Adsorption and swelling studies of 2-hydroxyethyl methacrylate- and N,N-dimethylacrylamide-based porous copolymers and their possible applications for QCM-sensors

Porous crosslinked copolymers of methacrylic acid with N-(2-hydroxypropyl) methacrylamide (HPMA) or (2-hydroxyethyl) methacrylate were prepared, and the relationship between their structure and the sorption of papain, bovine serumalbumin, chymotrypsinogen, pepsin, ovalbumin, insulin, novocain and oleandomycin were investigated. The presence of hydrophilic components in the gel structure makes possible additional interactions between sorbent and the compound sorbed. The occurrence of additional interactions (probably hydrogen bonds) is more pronounced with cation exchangers containing the (2-hydroxyethyl) methacrylate monomeric unit, which favourably affects the sorption of univalent organic cations but at the same time contributes to the denaturation of sorbed proteins. In contrast to univalent organic cations, cation exchangers containing the N-(2-hydroxypropyl) methacrylamide monomeric unit are more advantageous in the sorption of proteins, because due to the lower extent of additional interactions no irreversible denaturation of sorbed labile proteins takes place in this case.

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Radiation Induced Synthesis of 2‐Hydroxyethyl Methacrylate‐Co‐Vinylbenzyltrimethylammonium Chloride Binary Hydrogel System‐I: Equilibrium Swelling Studies

Journal of Macromolecular Science Part A ◽

10.1080/10601320500437250 ◽

2006 ◽

Vol 43 (2) ◽

pp. 327-343 ◽

Cited By ~ 4

Author(s):

Narender Kumar Goel ◽

Virendra Kumar ◽

Yatendra Kumar Bhardwaj ◽

Sunil Sabharwal

Keyword(s):

Hydroxyethyl Methacrylate ◽

Equilibrium Swelling ◽

Radiation Induced ◽

Swelling Studies ◽

Hydrogel System

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Compression Modulus and Equilibrium Swelling Studies of Poly(2-Hydroxyethyl Methacrylate) Hydrogels Formed at Various Polymer Concentrations

Soft Materials ◽

10.1080/1539445x.2013.870913 ◽

2014 ◽

Vol 12 (2) ◽

pp. 237-246 ◽

Cited By ~ 2

Author(s):

Burcu Kizmaz ◽

Nermin Orakdogen

Keyword(s):

Compression Modulus ◽

Hydroxyethyl Methacrylate ◽

Equilibrium Swelling ◽

Swelling Studies

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Hemocompatibility and swelling studies of poly(2-hydroxyethyl methacrylate-co-itaconic acid-co-poly(ethylene glycol) dimethacrylate) hydrogels

Hemijska industrija ◽

10.2298/hemind111005102d ◽

2011 ◽

Vol 65 (6) ◽

pp. 675-685 ◽

Cited By ~ 8

Author(s):

Sava Dobic ◽

Jovana Jovasevic ◽

Marija Vojisavljevic ◽

Simonida Tomic

Keyword(s):

Molecular Weight ◽

Ethylene Glycol ◽

Cell Viability ◽

Itaconic Acid ◽

Hydroxyethyl Methacrylate ◽

Poly Ethylene Glycol ◽

Swelling Properties ◽

Swelling Studies ◽

Poly Ethylene

In this study novel series of hydrogels, based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and poly(ethylene glycol) dimethacrylates (PEGDMA) (of varying molecular weight and concentration) were prepared by free radical crosslinking copolymerization. Preliminary hemocompatibility characterization of hydrogels obtained by hemolytic activity assay indicated good compatibility with blood. Preliminary biocompatibility characterization of P(HEMA/IA/PEGDMA) hydrogels, done by the cytotoxicity assays using the HeLa cell line revails that the cell viability of all samples was the range of 97?100%, with no significant decrease in cell viability with the change of PEGDMA molecular weight and concentration. Swelling studies were conducted for all P(HEMA/IA/PEGDMA) samples in a physiological pH and temperature range and network parameters were determined. Swelling studies showed pH sensitive behaviour, typical for anionic hydrogels, and temperature dependent swelling. The effects of concentration of PEGDMA component on hydrogel swelling properties depend on the PEGDMA molecular weight. The samples with 550PEGDMA show different swelling capacities when 550PEGDMA content is changed, whereas for P(HEMA/IA/875PEGDMA) samples there was practically no difference in equilibrium degree of swelling, qe ,with varying 875PEGDMA content, which trend is the same as in the case of qe versus pH dependences. It was concluded that P(HEMA/IA/PEGDMA) hydrogels show good potential to be used as biomedical materials.

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Porous copolymers of methacrylic acid with N-(2-hydroxypropyl) methacrylamide and (2-hydroxyethyl) methacrylate. Preparation, swelling and morphology

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19791925 ◽

1979 ◽

Vol 44 (6) ◽

pp. 1925-1930 ◽

Cited By ~ 1

Author(s):

Jiří Vacík ◽

Zdeněk Pelzbauer ◽

Nadezhda N. Kuznetsova ◽

Klavdia P. Papukova ◽

Larisa K. Shataeva ◽

...

Keyword(s):

Methacrylic Acid ◽

Crosslinking Agent ◽

Scanning Electron Microscopy Data ◽

Hydroxyethyl Methacrylate ◽

Electron Microscopy Data ◽

Bulk Weight ◽

Hydroxypropyl Methacrylamide ◽

Porous Copolymers ◽

Microscopy Data ◽

Porous Morphology

Porous copolymers of methacrylic acid with N-(2-hydroxypropyl) methacrylamide or (2-hydroxyethyl) methacrylate were prepared using 1,3,5-triacryloylhexahydrotriazine as the crosslinking agent. The copolymers were characterized by their swelling, bulk weight, and morphologically by scanning electron microscopy. Data thus obtained were used in the interpretation of the formation of different porous morphology, differing in the size and ordering of globules.

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