scholarly journals The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery

2021 ◽  
Author(s):  
Jingyi Li ◽  
Yaqi Zhang ◽  
Miaorong Yu ◽  
Aohua Wang ◽  
Yu Qiu ◽  
...  
Keyword(s):  
Insulin Delivery ◽  
Oral Insulin ◽  
Folate Transporters

Microparticles based on alginate/chitosan/casein three‐dimensional system for oral insulin delivery

2021 ◽  
Author(s):  
Zhenyu Xu ◽  
Long Chen ◽  
Xiaoya Duan ◽  
Xueming Li ◽  
Hao Ren
Keyword(s):  
Three Dimensional ◽  
Insulin Delivery ◽  
Dimensional System ◽  
Oral Insulin ◽  
Three Dimensional System

scholarly journals In vivo oral insulin delivery via covalent organic frameworks

2021 ◽  
Author(s):  
Farah Benyettou ◽  
Nawel Kaddour ◽  
Thirumurugan Prakasam ◽  
Gobinda Das ◽  
Sudhir Kumar Sharma ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Insulin Delivery ◽  
Oral Insulin ◽  
Covalent Organic Frameworks ◽  
Covalent Organic Framework ◽  
Organic Framework

We report the successful use of a gastro-resistant covalent organic framework for in vivo oral delivery of insulin.

Prerequisite Characteristics of Nanocarriers Favoring Oral Insulin Delivery: Nanogels as an Opportunity

2014 ◽  
Vol 64 (3) ◽  
pp. 155-167 ◽  
Author(s):  
Jahanzeb Mudassir ◽  
Yusrida Darwis ◽  
Peh Kok Khiang
Keyword(s):  
Insulin Delivery ◽  
Oral Insulin

Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery

Biomaterials ◽  
2009 ◽  
Vol 30 (29) ◽  
pp. 5691-5700 ◽  
Author(s):  
Lichen Yin ◽  
Jieying Ding ◽  
Chunbai He ◽  
Liming Cui ◽  
Cui Tang ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Insulin Delivery ◽  
Oral Insulin ◽  
Drug Permeability ◽  
Trimethyl Chitosan

Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous composites

2013 ◽  
Vol 7 (1) ◽  
pp. 9-19 ◽  
Author(s):  
Huining He ◽  
Junxiao Ye ◽  
Jianyong Sheng ◽  
Jianxin Wang ◽  
Yongzhuo Huang ◽  
...  
Keyword(s):  
Insulin Delivery ◽  
Cell Penetrating Peptide ◽  
Oral Insulin ◽  
Cell Penetrating

Strategies to improve insulin delivery through oral route: A review

2021 ◽  
Vol 18 ◽  
Author(s):  
Rohini Bhattacharya ◽  
Asha P. Johnson ◽  
Shailesh T. ◽  
Mohamed Rahamathulla ◽  
Gangadharappa H. V.
Keyword(s):  
Diabetes Mellitus ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Micelles ◽  
Insulin Delivery ◽  
Peptide Hormone ◽  
Diabetes Mellitus Type 1 ◽  
Delivery Systems ◽  
Oral Insulin ◽  
Subcutaneous Route

: Diabetes mellitus is found to be among the most suffered and lethal diseases for mankind. Diabetes mellitus type-1 is caused by the demolition of pancreatic islets responsible for the secretion of insulin. Insulin is the peptide hormone (anabolic] that regulates the metabolism of carbohydrates, fats, and proteins. Upon the breakdown of the natural process of metabolism, the condition leads to hyperglycemia (increased blood glucose levels]. Hyperglycemia demands outsourcing of insulin. The subcutaneous route was found to be the most stable route of insulin administration but faces patient compliance problems. Oral Insulin delivery systems are the patient-centered and innovative novel drug delivery system, eliminating the pain caused by the subcutaneous route of administration. Insulin comes in contact across various barriers in the gastrointestinal tract, which has been discussed in detail in this review. The review describes about the different bioengineered formulations, including microcarriers, nanocarriers, Self-Microemulsifying drug delivery systems (SMEDDs), Self-Nanoemulsifying drug delivery systems (SNEDDs), polymeric micelles, cochleates, etc. Surface modification of the carriers is also possible by developing ligand anchored bioconjugates. A study on evaluation has shown that the carrier systems facilitate drug encapsulation without tampering the properties of insulin. Carrier-mediated transport by the use of natural, semi-synthetic, and synthetic polymers have shown efficient results in drug delivery by protecting insulin from harmful environment. This makes the formulation readily acceptable for a variety of populations. The present review focuses on the properties, barriers present in the GI tract, overcome the barriers, strategies to formulate oral insulin formulation by enhancing the stability and bioavailability of insulin.

Dual-modified nanoparticles overcome sequential absorption barriers for oral insulin delivery

2021 ◽  
Author(s):  
Ziyue Xi ◽  
Ejaj Ahmad ◽  
Wei Zhang ◽  
Jingyi Li ◽  
Aohua Wang ◽  
...  
Keyword(s):  
Insulin Delivery ◽  
Oral Insulin ◽  
Sequential Absorption

Colloidal carrier integrating biomaterials for oral insulin delivery: Influence of component formulation on physicochemical and biological parameters

2009 ◽  
Vol 5 (7) ◽  
pp. 2475-2484 ◽  
Author(s):  
Camile B. Woitiski ◽  
Ronald J. Neufeld ◽  
António J. Ribeiro ◽  
Francisco Veiga
Keyword(s):  
Insulin Delivery ◽  
Oral Insulin ◽  
Biological Parameters ◽  
Colloidal Carrier

Advanced Nanostructures for Oral Insulin Delivery

2020 ◽  
pp. 187-212
Author(s):  
Chinnu Sabu ◽  
K. Pramod
Keyword(s):  
Insulin Delivery ◽  
Oral Insulin
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