Anticoagulation influences long-term outcome in patients with nonvalvular atrial fibrillation and severe ischemic stroke

2004 ◽  
Vol 2 (4) ◽  
pp. 265-273 ◽  
Author(s):  
Konstantinos N. Vemmos ◽  
Georgios Tsivgoulis ◽  
Konstantinos Spengos ◽  
Efstathios Manios ◽  
Savas Toumanidis ◽  
...  

2019 ◽  
Vol 8 (11) ◽  
pp. 1897 ◽  
Author(s):  
Hyungjong Park ◽  
Minho Han ◽  
Young Dae Kim ◽  
Joonsang Yoo ◽  
Hye Sun Lee ◽  
...  

Background: Atrial fibrillation (AF) shares several risk factors with atherosclerosis. We investigated the association between total carotid plaque number (TPN) and long-term prognosis in ischemic stroke patients with AF. Methods: A total of 392 ischemic stroke patients with AF who underwent carotid ultrasonography were enrolled. TPN was assessed using B-mode ultrasound. The patients were categorized into two groups according to best cutoff values for TPN (TPN ≤ 4 vs. TPN ≥ 5). The long-term risk of major adverse cardiovascular events (MACE) and mortality according to TPN was investigated using a Cox hazard model. Results: After a mean follow-up of 2.42 years, 113 patients (28.8%) had developed MACE and 88 patients (22.4%) had died. MACE occurred more frequently in the TPN ≥ 5 group than in the TPN ≤ 4 group (adjusted hazard ratio [HR], 1.50; 95% confidence interval [CI], 1.01–2.21; p < 0.05). Moreover, the TPN ≥ 5 group showed an increased risk of all-cause mortality (adjusted HR, 2.69; 95% CI, 1.40–5.17; p < 0.05). TPN along with maximal plaque thickness and intima media thickness showed improved prognostic utility when added to the variables of the CHAD2DS2-VASc score. Conclusion: TPN can predict the long-term outcome of ischemic stroke patients with AF. Adding TPN to the CHAD2DS2-VASc score increases the predictability of outcome after stroke.



2011 ◽  
Vol 22 ◽  
pp. S68-S69
Author(s):  
George Ntaios ◽  
Anastasia Vemmou ◽  
Eleni Koromboki ◽  
Paraskevi Savvari ◽  
Michalis Saliaris ◽  
...  


Author(s):  
Marcio José Montenegro da Costa ◽  
Esmeralci Ferreira ◽  
Edgard Freitas Quintella ◽  
Bernardo Amorim ◽  
Alexandre Fuchs ◽  
...  


2012 ◽  
Vol 8 (4) ◽  
pp. 251 ◽  
Author(s):  
Dohoung Kim ◽  
Jong-Won Chung ◽  
Chi Kyung Kim ◽  
Wi-Sun Ryu ◽  
Eun-Sun Park ◽  
...  


2013 ◽  
Vol 167 (4) ◽  
pp. 1519-1523 ◽  
Author(s):  
G. Ntaios ◽  
A. Vemmou ◽  
E. Koroboki ◽  
P. Savvari ◽  
K. Makaritsis ◽  
...  


2008 ◽  
Vol 56 (S 1) ◽  
Author(s):  
M Fritz ◽  
K Khargi ◽  
D Voss ◽  
T Lawo ◽  
A Mügge ◽  
...  


2021 ◽  
pp. 239698732110195
Author(s):  
P Correia ◽  
S Machado ◽  
I Meyer ◽  
M Amiguet ◽  
A Eskandari ◽  
...  

Introduction Systemic contraceptives increase the risk of ischemic stroke but little is known about the characteristics, mechanisms and long-term outcome post stroke of patients on hormonal contraception. We sought to To assess characteristics and outcome of acute ischemic stroke (AIS) in young women using systemic hormonal contraceptives (SHC) and compare them to strokes in non-contraceptive users. Patients and methods Using the Acute STroke Registry and Analysis of Lausanne (ASTRAL), we analyzed demographics, risk factors, clinical, radiological and treatment data of consecutive female patients of <50 years between 2003 to 2015. We compared groups with and without SHC in a logistic regression analysis. Results Of the 179 female patients of <50 years during the observation period, 57 (39.6%) used SHC, 71.9% of whom, a combined oral contraceptive pill. On logistic regression contraceptive users were significantly younger but had comparable stroke severity. They had less migraine with aura and tobacco use, and more hyperlipidaemia. Also, contraceptive users had significantly less intra and extracranial stenosis and occlusion on arterial imaging, but more focal hypoperfusion on CT-perfusion. Undetermined mechanism of stroke was more frequent with SHC users, whereas rare mechanisms were more frequent in non-users. The contraceptive user group had a more favourable adjusted 12-month outcome with significantly fewer ischemic recurrences after stopping systemic contraception in all. Conclusion Contraceptive users with ischemic strokes are younger and have lesser tobacco use and migraine with aura and more hyperlipidemia. Their stroke mechanism is more often undetermined using a standardised work-up, and their adjusted long-term outcome is more favourable with less stroke recurrence.



EP Europace ◽  
2003 ◽  
Vol 4 (Supplement_2) ◽  
pp. B130-B130
Author(s):  
H. Mlcochova ◽  
R. Cihak ◽  
J. Kautzner ◽  
J. Bytesnik ◽  
V. Vancura ◽  
...  




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