The diagnostic and prognostic value of tumor markers in giant mediastinal endodermal sinus tumor with prolonged survival: Twelve-year follow up after radical resection

Abstract A case of embryonal carcinoma in the pineal region of a 17-year-old boy is presented. The tumor included elements of choriocarcinoma and endodermal sinus tumor, and the use of human chorionic gonadotropin and alpha-fetoprotein as tumor markers is discussed. The markers were demonstrated both within the tumor and in the cerebrospinal fluid (CSF) and blood. The patient was treated with a postoperative program of irradiation and cancer chemotherapy, and at follow-up examination 20 months after operation no signs of residual tumor were present. It is suggested that human chorionic gonadotropin and alpha-fetoprotein should be measured in the blood and CSF before the treatment of midline tumors.

Download Full-text

Endodermal Sinus Tumor of the Parotid Gland in a Child

Pediatric and Developmental Pathology ◽

10.1007/s10024-003-4048-8 ◽

2004 ◽

Vol 7 (1) ◽

pp. 77-80 ◽

Cited By ~ 8

Author(s):

Simone Treiger Sredni ◽

Isabela Werneck da Cunha ◽

Nevigolino Pereira de Carvalho Filho ◽

José Magrin ◽

Clovis Antonio Lopes Pinto ◽

...

Keyword(s):

Parotid Gland ◽

Elevated Serum ◽

Alpha Fetoprotein ◽

Endodermal Sinus Tumor ◽

Cervical Tumor ◽

Serum Alpha Fetoprotein ◽

Sinus Tumor ◽

Gross Examination

We report a case of a 16-month-old girl with a primary endodermal sinus tumor (EST) of the parotid gland. The girl was admitted to the hospital with a left side cervical tumor with a quick growth (within 3 wk). The tumor was surgically resected. The gross examination showed a 7.0-cm hemorrhagic and fragmentized mass. Diagnosis of an EST was established on the hematoxylin and eosinstained slides from the resected material. Elevated serum alpha-fetoprotein (AFP) levels were detected and follow-up examinations of the patient did not show ESTs in other locations or other manifestations due to the tumor. The patient received chemotherapy after the surgery and remained alive without evidence of disease at the time of this writing (2 years after the diagnosis). As far as we know, this is the second report in the literature of a parotid gland's EST.

Download Full-text

Diagnostic and prognostic value of interleukin-6, pentraxin 3, and procalcitonin levels among sepsis and septic shock patients: a prospective controlled study according to the Sepsis-3 definitions

10.21203/rs.2.13144/v3 ◽

2019 ◽

Author(s):

Juhyun Song ◽

Dae Won Park ◽

Sungwoo Moon ◽

Han-Jin Cho ◽

Jong Hak Park ◽

...

Keyword(s):

Septic Shock ◽

Interleukin 6 ◽

Prognostic Value ◽

Controlled Study ◽

Pentraxin 3 ◽

Clinical Value ◽

International Consensus ◽

Sepsis And Septic Shock ◽

Diagnostic And Prognostic Value

Abstract Background: This study investigated the clinical value of interleukin-6 (IL-6), pentraxin 3 (PTX3), and procalcitonin (PCT) in patients with sepsis and septic shock diagnosed according to the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). Methods: Serum levels of IL-6, PTX3, and PCT were measured in 142 enrolled subjects (51 with sepsis, 46 with septic shock, and 45 as controls). Follow-up IL-6 and PTX3 levels were measured in patients with initial septic shock within 24 hours of hospital discharge. Optimal cut-off values were determined for sepsis and septic shock, and prognostic values were evaluated. Results: Serum IL-6 levels could discriminate sepsis (area under the curve [AUC], 0.83–0.94, P < 0.001; cut-off value, 52.60 pg/mL, 80.4% sensitivity, 88.9% specificity) from controls and could distinguish septic shock (AUC, 0.71-0.89; cut-off value, 348.92 pg/mL, 76.1% sensitivity, 78.4% specificity) from sepsis. Twenty-eight-day mortality was significantly higher in the group with high IL-6 (≥ 348.92 pg/mL) than in the group with low IL-6 (< 348.92 pg/mL) (P = 0.008). IL-6 was an independent risk factor for 28-day mortality among overall patients (hazard ratio, 1.0004; 95% confidence interval, 1.0003–1.0005; p = 0.024). In septic shock patients, both the initial and follow-up PTX3 levels were consistently significantly higher in patients who died than in those who recovered (initial p = 0.004; follow-up P < 0.001). Conclusions: The diagnostic and prognostic value of IL-6 was superior to those of PTX3 and PCT for sepsis and septic shock.

