positioning and body posture with a diminished support base in order to improve physical fitness.

An Algorithm for Nonparametric Estimation of a Multivariate Mixing Distribution with Applications to Population Pharmacokinetics

Population pharmacokinetic (PK) modeling has become a cornerstone of drug development and optimal patient dosing. This approach offers great benefits for datasets with sparse sampling, such as in pediatric patients, and can describe between-patient variability. While most current algorithms assume normal or log-normal distributions for PK parameters, we present a mathematically consistent nonparametric maximum likelihood (NPML) method for estimating multivariate mixing distributions without any assumption about the shape of the distribution. This approach can handle distributions with any shape for all PK parameters. It is shown in convexity theory that the NPML estimator is discrete, meaning that it has finite number of points with nonzero probability. In fact, there are at most N points where N is the number of observed subjects. The original infinite NPML problem then becomes the finite dimensional problem of finding the location and probability of the support points. In the simplest case, each point essentially represents the set of PK parameters for one patient. The probability of the points is found by a primal-dual interior-point method; the location of the support points is found by an adaptive grid method. Our method is able to handle high-dimensional and complex multivariate mixture models. An important application is discussed for the problem of population pharmacokinetics and a nontrivial example is treated. Our algorithm has been successfully applied in hundreds of published pharmacometric studies. In addition to population pharmacokinetics, this research also applies to empirical Bayes estimation and many other areas of applied mathematics. Thereby, this approach presents an important addition to the pharmacometric toolbox for drug development and optimal patient dosing.