New insights into the role of cytochrome P450 reductase (POR) in microsomal redox biology

Todd D. Porter

doi:10.1016/j.apsb.2012.02.002

New insights into the role of cytochrome P450 reductase (POR) in microsomal redox biology

Acta Pharmaceutica Sinica B ◽

10.1016/j.apsb.2012.02.002 ◽

2012 ◽

Vol 2 (2) ◽

pp. 102-106 ◽

Cited By ~ 11

Author(s):

Todd D. Porter

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 Reductase ◽

Redox Biology ◽

P450 Reductase

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Probing the role of lysines and arginines in the catalytic function of cytochrome P450d by site-directed mutagenesis. Interaction with NADPH-cytochrome P450 reductase

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)67801-4 ◽

1991 ◽

Vol 266 (6) ◽

pp. 3372-3375

Author(s):

T Shimizu ◽

T Tateishi ◽

M Hatano ◽

Y Fujii-Kuriyama

Keyword(s):

Cytochrome P450 ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Catalytic Function ◽

Nadph Cytochrome P450 Reductase

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Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase. Implications for increasing the activity against sensitive and multidrug-resistant leukaemia HL60 cells

Anti-Cancer Drugs ◽

10.1097/cad.0b013e32834fcf4f ◽

2012 ◽

Vol 23 (4) ◽

pp. 393-405 ◽

Cited By ~ 5

Author(s):

Dorota Kostrzewa-Nowak ◽

Bohdan Bieg ◽

Mark J.I. Paine ◽

C. Roland Wolf ◽

Jolanta Tarasiuk

Keyword(s):

Cytochrome P450 ◽

Multidrug Resistant ◽

Structural Factors ◽

Cytochrome P450 Reductase ◽

Hl60 Cells ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Anthraquinone Derivatives ◽

Nadph Cytochrome P450 Reductase

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Role of the prosthetic groups of NADPH-cytochrome P450 reductase in 3-hydroxyanthranilamide-catalyzed, NADPH-dependent superoxide anion production

Redox Report ◽

10.1080/13510002.1996.11747070 ◽

1996 ◽

Vol 2 (5) ◽

pp. 339-344

Author(s):

Y. Ohta ◽

R. Shinohara ◽

I. Ishiguro

Keyword(s):

Cytochrome P450 ◽

Superoxide Anion ◽

Cytochrome P450 Reductase ◽

Superoxide Anion Production ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Anion Production ◽

Nadph Cytochrome P450 Reductase ◽

Prosthetic Groups

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Conformational Dynamics and the Energetics of Protein−Ligand Interactions: Role of Interdomain Loop in Human Cytochrome P450 Reductase†

Biochemistry ◽

10.1021/bi700596s ◽

2007 ◽

Vol 46 (28) ◽

pp. 8244-8255 ◽

Cited By ~ 23

Author(s):

Alex Grunau ◽

Kalotina Geraki ◽

J. Günter Grossmann ◽

Aldo Gutierrez

Keyword(s):

Cytochrome P450 ◽

Conformational Dynamics ◽

Cytochrome P450 Reductase ◽

P450 Reductase ◽

Protein Ligand Interactions ◽

Human Cytochrome ◽

Ligand Interactions

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Determination of the Role of Target Tissue Metabolism in Lung Carcinogenesis Using Conditional Cytochrome P450 Reductase-Null Mice

Cancer Research ◽

10.1158/0008-5472.can-07-1006 ◽

2007 ◽

Vol 67 (16) ◽

pp. 7825-7832 ◽

Cited By ~ 64

Author(s):

Yan Weng ◽

Cheng Fang ◽

Robert J. Turesky ◽

Melissa Behr ◽

Laurence S. Kaminsky ◽

...

Keyword(s):

Cytochrome P450 ◽

Target Tissue ◽

Cytochrome P450 Reductase ◽

Lung Carcinogenesis ◽

Tissue Metabolism ◽

P450 Reductase

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Effector role of cytochrome P450 reductase for androstenedione binding to human aromatase

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2020.07.163 ◽

2020 ◽

Vol 164 ◽

pp. 510-517 ◽

Cited By ~ 2

Author(s):

Chao Zhang ◽

Gianluca Catucci ◽

Giovanna Di Nardo ◽

Gianfranco Gilardi

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 Reductase ◽

P450 Reductase ◽

Human Aromatase

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Role of LYS271 and LYS279 Residues in the Interaction of Cytochrome P4501A1 with NADPH–Cytochrome P450 Reductase

Archives of Biochemistry and Biophysics ◽

10.1006/abbi.2000.2174 ◽

2001 ◽

Vol 385 (2) ◽

pp. 290-300 ◽

Cited By ~ 9

Author(s):

Tomas Cvrk ◽

Henry W. Strobel

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 Reductase ◽

Cytochrome P4501a1 ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Nadph Cytochrome P450 Reductase

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Conditional Deletion of Cytochrome P450 Reductase in Osteoprogenitor Cells Affects Long Bone and Skull Development in Mice Recapitulating Antley-Bixler Syndrome: Role of a Redox Enzyme in Development

PLoS ONE ◽

10.1371/journal.pone.0075638 ◽

2013 ◽

Vol 8 (9) ◽

pp. e75638 ◽

Cited By ~ 7

Author(s):

Satya P. Panda ◽

Anyonya R. Guntur ◽

Srikanth R. Polusani ◽

Roberto J. Fajardo ◽

Peter T. Gakunga ◽

...

Keyword(s):

Cytochrome P450 ◽

Long Bone ◽

Cytochrome P450 Reductase ◽

Redox Enzyme ◽

Osteoprogenitor Cells ◽

Skull Development ◽

P450 Reductase ◽

Conditional Deletion

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Electron Transfer in Flavocytochrome P450 BM3: Kinetics of Flavin Reduction and Oxidation, the Role of Cysteine 999, and Relationships with Mammalian Cytochrome P450 Reductase†

Biochemistry ◽

10.1021/bi034562h ◽

2003 ◽

Vol 42 (36) ◽

pp. 10809-10821 ◽

Cited By ~ 35

Author(s):

Olivier Roitel ◽

Nigel S. Scrutton ◽

Andrew W. Munro

Keyword(s):

Electron Transfer ◽

Cytochrome P450 ◽

Cytochrome P450 Reductase ◽

P450 Bm3 ◽

P450 Reductase ◽

Reduction And Oxidation ◽

Kinetics Of

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Role of human cytochrome P450 (CYP) in the metabolic activation of N-alkylnitrosamines: application of genetically engineered Salmonella typhimurium YG7108 expressing each form of CYP together with human NADPH-cytochrome P450 reductase

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ◽

10.1016/s0027-5107(01)00223-8 ◽

2001 ◽

Vol 483 (1-2) ◽

pp. 35-41 ◽

Cited By ~ 40

Author(s):

Ken-ichi Fujita ◽

Tetsuya Kamataki

Keyword(s):

Cytochrome P450 ◽

Salmonella Typhimurium ◽

Metabolic Activation ◽

Genetically Engineered ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Human Cytochrome ◽

Nadph Cytochrome P450 Reductase

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