Download Full-text

Diagnostic and prognostic value of interleukin-6, pentraxin 3, and procalcitonin levels among sepsis and septic shock patients: a prospective controlled study according to the Sepsis-3 definitions

10.21203/rs.2.13144/v4 ◽

2019 ◽

Author(s):

Juhyun Song ◽

Dae Won Park ◽

Sungwoo Moon ◽

Han-Jin Cho ◽

Jong Hak Park ◽

...

Keyword(s):

Septic Shock ◽

Interleukin 6 ◽

Prognostic Value ◽

Controlled Study ◽

Pentraxin 3 ◽

Clinical Value ◽

International Consensus ◽

Sepsis And Septic Shock ◽

Diagnostic And Prognostic Value

Abstract Background: This study investigated the clinical value of interleukin-6 (IL-6), pentraxin 3 (PTX3), and procalcitonin (PCT) in patients with sepsis and septic shock diagnosed according to the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). Methods: Serum levels of IL-6, PTX3, and PCT were measured in 142 enrolled subjects (51 with sepsis, 46 with septic shock, and 45 as controls). Follow-up IL-6 and PTX3 levels were measured in patients with initial septic shock within 24 hours of hospital discharge. Optimal cut-off values were determined for sepsis and septic shock, and prognostic values were evaluated. Results: Serum IL-6 levels could discriminate sepsis (area under the curve [AUC], 0.83–0.94, P < 0.001; cut-off value, 52.60 pg/mL, 80.4% sensitivity, 88.9% specificity) from controls and could distinguish septic shock (AUC, 0.71-0.89; cut-off value, 348.92 pg/mL, 76.1% sensitivity, 78.4% specificity) from sepsis. Twenty-eight-day mortality was significantly higher in the group with high IL-6 (≥ 348.92 pg/mL) than in the group with low IL-6 (< 348.92 pg/mL) (P = 0.008). IL-6 was an independent risk factor for 28-day mortality among overall patients (hazard ratio, 1.0004; 95% confidence interval, 1.0003–1.0005; p = 0.024). In septic shock patients, both the initial and follow-up PTX3 levels were consistently significantly higher in patients who died than in those who recovered (initial p = 0.004; follow-up P < 0.001). Conclusions: The diagnostic and prognostic value of IL-6 was superior to those of PTX3 and PCT for sepsis and septic shock.

Download Full-text

Diagnostic and prognostic value of interleukin-6, pentraxin 3, and procalcitonin levels among sepsis and septic shock patients: a prospective controlled study according to the Sepsis-3 definitions

BMC Infectious Diseases ◽

10.1186/s12879-019-4618-7 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 18

Author(s):

Juhyun Song ◽

Dae Won Park ◽

Sungwoo Moon ◽

Han-Jin Cho ◽

Jong Hak Park ◽

...

