Potential antioxidant properties and hepatoprotective effects of  Juniperus phoenicea  berries against CCl 4  induced hepatic damage in rats

The research was aimed at evaluating the antiglycation, antioxidant, and hepatoprotective properties of methanolic extract of Anethum graveolens (dill). The antioxidant properties, photochemical characteristics, and antiglycation effects of dill extract were measured. Carbon tetrachloride-induced hepatotoxic rats were used to show the hepatoprotective activity of dill leaves. Different concentration of dill extract (0.032, 0.065, 0.125, 0.25, 0.5, and 1 mg/mL) showed potential antioxidant ability. The extract of dill leaves significantly reduced AGEs formation and also fructosamine and protein carbonyl levels in rats’ liver. Thiol groups’ oxidation, amyloid cross-β, and protein fragmentation (P<0.001) significantly reduced in treated rats. Liver damage markers significantly reduced in dill-treated animals (P<0.05). Dill with potential antioxidant, antiglycation, and hepatoprotective effects can be suggested for treatment of diabetes complications.

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Radical-Scavenging Activity and Ferric Reducing Ability ofJuniperus thurifera(L.),J. oxycedrus(L.),J. phoenicea(L.) andTetraclinis articulata(L.)

Advances in Pharmacological Sciences ◽

10.1155/2016/6392656 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6 ◽

Cited By ~ 13

Author(s):

Meryem El Jemli ◽

Rabie Kamal ◽

Ilias Marmouzi ◽

Asmae Zerrouki ◽

Yahia Cherrah ◽

...

Keyword(s):

Antioxidant Activities ◽

Antioxidant Properties ◽

Radical Scavenging ◽

Trolox Equivalent Antioxidant Capacity ◽

Total Phenolic ◽

Juniperus Thurifera ◽

Juniperus Oxycedrus ◽

Phenolic Contents ◽

Tetraclinis Articulata ◽

Juniperus Phoenicea

Objective. The aim of this work is to study and compare the antioxidant properties and phenolic contents of aqueous leaf extracts ofJuniperus thurifera,Juniperus oxycedrus,Juniperus Phoenicea,andTetraclinis articulatafrom Morocco.Methods. Antioxidant activities of the extracts were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical-scavenging ability, Trolox equivalent antioxidant capacity (TEAC), and ferric reducing antioxidant power (FRAP) assays. Also the total phenolic and flavonoids contents of the extracts were determined spectrophotometrically.Results. All the extracts showed interesting antioxidant activities compared to the standard antioxidants (butylated hydroxytoluene (BHT), quercetin, and Trolox). The aqueous extract ofJuniperus oxycedrusshowed the highest antioxidant activity as measured by DPPH, TEAC, and FRAP assays with IC50values of17.91±0.37 μg/mL,19.80±0.55 μg/mL, and24.23±0.07 μg/mL, respectively. The strong correlation observed between antioxidant capacities and their total phenolic contents indicated that phenolic compounds were a major contributor to antioxidant properties of these plants extracts.Conclusion. These results suggest that the aqueous extracts ofJuniperus thurifera,Juniperus oxycedrus,Juniperus phoenicea,andTetraclinis articulatacan constitute a promising new source of natural compounds with antioxidants ability.

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