Developmental Toxicity of Carbon Quantum Dots to the Embryos/Larvae of Rare Minnow (Gobiocypris rarus)

The toxic effects of CDs on rare minnow (Gobiocypris rarus) embryos at different developmental stages were investigated. The results showed that rare minnow embryos had decreased spontaneous movements, body length, increased heart rate, pericardial edema, yolk sac edema, tail/spinal curvature, various morphological malformations, and decreased hatching rate. Biochemical analysis showed the CDs exposure significantly inhibited the activity of Na+/K+-ATPase and Ca2+-ATPase and increased the MDA contents and the activity of SOD, CAT, and GPX. Further examination suggested that the CDs exposure induced serious embryonic cellular DNA damage. Moreover, the CDs exposure induced upregulation of development related genes (Wnt8aandMstn) along with the downregulation ofVezf1. Overall, the present study revealed that the CDs exposure has significant development toxicity on rare minnow embryos/larvae. Mechanistically, this toxicity might result from the pressure of induced oxidative stress coordinate with the dysregulated development related gene expression mediated by the CDs exposure.

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Developmental toxicity in rare minnow (Gobiocypris rarus) embryos exposed to Cu, Zn and Cd

Ecotoxicology and Environmental Safety ◽

10.1016/j.ecoenv.2014.03.018 ◽

2014 ◽

Vol 104 ◽

pp. 269-277 ◽

Cited By ~ 22

Author(s):

Bin Zhu ◽

Lei Liu ◽

Dong-Liang Li ◽

Fei Ling ◽

Gao-Xue Wang

Keyword(s):

Developmental Toxicity ◽

Gobiocypris Rarus ◽

Rare Minnow

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Developmental toxicity of 3,4-dichloroaniline on rare minnow (Gobiocypris rarus) embryos and larvae

Chemosphere ◽

10.1016/j.chemosphere.2012.09.021 ◽

2013 ◽

Vol 90 (3) ◽

pp. 1132-1139 ◽

Cited By ~ 35

Author(s):

Bin Zhu ◽

Tianqiang Liu ◽

Xuegang Hu ◽

Gaoxue Wang

Keyword(s):

Developmental Toxicity ◽

Gobiocypris Rarus ◽

Rare Minnow

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Developmental toxicity and thyroid hormone-disrupting effects of 2,4-dichloro-6-nitrophenol in Chinese rare minnow (Gobiocypris rarus)

Aquatic Toxicology ◽

10.1016/j.aquatox.2017.02.005 ◽

2017 ◽

Vol 185 ◽

pp. 40-47 ◽

Cited By ~ 14

Author(s):

Rui Chen ◽

Lilai Yuan ◽

Jinmiao Zha ◽

Zijian Wang

Keyword(s):

Thyroid Hormone ◽

Developmental Toxicity ◽

Gobiocypris Rarus ◽

Rare Minnow ◽

Chinese Rare Minnow

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InP/ZnS QDs exposure induces developmental toxicity in rare minnow ( Gobiocypris rarus ) embryos

Environmental Toxicology and Pharmacology ◽

10.1016/j.etap.2018.04.005 ◽

2018 ◽

Vol 60 ◽

pp. 28-36 ◽

Cited By ~ 4

Author(s):

Yao Chen ◽

Yang Yang ◽

Fang Ou ◽

Li Liu ◽

Xiao-hong Liu ◽

...

Keyword(s):

Developmental Toxicity ◽

Gobiocypris Rarus ◽

Rare Minnow

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Stepwise Embryonic Toxicity of Silver Nanoparticles onOryzias latipes

BioMed Research International ◽

10.1155/2013/494671 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 19

Author(s):

Jae-Gu Cho ◽

Kyung-Tae Kim ◽

Tae-Kwon Ryu ◽

Jae-woo Lee ◽

Ji-Eun Kim ◽

...

Keyword(s):