Keyword(s):

Septic Shock ◽

Interleukin 6 ◽

Prognostic Value ◽

Controlled Study ◽

Pentraxin 3 ◽

Clinical Value ◽

International Consensus ◽

Sepsis And Septic Shock ◽

Diagnostic And Prognostic Value

Abstract Background This study investigated the clinical value of interleukin-6 (IL-6), pentraxin 3 (PTX3), and procalcitonin (PCT) in patients with sepsis and septic shock diagnosed according to the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). Methods Serum levels of IL-6, PTX3, and PCT were measured in 142 enrolled subjects (51 with sepsis, 46 with septic shock, and 45 as controls). Follow-up IL-6 and PTX3 levels were measured in patients with initial septic shock within 24 h of hospital discharge. Optimal cut-off values were determined for sepsis and septic shock, and prognostic values were evaluated. Results Serum IL-6 levels could discriminate sepsis (area under the curve [AUC], 0.83–0.94, P < 0.001; cut-off value, 52.60 pg/mL, 80.4% sensitivity, 88.9% specificity) from controls and could distinguish septic shock (AUC, 0.71–0.89; cut-off value, 348.92 pg/mL, 76.1% sensitivity, 78.4% specificity) from sepsis. Twenty-eight-day mortality was significantly higher in the group with high IL-6 (≥ 348.92 pg/mL) than in the group with low IL-6 (< 348.92 pg/mL) (P = 0.008). IL-6 was an independent risk factor for 28-day mortality among overall patients (hazard ratio, 1.0004; 95% confidence interval, 1.0003–1.0005; p = 0.024). In septic shock patients, both the initial and follow-up PTX3 levels were consistently significantly higher in patients who died than in those who recovered (initial p = 0.004; follow-up P < 0.001). Conclusions The diagnostic and prognostic value of IL-6 was superior to those of PTX3 and PCT for sepsis and septic shock.

Download Full-text

Diagnostic and prognostic value of interleukin-6, pentraxin 3, and procalcitonin levels among sepsis and septic shock patients: a prospective controlled study according to the Sepsis-3 definitions

10.21203/rs.2.13144/v2 ◽

2019 ◽

Author(s):

Juhyun Song ◽

Dae Won Park ◽

Sungwoo Moon ◽

Han-Jin Cho ◽

Jong Hak Park ◽

...

Keyword(s):

Septic Shock ◽

Interleukin 6 ◽

Prognostic Value ◽

Controlled Study ◽

Pentraxin 3 ◽

Clinical Value ◽

International Consensus ◽

Sepsis And Septic Shock ◽

Diagnostic And Prognostic Value

Abstract Background: This study investigated the clinical value of interleukin-6 (IL-6), pentraxin 3 (PTX3), and procalcitonin (PCT) in patients with sepsis and septic shock diagnosed according to the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). Methods: Serum levels of IL-6, PTX3, and PCT were measured in 142 enrolled subjects (51 with sepsis, 46 with septic shock, and 45 as controls). Follow-up IL-6 and PTX3 levels were measured in patients with initial septic shock within 24 hours of hospital discharge. Optimal cut-off values were determined for sepsis and septic shock, and prognostic values were evaluated. Results: Serum IL-6 levels could discriminate sepsis (area under the curve [AUC], 0.83–0.94, P < 0.001; cut-off value, 52.60 pg/mL, 80.4% sensitivity, 88.9% specificity) from controls and could distinguish septic shock (AUC, 0.71-0.89; cut-off value, 348.92 pg/mL, 76.1% sensitivity, 78.4% specificity) from sepsis. Twenty-eight-day mortality was significantly higher in the group with high IL-6 (≥ 348.92 pg/mL) than in the group with low IL-6 (< 348.92 pg/mL) (P = 0.008). IL-6 was an independent risk factor for 28-day mortality among overall patients (hazard ratio, 1.0004; 95% confidence interval, 1.0003–1.0005; p = 0.024). In septic shock patients, both the initial and follow-up PTX3 levels were consistently significantly higher in patients who died than in those who recovered (initial p = 0.004; follow-up P < 0.001). Conclusions: The diagnostic and prognostic value of IL-6 was superior to those of PTX3 and PCT for sepsis and septic shock.

Download Full-text

Diagnostic and prognostic value of interleukin-6, pentraxin 3, and procalcitonin levels among sepsis and septic shock patients: a prospective controlled study according to the Sepsis-3 definitions

10.21203/rs.2.13144/v1 ◽

2019 ◽

Author(s):

Juhyun Song ◽

Dae won Park ◽

Sungwoo Moon ◽

Han-Jin Cho ◽

Jong Hak Park ◽

...

