scholarly journals Developmental toxicity and thyroid hormone-disrupting effects of 2,4-dichloro-6-nitrophenol in Chinese rare minnow (Gobiocypris rarus)

2017 ◽  
Vol 185 ◽  
pp. 40-47 ◽  
Author(s):  
Rui Chen ◽  
Lilai Yuan ◽  
Jinmiao Zha ◽  
Zijian Wang
Keyword(s):  
Thyroid Hormone ◽  
Developmental Toxicity ◽  
Gobiocypris Rarus ◽  
Rare Minnow ◽  
Chinese Rare Minnow

scholarly journals Developmental Toxicity of Carbon Quantum Dots to the Embryos/Larvae of Rare Minnow (Gobiocypris rarus)

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Yuan-Yuan Xiao ◽  
Li Liu ◽  
Yao Chen ◽  
Yu-Lian Zeng ◽  
Ming-Zhi Liu ◽  
...  
Keyword(s):  
Developmental Stages ◽  
Developmental Toxicity ◽  
Carbon Quantum Dots ◽  
Spinal Curvature ◽  
Hatching Rate ◽  
Gobiocypris Rarus ◽  
Spontaneous Movements ◽  
Rare Minnow ◽  
Pericardial Edema ◽  
Cellular Dna

The toxic effects of CDs on rare minnow (Gobiocypris rarus) embryos at different developmental stages were investigated. The results showed that rare minnow embryos had decreased spontaneous movements, body length, increased heart rate, pericardial edema, yolk sac edema, tail/spinal curvature, various morphological malformations, and decreased hatching rate. Biochemical analysis showed the CDs exposure significantly inhibited the activity of Na+/K+-ATPase and Ca2+-ATPase and increased the MDA contents and the activity of SOD, CAT, and GPX. Further examination suggested that the CDs exposure induced serious embryonic cellular DNA damage. Moreover, the CDs exposure induced upregulation of development related genes (Wnt8aandMstn) along with the downregulation ofVezf1. Overall, the present study revealed that the CDs exposure has significant development toxicity on rare minnow embryos/larvae. Mechanistically, this toxicity might result from the pressure of induced oxidative stress coordinate with the dysregulated development related gene expression mediated by the CDs exposure.

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