Age-dependent change in attention paid to vocal exchange rules in Japanese macaques

DBA/2J mouse has been used as a model for spontaneous secondary glaucoma. Here, we investigated changes in expression of NMDA receptor (NMDAR) subunits and Cdk5/p35/NMDAR signaling in retinas of DBA/2J mice using Western blot technique. The protein levels of NR1 and NR2A subunits in retinas of DBA/2J mice at all ages (6–12 months) were not different from those in age-matched C57BL/6 mice. In contrast, the protein levels of NR2B subunits, in addition to age-dependent change, significantly increased with elevated intraocular pressure (IOP) in DBA/2J mice at 6 and 9 months as compared with age-matched controls. Moreover, expression of Cdk5, p35 and ratio of p-NR2AS1232/NR2A progressively increased with time in both strains, suggestive of activated Cdk5/p35 signaling pathway. However, the changes in these proteins were in the same levels in both strain mice, except a significant increase of p35 proteins at 6 months in DBA/2J mice. Meanwhile, the protein levels of Brn-3a, a retinal ganglion cell (RGC) maker, remarkably decreased at 9–12 months in DBA/2J mice, which was in parallel with the changes of NR2B expression. Our results suggest that elevated IOP-induced increase in expression of NR2B subunits of NMDARs may be involved in RGC degeneration of DBA/2J mice.

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Age-dependent change in sensitivity of oestrogen-induced uterine cell proliferation of mice, estimated by incorporation of [125I]iododeoxyuridine

Journal of Steroid Biochemistry ◽

10.1016/0022-4731(85)90064-0 ◽

1985 ◽

Vol 23 (6) ◽

pp. 1037-1041 ◽

Cited By ~ 3

Author(s):

N. Terada ◽

T. Yamane ◽

Y. Ogasawara ◽

K. Matsumoto ◽

Y. Kitamura

Keyword(s):

Cell Proliferation ◽

Dependent Change ◽

Age Dependent

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Age-Dependent Change in a Soluble Factor Responsible for Th-2 Type of Help in the Indirect Plaque-Forming Antibody Response

Gerontology ◽

10.1159/000213094 ◽

1983 ◽

Vol 29 (1) ◽

pp. 49-63 ◽

Cited By ~ 4

Author(s):

T. Matsuzawa ◽

B. Cinader

Keyword(s):

Antibody Response ◽

Soluble Factor ◽

Dependent Change ◽

Age Dependent

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Age-Dependent Replication of Respiratory Syncytial Virus in the Cotton Rat

Experimental Biology and Medicine ◽

10.1177/153537020222700912 ◽

2002 ◽

Vol 227 (9) ◽

pp. 799-802 ◽

Cited By ~ 23

Author(s):

Spencer J. Curtis ◽

Martin G. Ottolini ◽

David D. Porter ◽

Gregory A. Prince

Keyword(s):

Respiratory Syncytial Virus ◽

Age Groups ◽

Fold Increase ◽

The Elderly ◽

Geriatric Population ◽

Cotton Rat ◽

Dependent Change ◽

Age Dependent ◽

Syncytial Virus ◽

Viral Titers

Despite the documented disease burden of respiratory syncytial virus (RSV) in the elderly, little is known about the underlying risk factors or pathogenesis of RSV in a geriatric population. This report describes an age-dependent change of RSV clearance in the lung and nose of the cotton rat. Six days postinfection with RSV, lung and nose viral titers were significantly higher in all older age groups as compared with 4- to 6-week old cotton rats (P < 0.05). When comparing the 4- to 6-week old animals to the 15- to 16-month old animals 6 days postinfection, there was over an 800- and 100-fold increase in lung and nose viral titers, respectively. The cotton rat may prove to be a useful model in eliciting mechanisms of severe RSV disease in the elderly.

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