Changes in Clinical, Pulmonary Function, Quality of Life and Costs in a Cohort of Asthmatic Patients Followed for 10 Years

ABSTRACT CONTEXT AND OBJECTIVE: The combined effect of obesity and asthma may lead to significant impairment of quality of life (QOL). The aim here was to evaluate the prevalence of asthma among obese individuals, characterize the severity of impairment of quality of life and measure its relationship with pulmonary function. DESIGN AND SETTING: Observational cross-sectional study in public university hospital. METHODS: Morbidly obese individuals (body mass index > 40 kg/m2) seen in a bariatric surgery outpatient clinic and diagnosed with asthma, were included. Anthropometric data were collected, the Standardized Asthma Quality of Life Questionnaire (AQLQ(S)) was applied and spirometry was performed. The subjects were divided into two groups based on the median of the score in the questionnaire (worse < 4 and better > 4) and were compared regarding anthropometric data and pulmonary function. RESULTS: Among the 4791 individuals evaluated, 219 were asthmatic; the prevalence of asthma was 4.57%. Of these, 91 individuals were called to start multidisciplinary follow-up during the study period, of whom 82 answered the questionnaire. The median score in the AQLQ(S) was 3.96 points and, thus, the individuals were classified as having moderate impairment of their overall QOL. When divided according to better or worse QOL, there was a statistically difference in forced expiratory flow (FEF) 25-75%, with higher values in the better QOL group. CONCLUSION: The prevalence of asthma was 4.57% and QOL was impaired among the asthmatic obese individuals. The worst QOL domain related to environmental stimuli and the best QOL domain to limitations of the activities. Worse QOL was correlated with poorer values for FEF 25-75%.

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Reliability and validity of the asthma quality of life questionnaire—marks in a sample of adult asthmatic patients in the United States

Clinical Therapeutics ◽

10.1016/s0149-2918(97)80064-1 ◽

1997 ◽

Vol 19 (5) ◽

pp. 1116-1125 ◽

Cited By ~ 13

Author(s):

Gireesh V. Gupchup ◽

Alan P. Wolfgang ◽

Joseph Thomas

Keyword(s):

Quality Of Life ◽

United States ◽

Reliability And Validity ◽

The United States ◽

Life Questionnaire ◽

Quality Of Life Questionnaire ◽

Asthmatic Patients ◽

Adult Asthmatic

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A Study on Improvement of Pulmonary Function and Quality of Life in the Incentive Spirometer Breathing Exercise in the Elderly with Mild Cognitive Impairment

The Korean Health & Fundamental Medical Science Society ◽

10.37152/kmhs.2021.14.2.137 ◽

2021 ◽

Vol 14 (2) ◽

pp. 137-142

Author(s):

Gi-Do Kim

Keyword(s):

Quality Of Life ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Pulmonary Function ◽

The Elderly ◽

Breathing Exercise

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Health-related quality of life associates with clinical parameters in patients with NTM pulmonary disease

The International Journal of Tuberculosis and Lung Disease ◽

10.5588/ijtld.20.0790 ◽

2021 ◽

Vol 25 (4) ◽

pp. 299-304

Author(s):

K. Kawahara ◽

M. Tabusadani ◽

K. Yamane ◽

S. Takao ◽

Y. Kuroyama ◽

...

Keyword(s):

Quality Of Life ◽

Pulmonary Function ◽

Pulmonary Disease ◽

Clinical Parameters ◽

Health Related Quality ◽

Cross Sectional ◽

Related Quality ◽

Health Related ◽

Radiological Score

BACKGROUND: Previous studies have shown a reduction in health-related quality of life (HRQoL) in patients with non-tuberculous mycobacterial pulmonary disease (NTM-PD). However, the causes of this decline and the factors that contribute to it are unknown. This study was conducted to analyse the association between the St George´s Respiratory Questionnaire (SGRQ) and clinical parameters, including age, disease duration, body composition, pulmonary function, chest X-ray findings, blood data and physical function.METHODS: We performed a single-centre, cross-sectional, retrospective study of 101 patients with NTM-PD from December 2016 to October 2019. The relationship between the SGRQ scores and clinical parameters was evaluated.RESULTS: The median patient age was 67.0 years. Pulmonary function, radiological score, albumin levels, C-reactive protein levels and incremental shuttle walk test distance (ISWD) were significantly correlated with the total and component scores on the SGRQ. Multiple regression analysis showed that the SGRQ score was significantly associated with radiological score, pulmonary function and ISWD.CONCLUSION: This study was the first to assess the effect of clinical parameters on the SGRQ in patients with NTM-PD. HRQoL as determined using the SGRQ was associated with the radiological score, pulmonary function and ISWD in patients with NTM-PD.

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Fatigue is Highly Prevalent in Patients with Asthma and Contributes to the Burden of Disease

Journal of Clinical Medicine ◽

10.3390/jcm7120471 ◽

2018 ◽

Vol 7 (12) ◽

pp. 471 ◽

Cited By ~ 10

Author(s):

Maarten Van Herck ◽

Martijn Spruit ◽

Chris Burtin ◽

Remco Djamin ◽

Jeanine Antons ◽

...

Keyword(s):

Quality Of Life ◽

Asthma Control ◽

Global Strategy ◽

Airflow Limitation ◽

Stepwise Multiple Regression ◽

Life Questionnaire ◽

Exacerbation Rate ◽

Asthmatic Patients ◽

Severe Fatigue

The 2018 update of the Global Strategy for Asthma Management and Prevention does not mention fatigue-related symptoms. Nevertheless, patients with asthma frequently report tiredness, lack of energy, and daytime sleepiness. Quantitative research regarding the prevalence of fatigue in asthmatic patients is lacking. This retrospective cross-sectional study of outpatients with asthma upon referral to a chest physician assessed fatigue (Checklist Individual Strength-Fatigue (CIS-Fatigue)), lung function (spirometry), asthma control (Asthma Control Questionnaire (ACQ)), dyspnea (Medical Research Council (MRC) scale), exercise capacity (six-minute walk test (6MWT)), and asthma-related Quality-of-Life (QoL), Asthma Quality of Life Questionnaire (AQLQ) during a comprehensive health-status assessment. In total, 733 asthmatic patients were eligible and analyzed (47.4 ± 16.3 years, 41.1% male). Severe fatigue (CIS-Fatigue ≥ 36 points) was detected in 62.6% of patients. Fatigue was not related to airflow limitation (FEV1, ρ = −0.083); was related moderately to ACQ (ρ = 0.455), AQLQ (ρ = −0.554), and MRC (ρ = 0.435; all p-values < 0.001); and was related weakly to 6MWT (ρ = −0.243, p < 0.001). In stepwise multiple regression analysis, 28.9% of variance in fatigue was explained by ACQ (21.0%), MRC (6.5%), and age (1.4%). As for AQLQ, 42.2% of variance was explained by fatigue (29.8%), MRC (8.6%), exacerbation rate (2.6%), and age (1.2%). Severe fatigue is highly prevalent in asthmatic patients; it is an important determinant of disease-specific QoL and a crucial yet ignored patient-related outcome in patients with asthma.

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