Impact of High-Density Lipoprotein Levels on Cardiovascular Outcomes of Patients Undergoing Percutaneous Coronary Intervention With Drug-Eluting Stents

2020 ◽  
Vol 137 ◽  
pp. 1-6
Author(s):  
Anastasios Roumeliotis ◽  
Bimmer Claessen ◽  
George Dangas ◽  
Rebecca Torguson ◽  
Samantha Sartori ◽  
...  
Keyword(s):  
Percutaneous Coronary Intervention ◽  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
Coronary Intervention ◽  
Cardiovascular Outcomes ◽  
High Density ◽  
Drug Eluting Stents ◽  
Percutaneous Coronary ◽  
Drug Eluting

Abstract 1692: The Impact of Hypertriglyceridemia on Clinical Outcome of Patients Subjected to Percutaneous Coronary Intervention in the Presence of High and Low High-Density Lipoprotein Cholesterol

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Rebecca Torguson ◽  
Kimberly Kaneshige ◽  
Zhenyi Xue ◽  
Petros Okubagzi ◽  
Augusto Pichard ◽  
...  
Keyword(s):  
Percutaneous Coronary Intervention ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
Coronary Intervention ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Cardiac Events ◽  
Percutaneous Coronary ◽  
Q Wave

Background: High-density lipoprotein cholesterol (HDLc) is known to have protective cardiovascular effects. Elevated triglycerides (TRI) are often targeted with therapeutic agents. This study aimed to investigate the effects of TRI in the presence of high and low levels of HDLc on clinical outcomes of patients undergoing contemporary percutaneous coronary intervention (PCI). Methods: We analyzed a series of 4391 patients who presented for elective contemporary PCI since 2003 and have completed 1-year clinical follow up. The study cohort comprised of 4 subgroups: high TRI with high HDLc, high TRI with low HDLc, normal TRI with high HDLc, and normal TRI with low HDLc. High TRI was defined as ≥ 200 mg/dl, normal TRI as < 200 mg/dl, high HDLc was defined as ≥ 40mg/dl for males and ≥ 45mg/dl for females, and low HDLc as < 40mg/dl for males and < 45mg/dl for females. The assessed endpoints, death, Q-wave myocardial infarction (Q wave MI), target vessel revascularization (TVR), and a composite of major adverse cardiac events (MACE) were then compared between groups. Results Approximately 98.1% of the overall population is on statin therapy. As expected, patients with high HDLc have significantly better outcomes as compared to those with low HDLc and normal TRI; however, the high TRI low HDLc group demonstrated similar outcomes to patients with high HDLc and normal TRI. Additionally, among the group with high TRI, there were no significant differences in 1-year MACE outcomes between tertiles of non-HDL cholesterol. (Table ) Conclusion: In patients undergoing PCI with normal triglycerides low HDLc was associated with increased MACE and death at 1 year when compared to high HDLc patients. In contrast, a similar incidence of death and MACE was observed in hypertriglycer-idemic patients with low HDLc and high HDLc levels. Therapies targeted to elevate HDLc among patients with normal TRI may play a critical role in the prevention of recurrent cardiac events post PCI. Table: 1 Year Outcomes

scholarly journals Correlation between monocyte to high-density lipoprotein ratio and major adverse cardiovascular events in patients with acute coronary syndrome after percutaneous coronary intervention

2021 ◽  
Vol 37 (3) ◽  
Author(s):  
Rong Yu ◽  
Ruigang Hou ◽  
Tong Wang ◽  
Tianliang Li ◽  
Huiyuan Han ◽  
...  
Keyword(s):  
Percutaneous Coronary Intervention ◽  
High Density Lipoprotein ◽  
Cardiovascular Events ◽  
Density Lipoprotein ◽  
Coronary Intervention ◽  
High Density ◽  
Major Adverse Cardiovascular Events ◽  
Gensini Score ◽  
Coronary Syndrome ◽  
Percutaneous Coronary

Objective: To investigate the correlation between monocyte to high-density lipoprotein ratio (MHR) and major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Methods: In this retrospective study, 120 ACS patients who received PCI in our hospital from September 2014 to August 2019 were selected and divided into MACE group and normal discharge (ND) group. Their clinical data were collected, and MHR values were compared. Logistic regression analysis was conducted to analyze the correlations between various factors and ACS. The correlation between MHR and Gensini score was subjected to Pearson’s analysis. Receiver operating characteristic (ROC) curve was plotted to analyze the diagnostic value of MHR for MACE. Results: Hypertension degree, white cell count, Gensini score, MHR and the levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDLC), high-density lipoprotein cholesterol (HDLC), apolipoprotein A1 (ApoA1), ApoB, lipoprotein (a) [LP(a)] and uric acid (UA) in MACE group were significantly higher than those in ND group (P<0.05). HDLC, ApoA1, TC, MHR, LDLC and ApoB were independent risk factors for MACE of ACS patients after PCI (P<0.05). There was a positive correlation between MHR and Gensini score (r=0.832, P<0.05), and the optimal cutoff value of MHR for diagnosing MACE was 9.45. Conclusion: Serum MHR is positively correlated with Gensini score in ACS patients after PCI, which can be used as an independent predictor for MACE in hospital. doi: https://doi.org/10.12669/pjms.37.3.3469 How to cite this:Yu R, Hou R, Wang T, Li T, Han H, An J. Correlation between monocyte to high-density lipoprotein ratio and major adverse cardiovascular events in patients with acute coronary syndrome after percutaneous coronary intervention. Pak J Med Sci. 2021;37(3):---------. doi: https://doi.org/10.12669/pjms.37.3.3469 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Percutaneous Coronary Intervention for Complex Bifurcation Lesions

2010 ◽  
Vol 5 (1) ◽  
pp. 58
Author(s):  
Yves Louvard ◽  
Morice Marie-Claude ◽  
Thomas Hovasse ◽  
Thierry Lefèvre ◽  
◽  
...  
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Coronary Intervention ◽  
Side Branch ◽  
Drug Eluting Stents ◽  
Open Angle ◽  
Balloon Inflation ◽  
Percutaneous Coronary ◽  
Drug Eluting ◽  
Bifurcation Lesions ◽  
Stent Diameter

Coronary bifurcations are prone to the development of atherosclerosis. They pose technical difficulties for angioplasty treatment and are a predictor of stent thrombosis and restenosis. Treatment of coronary bifurcations is still subject to debate, especially when the side branch (SB) is large, not easily accessible and narrowed by a long lesion. There is currently no indexed treatment for this type of lesion (Medina classification), as the strategy of provisional SB stenting with drug-eluting stents (DES) has proved to be equally efficient as the dualstent technique. Complex techniques are associated with poor outcome in certain lesion types, such as T-stenting when the angle between the two distal branches is small or the crush and culotte technique in the presence of an open angle. Provisional SB stenting may be used when primary dual stenting is required, with a low risk of failure provided that the following guidelines are implemented: stenting of the main branch through the protected SB with a stent diameter adapted to the distal main branch, immediate optimisation of the proximal stent segment (Finet’s law), guidewire exchange, kissing balloon inflation with non-compliant balloons selected according to the diameter of the distal branches and T-stenting of the SB before final kissing inflation.

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