Heart Rate ◽

Silver Nanoparticles ◽

Embryonic Development ◽

Developmental Stages ◽

Developmental Toxicity ◽

Heart Beat ◽

Hatching Rate ◽

Dose Dependent Decrease ◽

Embryonic Toxicity ◽

Dose Dependent

The developmental toxicity of silver nanoparticles (AgNPs) was investigated following exposure ofOryzias latipes(medaka) embryos to 0.1−1 mg/L of homogeneously dispersed AgNPs for 14 days. During this period, developmental endpoints, including lethality, heart rate, and hatching rate, were evaluated by microscopy for different stages of medaka embryonic development. To compare toxic sensitivity, acute adult toxicity was assessed. There was no difference in acute lethal toxicity between embryo and adult medaka. Interestingly, we found that the increase in stepwise toxicity was dependent on the developmental stage of the embryo. Lethal embryonic toxicity increased from exposure days 1 to 3 and exposure days 5 to 8, whereas there was no change from exposure days 3 to 5. In addition, 7 d exposure to 0.8 mg/L AgNPs resulted in significant heart beat retardation in medaka embryos. AgNPs also caused a dose-dependent decrease in the hatching rate and body length of larvae. These results indicate that AgNP exposure causes severe developmental toxicity to medaka embryos and that toxicity levels are enhanced at certain developmental stages, which should be taken into consideration in assessments of metallic NPs toxicity to embryos.

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CuInS 2 /ZnS QD exposure induces developmental toxicity, oxidative stress and DNA damage in rare minnow ( Gobiocypris rarus ) embryos and larvae

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology ◽

10.1016/j.cbpc.2017.04.009 ◽

2017 ◽

Vol 198 ◽

pp. 19-27 ◽

Cited By ~ 6

Author(s):

Li Liu ◽

Yuan-Yuan Xiao ◽

Yan-Hong Ji ◽

Ming-Zhi Liu ◽

Yao Chen ◽

...

Keyword(s):

Oxidative Stress ◽

Dna Damage ◽

Developmental Toxicity ◽

Gobiocypris Rarus ◽

Rare Minnow

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Single and joint action toxicity of heavy metals on early developmental stages of Chinese rare minnow (Gobiocypris rarus)

Ecotoxicology and Environmental Safety ◽

10.1016/j.ecoenv.2011.07.033 ◽

2011 ◽

Vol 74 (8) ◽

pp. 2193-2202 ◽

Cited By ~ 40

Author(s):

Bin Zhu ◽

Zong-Fan Wu ◽

Jun Li ◽

Gao-Xue Wang

Keyword(s):

Heavy Metals ◽

Joint Action ◽

Developmental Stages ◽

Gobiocypris Rarus ◽

Rare Minnow ◽

Chinese Rare Minnow ◽

Early Developmental Stages ◽

Early Developmental

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Comparative Toxicity Assessment of Kratom Decoction, Mitragynine and Speciociliatine Versus Morphine on Zebrafish (Danio rerio) Embryos

Frontiers in Pharmacology ◽

10.3389/fphar.2021.714918 ◽

2021 ◽

Vol 12 ◽

Author(s):

Thenmoly Damodaran ◽

Nelson Jeng-Yeou Chear ◽

Vikneswaran Murugaiyah ◽

Mohd Nizam Mordi ◽

Surash Ramanathan

Keyword(s):

Therapeutic Potential ◽

Developmental Toxicity ◽

Toxicity Assessment ◽

Spinal Curvature ◽

Hatching Rate ◽

Morphological Development ◽

Zebrafish Embryos ◽

Dependent Manner ◽

Zebrafish Model ◽

Concentration Dependent Manner

Background: Kratom (Mitragyna speciosa Korth), a popular opioid-like plant holds its therapeutic potential in pain management and opioid dependence. However, there are growing concerns about the safety or potential toxicity risk of kratom after prolonged use.Aim of the study: The study aimed to assess the possible toxic effects of kratom decoction and its major alkaloids, mitragynine, and speciociliatine in comparison to morphine in an embryonic zebrafish model.Methods: The zebrafish embryos were exposed to kratom decoction (1,000–62.5 μg/ml), mitragynine, speciociliatine, and morphine (100–3.125 μg/ml) for 96 h post-fertilization (hpf). The toxicity parameters, namely mortality, hatching rate, heart rate, and morphological malformations were examined at 24, 48, 72, and 96 hpf, respectively.Results: Kratom decoction at a concentration range of ≥500 μg/ml caused 100% mortality of zebrafish embryos and decreased the hatching rate in a concentration-dependent manner. Meanwhile, mitragynine and speciociliatine exposure resulted in 100% mortality of zebrafish embryos at 100 μg/ml. Both alkaloids caused significant alterations in the morphological development of zebrafish embryos including hatching inhibition and spinal curvature (scoliosis) at the highest concentration. While exposure to morphine induced significant morphological malformations such as pericardial oedema, spinal curvature (lordosis), and yolk edema in zebrafish embryos.Conclusion: Our findings provide evidence for embryonic developmental toxicity of kratom decoction and its alkaloids both mitragynine and speciociliatine at the highest concentration, hence suggesting that kratom consumption may have potential teratogenicity risk during pregnancy and thereby warrants further investigations.

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