scholarly journals Aldosterone receptor antagonists

2020 ◽  
Author(s):  
Michel Azizi
Keyword(s):  
Receptor Antagonists ◽  
Aldosterone Receptor

scholarly journals Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension: A Retrospective Analysis

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Pieter M. Jansen ◽  
Koen Verdonk ◽  
Ben P. Imholz ◽  
A. H. Jan Danser ◽  
Anton H. van den Meiracker
Keyword(s):  
Blood Pressure ◽  
Multivariate Analysis ◽  
Essential Hypertension ◽  
Primary Aldosteronism ◽  
Treatment Duration ◽  
Uncontrolled Hypertension ◽  
Receptor Antagonists ◽  
Aldosterone Receptor

Background. The long-term efficacy of aldosterone-receptor antagonists (ARAs) as add-on treatment in uncontrolled hypertension has not yet been reported.Methods. Data from 123 patients (21 with primary aldosteronism, 102 with essential hypertension) with difficult-to-treat hypertension who received an ARA between May 2005 and September 2009 were analyzed retrospectively for their blood pressure (BP) and biochemical response at first followup after start with ARA and the last follow-up available.Results. Systolic BP decreased by22±20and diastolic BP by9.4±12 mmHg after a median treatment duration of 25 months. In patients that received treatment >5 years, SBP was33±20and DBP was 16 ± 13 mmHg lower than at baseline. Multivariate analysis revealed that baseline BP and follow-up duration were positively correlated with BP response.Conclusion. Add-on ARA treatment in difficult-to-treat hypertension results in a profound and sustained BP reduction.

scholarly journals Aldosterone Receptor Antagonists in the Medical Management of Chronic Heart Failure

2005 ◽  
Vol 80 (12) ◽  
pp. 1623-1630 ◽  
Author(s):  
W. H. Wilson Tang ◽  
Anoop C. Parameswaran ◽  
Anjli P. Maroo ◽  
Gary S. Francis
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Medical Management ◽  
Receptor Antagonists ◽  
Aldosterone Receptor

scholarly journals Aldosterone Receptor Antagonists

Circulation ◽  
2010 ◽  
Vol 121 (7) ◽  
pp. 934-939 ◽  
Author(s):  
Bradley A. Maron ◽  
Jane A. Leopold
Keyword(s):  
Receptor Antagonists ◽  
Aldosterone Receptor

Roles of Aldosterone Receptor Antagonists in Heart Failure, Hypertension, and Chronic Kidney Disease

2016 ◽  
Vol 12 (3) ◽  
pp. 201-206 ◽  
Author(s):  
Amy Wang ◽  
Roa Elshehadeh ◽  
Di Rao ◽  
Elaine Yap ◽  
Alice Lee ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Receptor Antagonists ◽  
Aldosterone Receptor
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