Keyword(s):

Septic Shock ◽

Interleukin 6 ◽

Prognostic Value ◽

Controlled Study ◽

Pentraxin 3 ◽

Clinical Value ◽

International Consensus ◽

Sepsis And Septic Shock ◽

Diagnostic And Prognostic Value

Abstract Background This study investigated the clinical value of interleukin-6 (IL-6), pentraxin 3 (PTX3), and procalcitonin (PCT) in patients with sepsis and septic shock diagnosed according to the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).Methods Serum levels of IL-6, PTX3, and PCT were measured in 143 enrolled subjects (51 with sepsis, 46 with septic shock, and 46 controls). Follow-up IL-6 and PTX3 levels were measured in patients with initial septic shock within 24 hours of hospital discharge. Optimal cut-off values were determined for sepsis and septic shock, and prognostic values were evaluated.Results Serum IL-6 levels could discriminate sepsis (area under the curve [AUC], 0.97–1.00, P < 0.001; cut-off value, 5.89 pg/mL, 97.0% sensitivity, 97.2% specificity) from controls and could distinguish septic shock (AUC, 0.85-0.95; cut-off value, 53.59 pg/mL, 91.8% sensitivity, 63.2% specificity) from both sepsis and controls. Twenty-eight-day mortality was significantly higher in the group with high IL-6 (≥ 53.59 pg/mL) than with low IL-6 (< 53.59 pg/mL) (P = 0.002). IL-6 was an independent risk factor for 28-day mortality among patients overall (hazard ratio, 1.0004; 95% confidence interval, 1.0003–1.0005; p = 0.024). In septic shock patients, both initial and follow-up PTX3 levels were consistently significantly higher in patients who died than in those who recovered (initial p = 0.004; follow-up P < 0.001).Conclusions The diagnostic and prognostic value of IL-6 was superior to those of PTX3 and PCT for sepsis and septic shock.

Download Full-text

Diagnostic and prognostic value of bone biomarkers in progressive knee osteoarthritis: a 6-year follow-up study in middle-aged subjects

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2013.03.008 ◽

2013 ◽

Vol 21 (6) ◽

pp. 815-822 ◽

Cited By ~ 20

Author(s):

J. Kumm ◽

A. Tamm ◽

M. Lintrop ◽

A. Tamm

Keyword(s):

Knee Osteoarthritis ◽

Prognostic Value ◽

Bone Biomarkers ◽

Middle Aged ◽

Follow Up Study ◽

Aged Subjects ◽

Diagnostic And Prognostic Value

Download Full-text

Clinical Characteristics and Risk Factors Analysis for the Recurrence of Pelvic Endodermal Sinus Tumors

10.21203/rs.3.rs-1079415/v1 ◽

2021 ◽

Author(s):

Yanglong Guo ◽

Xi Chen ◽

Qingqing Lin ◽

Tao Zhu ◽

Ying-Li Zhang

Keyword(s):

