Pilot Results of the Early Detection by Ultrasound of Carotid Artery Intima–Media Thickness Evaluation (EDUCATE) Study<subtitle />

Abstract Background Beta-thalassemia patients still suffer from many complications. Transfused patients may develop complications related to iron overload including growth retardation and failure or delay of sexual maturation, cardiac involvement (dilated cardiomyopathy or rarely arrhythmia), liver (fibrosis and cirrhosis), endocrine glands (diabetes mellitus, hypogonadism, insufficiency of parathyroid, thyroid, pituitary and less commonly, adrenal glands). Purpose The present study was undertaken to evaluate the role of Carotid artery intima media thickness (CIMT) measurement as an early detector of premature atherosclerosis in beta-thalassemia children and early adolescents and its relation to biochemical risk factors as iron overload and lipid profile. Patients and Method Twenty-two β-thalassemia major (TM), 8 β-thalassemia intermedia (TI) with confirmed diagnosis of beta-thalassemia (major and intermedia) proved by clinical and laboratory investigations, frequent blood transfusion, chelation therapy with their age ranging from 10 to18 years old and 30 age-and sex matched healthy controls were included. Lipid profile (by colorimetric assay), serum ferritin, and CIMT measurements using high-resolution B-mode ultrasonography were estimated. Results CIMT of thalassemic patients (major and intermedia) was highly significantly increased compared to controls with no significant difference between β-thalassemia major and β thalassemia intermedia groups could be detected. CIMT was positively correlated with serum ferritin, TG, Total cholesterol level in both diseased groups and LDL level in B-TM group only. This provides a good evidence of the presence of premature atherosclerosis in vascular-free TM and TI patients and its relation to increased body iron and dyslipidemia. Conclusion Carotid artery intima media thickness represented a simple, accurate and non-invasive method for early detection of premature atherosclerosis which started early in β- thalassemia patients This study identified a relationship between body iron status, dyslipidemia and increased carotid IMT..

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Age, gender and hypertension as major risk factors in development of subclinical atherosclerosis

Journal of Health Sciences ◽

10.17532/jhsci.2013.24 ◽

2013 ◽

Vol 3 (1) ◽

pp. 26-29

Author(s):

Ajla Rahimić Ćatić ◽

Sandra Vegar Zubović ◽

Jasminka Ðelilović Vranić ◽

Svjetlana Lozo

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Carotid Artery ◽

Early Detection ◽

Common Carotid Artery ◽

Carotid Atherosclerosis ◽

Heart Diseases ◽

Subclinical Atherosclerosis ◽

Intima Media Thickness ◽

Media Thickness

Introduction: Intima-media thickness (IMT) measurement of the common carotid artery (CCA) is considered as useful indicator of carotid atherosclerosis. Early detection of atherosclerosis and its associated risk factors is important to prevent stroke and heart diseases. The aim of the present study was to investigate which risk factors are better determinants of subclinical atherosclerosis, measured by common carotidartery intima media thickness (CCA-IMT).Methods: A total of 74 subjects were randomly selected in this cross – sectional study. Information on the patient’s medical history and laboratory fi ndings were obtained from their clinical records. Risk factors relevant to this study were age, gender, cigarette smoking status, diabetes, hypertension and dyslipidemia. Ultrasound scanning of carotid arteries was performed with a 7,5 MHz linear array transducer (GE Voluson730 pro). The highest value of six common carotid artery measurements was taken as the fi nal IMT. Increased CCA-IMT was defi ned when it was > 1 mm.Results: Our data demonstrated higher CCA-IMT values in male patients compared with female patients. Increased CCA-IMT was the most closely related to age (P<0.001), followed by systolic blood pressure (P=0.001), diastolic blood pressure (P=0.003) and glucose blood level (P=0.048).Conclusion: Age, gender and hypertension are the most important risk factors in development of carotid atherosclerosis. Early detection of atherosclerosis among high-risk populations is important in order to prevent stroke and heart diseases, which are leading causes of death worldwide.

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911 Carotid artery intima-media thickness evaluation during a routine transthoracic echocardiogram. Methods and feasibility

European Journal of Echocardiography ◽

10.1016/s1525-2167(05)80521-9 ◽

2005 ◽

Vol 6 ◽

pp. S140-S140

Keyword(s):

Carotid Artery ◽

Intima Media Thickness ◽

Transthoracic Echocardiogram ◽

Media Thickness ◽

Thickness Evaluation

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Intima-media thickness measurement of the carotid artery in patients with primary hyperparathyroidism

Endocrine Abstracts ◽

10.1530/endoabs.37.ep617 ◽

2015 ◽

Author(s):

Dilek Tuzun ◽

Ayten Oguz ◽

Murat Sahin ◽

Safa Ersen Ganidagli ◽

Didem Atay ◽

...

Keyword(s):

Carotid Artery ◽

Primary Hyperparathyroidism ◽

Intima Media Thickness ◽

Thickness Measurement ◽

Media Thickness

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QT Intervals Correlate with Carotid Artery Intima Media Thickness in a Gender-Specific and Segment-Specific Manner in Asymptomatic Dyslipidemic Patients

Cardiology & Neurocardiovascular Diseases ◽

10.24966/cncd-8860/100005 ◽

2015 ◽

Vol 2 (1) ◽

pp. 1-5

Author(s):

Giuliana Mombelli ◽

Keyword(s):

Carotid Artery ◽

Intima Media Thickness ◽

Media Thickness ◽

Qt Intervals ◽

Specific Manner ◽

Gender Specific

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Application of the Measurement of Carotid Intima-Media Thickness for Prediction of the Essential Hypertension in Children

Revista de Chimie ◽

10.37358/rc.18.6.6366 ◽

2018 ◽

Vol 69 (6) ◽

pp. 1550-1553

Author(s):

Rosana Manea ◽

Bianca Elena Popovici ◽

Carmen Daniela Neculoiu ◽

Dan Minea ◽

Alina Calin

Keyword(s):

Blood Pressure ◽

Essential Hypertension ◽

Carotid Artery ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Diagnostic Methods ◽

Control Group ◽

Study Group ◽

Media Thickness ◽

Hypertension In Children

Hypertension is a major risk factor for progression of the atherosclerotic process and for developing of degenerative cardiovascular diseases in adulthood. The aim of this study is to evaluate how the measurement of carotid intima - media thickness for prediction of essential hypertension in children can be used.The study group included 81 children and the control group 61 children, all aged between 5 - 17 years and 11 months old, and admitted in Children Hospital Brasov in the period of 2009 � 2014. The study protocol included: BMI, blood pressure and Doppler echography of the common carotid artery for each group. Mean age of the patients from the study group was 13.67 years, 43.20 % girls and 56.80 % boys, while in the control group, the mean age was 14.07 years, 54.10% girls and 45.90 % boys. 70.37% of the children from the study group presented obesity, while in the control group 40.98% were obese. The IMTC study group ranged from 0.52 - 0.69 mm and the limits of the normotensive subjects were 0.32 -0.54 mm. In both groups the obese patients were found to have increased carotid artery intima-media, which means that IMTC was positively correlated with BMI (p=0.000001).It is necessary to identify diagnostic methods easily applicable for children, allowing involvement of the characteristics of the arterial wall in the degenerative pathological processes. Increased intima-media ratio is positively correlated with high values of blood pressure.

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