scholarly journals 50P Early breast cancer in women aged 35 years or younger: A French population-based case control-matched analysis

2021 ◽  
Vol 32 ◽  
pp. S42
Author(s):  
O. Dufour ◽  
G. Houvenaeghel ◽  
J-M. Classe ◽  
M. Cohen ◽  
C. Faure ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Population Based ◽  
Case Control ◽  
French Population

Reproductive Factors and Risk of Breast Cancer by Tumour Subtypes Among Ghanaian Women: A Population-Based Case-Control Study

2019 ◽  
Author(s):  
Jonine Figueroa ◽  
Brittny C. Davis Lynn ◽  
Lawrence Edusei ◽  
Nicholas Titiloye ◽  
Ernest Adjei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Reproductive Factors ◽  
Population Based ◽  
Case Control ◽  
Ghanaian Women ◽  
Control Study

scholarly journals Population-Based Estimates of the Age-Specific Cumulative Risk of Breast Cancer for Pathogenic Variants in CHEK2: Findings from the Australian Breast Cancer Family Registry

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1378
Author(s):  
Tú Nguyen-Dumont ◽  
James G. Dowty ◽  
Jason A. Steen ◽  
Anne-Laure Renault ◽  
Fleur Hammet ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cumulative Risk ◽  
Population Based ◽  
Case Control ◽  
Cancer Information ◽  
Case Control Studies ◽  
Breast Cancer Family ◽  
Pathogenic Variants ◽  
Increased Risk ◽  
Control Family

Case-control studies of breast cancer have consistently shown that pathogenic variants in CHEK2 are associated with about a 3-fold increased risk of breast cancer. Information about the recurrent protein-truncating variant CHEK2 c.1100delC dominates this estimate. There have been no formal estimates of age-specific cumulative risk of breast cancer for all CHEK2 pathogenic (including likely pathogenic) variants combined. We conducted a population-based case-control-family study of pathogenic CHEK2 variants (26 families, 1071 relatives) and estimated the age-specific cumulative risk of breast cancer using segregation analysis. The estimated hazard ratio for carriers of pathogenic CHEK2 variants (combined) was 4.9 (95% CI 2.5–9.5) relative to non-carriers. The HR for carriers of the CHEK2 c.1100delC variant was estimated to be 3.5 (95% CI 1.02–11.6) and the HR for carriers of all other CHEK2 variants combined was estimated to be 5.7 (95% CI 2.5–12.9). The age-specific cumulative risk of breast cancer was estimated to be 18% (95% CI 11–30%) and 33% (95% CI 21–48%) to age 60 and 80 years, respectively. These findings provide important information for the clinical management of breast cancer risk for women carrying pathogenic variants in CHEK2.

scholarly journals PREDICT Plus: a population-based validation of a prognostic model for early breast cancer that includes HER2

The Breast ◽  
2012 ◽  
Vol 21 (2) ◽  
pp. 151 ◽  
Author(s):  
G.C. Wishart ◽  
C.D. Bajdik ◽  
E. Dicks ◽  
E. Provenzano ◽  
P.D.P. Pharoah
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Prognostic Model ◽  
Population Based

MnSOD polymorphism and breast cancer in a population-based case–control study

2003 ◽  
Vol 199 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Kathleen M Egan ◽  
Patricia A Thompson ◽  
Linda Titus-Ernstoff ◽  
Jason H Moore ◽  
Christine B Ambrosone
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Mnsod Polymorphism ◽  
Control Study
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