Initial Treatment ◽

Embryonal Carcinoma ◽

Progression Free Survival ◽

Residual Tumor ◽

Endodermal Sinus Tumor ◽

Initial Management ◽

Free Survival ◽

Platinum Based Chemotherapy ◽

Sinus Tumor

Abstract Background: This study investigated the clinicopathological characteristics and factors influencing the recurrence of pelvic endodermal sinus tumor. Methods: Fifty-four cases were retrospectively analyzed from at the Zhejiang Cancer Hospital. Imaging and serological indicators were used to determine whether disease recurred, to evaluate progression-free survival, and to compare the influence of related factors on disease recurrence. SPSS 19.0 software was used for statistical analysis. Statistical significance was defined as p < 0.05. Results: The median age at initial treatment was 21 years (range, 11–52 years). Six patients had extragonadal endodermal sinus tumor, and four had histological features of endodermal sinus tumor combined with embryonal carcinoma. Thirty-nine patients underwent fertility-preserving surgery, 18 patients had a childbearing history, and eight patients had residual tumor after initial treatment. Twenty-six patients had a tumor diameter of more than 15 cm, and 30 patients had a serum α‑fetoprotein level greater than 10,000 ng/mL before initial management. The median follow-up time was 47.5 months (range, 14–212 months). During follow-up, 15 patients experience recurrence, with a recurrence rate of 27.8% and a 5-year PFS rate of 61.1%. In univariate analysis, the International Federation of Gynecology and Obstetrics stage (stage III-IV VS. I-II; HR= 10.054 p<0.001), residual tumor (yes VS. no for the first surgery; HR=5.014 p=0.001), histological features (endodermal sinus tumor combined with embryonal carcinoma VS. endodermal sinus tumor; HR=4.130 p=0.018), and use of platinum-based chemotherapy (courses≥3 VS. courses<3; HR= 0.188 p=0.004) were independent factors influencing recurrence; age, childbearing history, tumor site, tumor size, and serum α-fetoprotein level before initial management did not affect recurrence. In multivariate analysis, only stage was an independent risk factor for progression-free survival（stage III-IV VS. I-II; HR=6.923 p=0.019）. Conclusions: Stage is a prognostic factor for recurrence of pelvic endodermal sinus tumor. The first surgery should remove the tumor as completely as possible, and initial treatment should require a sufficient dose and full course of platinum-based chemotherapy, which may reduce the recurrence rate. Patients with endodermal sinus tumor and embryonal carcinoma may have increased susceptibility of recurrence.

Download Full-text

Diagnostic and prognostic value of EEG in prodromal dementia with Lewy bodies

Neurology ◽

10.1212/wnl.0000000000009977 ◽

2020 ◽

Vol 95 (6) ◽

pp. e662-e670 ◽

Cited By ~ 1

Author(s):

Jessica Joanne van der Zande ◽

Alida A. Gouw ◽

Inger van Steenoven ◽

Marleen van de Beek ◽

Philip Scheltens ◽

...

Keyword(s):

Prognostic Value ◽

Dementia With Lewy Bodies ◽

Lewy Bodies ◽

Peak Frequency ◽

Class Iii ◽

Time To Progression ◽

Prodromal Phase ◽

Eeg Abnormalities ◽

Diagnostic And Prognostic Value

ObjectiveEarly biomarkers for dementia with Lewy bodies (DLB) are lacking. To determine whether EEG differentiates the prodromal phase of DLB from other causes of mild cognitive impairment (MCI) and whether EEG is predictive for time to conversion from MCI to DLB, we compared EEGs and clinical follow-up of patients with MCI due to DLB with those of patients with MCI due to Alzheimer disease (MCI-AD).MethodsWe compared 37 patients with MCI who developed DLB during follow-up or had an abnormal 123I-PF-CIT SPECT scan (MCI-DLB) with 67 age-matched patients with MCI-AD. EEGs were assessed visually with a score of increasing abnormality (range 1–5). We performed fast Fourier transform to analyze the power spectrum. With survival analyses, EEG characteristics were related to time to progression to dementia.ResultsThe visual EEG score was higher in MCI-DLB (score >2 in 60%) compared to MCI-AD (score >2 in 8%, p < 0.001). We found frontal intermittent delta activity in 22% of MCI-DLB, not in MCI-AD. Patients with MCI-DLB had a lower peak frequency (7.5 [6.0–9.9] Hz vs 8.8 [6.8–10.2] in MCI-AD, p < 0.001) and more slow-wave activity. Several individual EEG measures showed good performance to discriminate MCI-DLB from MCI-AD (areas under the curve up to 0.94). In MCI-DLB, high visual EEG score, diffuse abnormalities, and low α2 power were related to time to progression to dementia (hazard ratios 4.1, 9.9, 5.1, respectively).ConclusionsProfound EEG abnormalities are already present in the prodromal stage of DLB and have diagnostic and prognostic value.Classification of evidenceThis study provides Class III evidence that EEG abnormalities are more common in MCI-DLB than MCI-AD.

Download Full-text