Vitamin D deficiency are associated with subjective disease severity in Chinese patients with chronic rhinosinusitis with nasal polyps

2019 ◽  
Vol 40 (1) ◽  
pp. 36-39 ◽  
Author(s):  
Feng Wang ◽  
Yang Yang ◽  
Haihong Chen
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Chronic Rhinosinusitis ◽  
Disease Severity ◽  
Nasal Polyps ◽  
Chinese Patients

scholarly journals Vitamin D deficiency is associated with increased human sinonasal fibroblast proliferation in chronic rhinosinusitis with nasal polyps

2016 ◽  
Vol 6 (6) ◽  
pp. 605-610 ◽  
Author(s):  
William W. Carroll ◽  
Rodney J. Schlosser ◽  
Brendan P. O'Connell ◽  
Zachary M. Soler ◽  
Jennifer K. Mulligan
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Fibroblast Proliferation

scholarly journals JAK2 Phosphorylation Signals and Their Associated Cytokines Involved in Chronic Rhinosinusitis with Nasal Polyps and Correlated with Disease Severity

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1059
Author(s):  
Yu-Tsai Lin ◽  
Wei-Chih Chen ◽  
Ming-Hsien Tsai ◽  
Jing-Ying Chen ◽  
Chih-Yen Chien ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Disease Severity ◽  
Nasal Polyps ◽  
Inflammatory Diseases ◽  
Janus Kinase ◽  
Sinus Surgery ◽  
Control Group ◽  
Jak2 Inhibitor ◽  
Ifn Γ ◽  
Snot 22

Janus kinase 2 (JAK2) is a member of the JAK family that transduces cytokine-mediated signals via the JAKs/STATs (signal transducer and activator of transcription proteins) pathway, which plays an important role in many inflammatory diseases. This study investigates the association of p-JAK2 and JAK2-associated cytokines from nasal polyp (NP) tissue with disease severity, and evaluates the p-JAK2-mediated STATs in chronic rhinosinusitis (CRS) with NP. Sixty-one CRSwNP patients with nasal polyps undergoing endoscopic sinus surgery were enrolled, while the turbinate tissues from 26 nasal obstruction patients were examined as the control group. Elevated levels of p-JAK2 were detected in CRSwNP, and significantly correlated with scores of disease severity (LMK-CT, TPS, and SNOT-22). Expressions of the JAK2-associated cytokines, such as IL-5, IL-6, IL-13, G-CSF, and IFN-γ were significantly higher in CRSwNP than in the controls, while the levels of IL-5, IL-6, IL-13, or G-CSF had positive correlation with scores of disease severity. Moreover, markedly increased expression of p-STAT3 in CRSwNP was observed relative to the control. Taken together, these data showed that the JAK2-associated cytokines including IL-6 and G-CSF may stimulate JAK2 phosphorylation to activate p-STAT3, indicating an association with disease severity and supporting its development of JAK2 inhibitor as a potential therapeutic agent for CRS.

Vitamin D deficiency in adult patients with ulcerative colitis: Prevalence and relationship with disease severity, extent, and duration

2019 ◽  
Vol 38 (1) ◽  
pp. 6-14 ◽  
Author(s):  
Arjun Datt Law ◽  
Usha Dutta ◽  
Rakesh Kochhar ◽  
Chetana Vaishnavi ◽  
Shiva Kumar ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Disease Severity ◽  
Adult Patients

scholarly journals Prevalence of vitamin D deficiency in Chinese patients with early stage colorectal cancer

2018 ◽  
Vol 29 ◽  
pp. ix41
Author(s):  
D. Ng ◽  
R. Tan ◽  
R. Sultana ◽  
M. Ang ◽  
W. Lim ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Early Stage ◽  
Chinese Patients

The prevalence of vitamin D deficiency and its relationship with disease severity in an urban pediatric critical care unit

2014 ◽  
Vol 48 (02) ◽  
pp. 69-76 ◽  
Author(s):  
M. Ayulo Jr. ◽  
Ch. Katyal ◽  
Ch. Agarwal ◽  
T. Sweberg ◽  
D. Rastogi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Critical Care ◽  
Vitamin D Deficiency ◽  
Disease Severity ◽  
Critical Care Unit ◽  
Pediatric Critical Care

scholarly journals Vitamin D deficiency: prevalence and association with liver disease severity in pediatric nonalcoholic fatty liver disease

2019 ◽  
Vol 74 (3) ◽  
pp. 427-435 ◽  
Author(s):  
Toshifumi Yodoshi ◽  
Sarah Orkin ◽  
Ana Catalina Arce-Clachar ◽  
Kristin Bramlage ◽  
Chunyan Liu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Vitamin D Deficiency ◽  
Disease Severity ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver

Fibroblast levels are increased in chronic rhinosinusitis with nasal polyps and are associated with worse subjective disease severity

2015 ◽  
Vol 6 (2) ◽  
pp. 162-168 ◽  
Author(s):  
William W. Carroll ◽  
Brendan P. O'Connell ◽  
Rodney J. Schlosser ◽  
David A. Gudis ◽  
Tom T. Karnezis ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Disease Severity ◽  
Nasal Polyps
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